Drug induced TdP risks classification assay using electro-mechanical models of human ventricle based on CiPA framework [0.03%]
基于CiPA框架的药物诱发TdP风险分类电机械模型试验
Aulia Khamas Heikhmakhtiar,Ali Ikhsanul Qauli,Yunendah Nur Fu&#x;adah et al.
Aulia Khamas Heikhmakhtiar et al.
Predicting drug-induced cardiac toxicity is critical for drug safety assays, especially when evaluating risks of inducing Torsade de Pointes (TdP). This study proposes an integrated electromechanical model of myocytes for TdP risk assessmen...
A decrease in Atp8a2 expression in Purkinje cells mediated acrylamide-induced cerebellar pathology in rats [0.03%]
阿特帕8A2蛋白在皮层棘细胞中表达降低介导丙烯酰胺致大鼠小脑病理损伤
Kai Yan,Wenhui Liu,Siqi Xu et al.
Kai Yan et al.
Atp8a2 is a type of phospholipid flippases, highly expressed in the cerebellum, functioning to maintain the stability and normal function of the cytomembrane by transporting phosphatidylserine into the cytoplasmic membrane. Atp8a2 mutations...
Sex-dependent neurotoxicity of environmental toxicants: a narrative review [0.03%]
环境毒物的性别特异性神经毒性：综述性文章
Yunkyung Eom,Jaebeom Cho,Ki-Woon Kang et al.
Yunkyung Eom et al.
Environmental pollutants, whether naturally occurring or manufactured for commercial use, are pervasive in modern ecosystems. Endocrine disruptors, particulate matter, and micro- and nanoplastics are especially concerning because of their u...
Artificial intelligence‑based quantitative analysis of hepatic fibrosis in carbon tetrachloride-induced mouse model of metabolic dysfunction-associated steatohepatitis [0.03%]
基于人工智能的四氯化碳致代谢功能障碍相关steatohepatitis小鼠模型肝纤维化定量分析
Jin-Hee Lee,Myung-Hwa Yang,Gyeongjin Han et al.
Jin-Hee Lee et al.
Liver fibrosis, a major histopathological indicator of chronic liver injury, is also a key feature of metabolic dysfunction-associated steatohepatitis. Its quantitative assessment in preclinical toxicology is frequently inconsistent and sub...
Rapid ecotoxicity and genotoxicity assessment using Macropodus ocellatus cells [0.03%]
基于Macropodus ocellatus细胞的快速毒性评价方法及遗传毒性效应研究
Minseon Kim,Ji Ho Park,Byeonghyeon So et al.
Minseon Kim et al.
Toxic substances can cause serious harm to aquatic organisms and humans who consume them. Rapid ecotoxicity assessment and genotoxicity assessment should be performed simultaneously to detect potential harm caused by toxic substances. In a ...
The future of toxicity testing: the emerging role of organ-on-a-chip platforms [0.03%]
毒性检测的未来：芯片器官平台的作用逐渐增强
Kumsal Kocadal,Dilek Battal,Sahan Saygi
Kumsal Kocadal
The 3Rs are guiding principles that must be followed when designing studies and conducting toxicity research. There is ongoing controversy regarding the use of animals in research. Moreover, the European Union outlawed animal experimentatio...
Phloroglucinol protects skin cells from particulate matter 2.5-induced oxidative stress and apoptosis [0.03%]
愈创草酚通过Nrf2抗氧化途径保护皮肤细胞免受PM2.5诱导的氧化应激和凋亡损伤
Pincha Devage Sameera Madushan Fernando,Kyoung Ah Kang,Mei Jing Piao et al.
Pincha Devage Sameera Madushan Fernando et al.
Particulate matter 2.5 (PM2.5) is an air pollutant that causes skin inflammation and aging. Phloroglucinol (PG) is a naturally occurring polyphenol with strong antioxidant potential that is widely used in pharmaceutical production. Informat...
Investigation of alternative cell models to BALB/c 3T3 for in vitro neutral red uptake phototoxicity test of pharmaceuticals: NIH 3T3 and HaCaT cells [0.03%]
用于药物的体外中性红摄取光毒性试验的BALB/C 3T3细胞替代模型（NIH 3T3和HaCaT细胞）的研究
Jee-Hyun Hwang,Jeong-Hyun Hong,Kyung-Min Lim
Jee-Hyun Hwang
Phototoxicity assessment is a critical component of preclinical safety assessment of pharmaceuticals with potential photosensitivity. 3T3 Neutral Red Uptake (NRU) Phototoxicity test, OECD Test Guideline 432, has been widely used as a refere...
Deficiency of the voltage‑gated proton channel Hv1 aggravates lung damage induced by exposure to carboxylated carbon black and carboxylated carbon black@lead [0.03%]
缺电压门控质子通道Hv1加重羧基碳黑及羧基碳黑@铅引起的肺损伤缺陷
Shangrong Zhang,Ji Chen,Jie Li et al.
Shangrong Zhang et al.
Black carbon has attracted significant attention because of its severe health hazards. Carbon black (CB), a commercially available standardized particulate material, is widely used as a surrogate model in toxicological studies. The voltage-...
Effect of high caffeine exposure on longitudinal bone growth during puberty in immature female rats [0.03%]
高咖啡因摄入对青春期前雌鼠青春期骨骼生长的影响
Jihyun Keum,Yuri Choi,Ki-Young Ryu et al.
Jihyun Keum et al.
Puberty is a critical period for skeletal growth. Although previous studies have demonstrated detrimental effects of caffeine on the skeletal system, most have used male rats to avoid the individual variability associated with rising estrog...