Validation of a B cell acute lymphoblastic leukemia xenograft rat model for integrated efficacy, pharmacokinetics and safety of CD19 CAR-T [0.03%]
用于评估CD19-CAR-T整合疗效、药代动力学及安全性的B淋巴细胞急性白血病异种移植大鼠模型的验证
Joo-Il Kim,Mi-Young Park,Euna Kwon et al.
Joo-Il Kim et al.
In preclinical studies of B cell acute lymphoblastic leukemia (B-ALL), mouse models have limitations related to their small body size, which restricts serial sampling required for integrated assessment of efficacy, safety, and pharmacokinet...
Cigarette smoke exposure worsens the severity of alcoholic liver disease by increasing CYP pathway signaling in mice [0.03%]
吸烟通过增加小鼠的细胞色素P450信号通路活性来加重酒精性肝病病理损害
Hyuneui Jeong,Jong-Won Kim,Daram Yang et al.
Hyuneui Jeong et al.
Cigarette smoke (CS) is a major risk factor for both acute and chronic diseases, predominantly impacting the lungs and cardiovascular system. Increasing evidence indicates that CS also has substantial but underappreciated effects on liver h...
Safety assessment of methylene bis-benzotriazolyl tetramethylbutylphenol, a UV filter in cosmetics [0.03%]
一种紫外线吸收剂甲基苯并三唑茋
Minhyuk Kim,Su Bin Kim,Jung Dae Lee et al.
Minhyuk Kim et al.
Methylene bis-benzotriazolyl tetramethylbutylphenol (MBBT) is a UV filter and UV absorber used in cosmetics. In this study, the acute toxicity, repeated dose toxicity, skin irritation, ocular irritation, skin sensitization, reproductive, an...
Exploring the molecular association between Di(2-ethylhexyl)phthalate and dilated cardiomyopathy based on interpretable machine learning and molecular docking [0.03%]
基于可解释机器学习和分子对接的Di(2-乙基己基)邻苯二甲酸与扩张型心肌病分子关联性研究
Xiao Xia,Lanshuo Hu,Shiyi Tao et al.
Xiao Xia et al.
This study aims to explore the molecular association between di(2-ethylhexyl)phthalate (DEHP) and dilated cardiomyopathy (DCM) through interpretable machine learning and molecular docking techniques. DCM transcriptome datasets (GSE120895, G...
Methotrexate-induced hepatotoxicity-mechanism, clinical cases and treatment approaches [0.03%]
甲氨蝶呤肝毒性-机制、临床病例和治疗策略
Anand Kumar Shah,Souvik Banerjee,Shareen Singh et al.
Anand Kumar Shah et al.
Methotrexate (MTX) is a class of antifolate chemotherapeutics and immunosuppressants that are effectively used in the treatment regimen of cancer and autoimmune diseases. In the current MASLD era, methotrexate-induced hepatotoxicity must be...
In silico cardiac safety assessment using a multi-biomarker approach based on an electrophysiological model of hiPSC-derived cardiomyocytes [0.03%]
基于hiPSC分化的心肌细胞电生理模型的多生物标志物方法的在体外心脏安全评估
Ari Kurniawan Saputra,Ali Ikhsanul Qauli,Aroli Marcellinus et al.
Ari Kurniawan Saputra et al.
Torsade de Pointes (TdP) is a potentially fatal ventricular arrhythmia associated with drug-induced disturbances of cardiac repolarization. Because QT interval prolongation alone provides limited mechanistic specificity, the Comprehensive i...
Esculetin alleviates IgA nephropathy in rats by improving intestinal mucosal function through the IL-17/NF-κB signaling [0.03%]
七叶亭素通过改善肠道黏膜屏障功能抑制IGA肾炎小鼠炎症反应
Fan Ye,Jian Liu
Fan Ye
Based on the "gut-kidney axis" theory, the disruption of the intestinal barrier function has been identified as a contributor to the occurrence and development of IgA nephropathy (IgAN). Esculetin, as a bioactive compound isolated from the ...
Inflammatory reprogramming of alveolar macrophages by the bacterial peptide iE-DAP via PEPT2 transport [0.03%]
细菌肽iE-DAP通过PEPT2转运重塑肺泡巨噬细胞的功能
Masashi Kawami,Yutaka Takeuchi,Kosuke Fuji et al.
Masashi Kawami et al.
Alveolar macrophages serve as key sentinels of pulmonary immunity, yet the mechanisms by which they recognize and respond to bacterial-derived peptides remain poorly understood. Here, we demonstrate for the first time that the peptide trans...
Punicalagin mitigates benzo[α]pyrene induced epithelial-mesenchymal transition and migration in triple‑negative breast cancer cells [0.03%]
蒲公英素通过抑制上皮间质转化和迁移减轻苯并[a]芘对三阴性乳腺癌细胞的致癌作用
Zeeshan Ahmad Bhutta,Cho-Won Kim,Kyung-Chul Choi
Zeeshan Ahmad Bhutta
Breast cancer is one of the most prevalent cancers among women, often attributed to genetic mutations, hormonal imbalances, and lifestyle factors. The compound benzo[α]pyrene (B[α]P) is commonly found in emissions and fumes from industria...
PK/PD interactions of antiarrhythmic drugs and oral anticoagulants in atrial fibrillation patients: clinical implications for stroke and dementia prevention [0.03%]
心房颤动患者抗心律失常药物和口服抗凝药的药代/药效学相互作用：预防卒中和痴呆的临床意义
Min Gyeong Oh,Byoungduck Park,Yu Chul Kim
Min Gyeong Oh
Atrial fibrillation (AF), the most prevalent arrhythmia affecting over 33 million individuals worldwide, markedly increases the risk of stroke and dementia. AF confers a nearly fivefold higher risk of stroke, accounting for up to one-third ...