Deficiency of the voltage‑gated proton channel Hv1 aggravates lung damage induced by exposure to carboxylated carbon black and carboxylated carbon black@lead [0.03%]
缺电压门控质子通道Hv1加重羧基碳黑及羧基碳黑@铅引起的肺损伤缺陷
Shangrong Zhang,Ji Chen,Jie Li et al.
Shangrong Zhang et al.
Black carbon has attracted significant attention because of its severe health hazards. Carbon black (CB), a commercially available standardized particulate material, is widely used as a surrogate model in toxicological studies. The voltage-...
Effect of high caffeine exposure on longitudinal bone growth during puberty in immature female rats [0.03%]
高咖啡因摄入对青春期前雌鼠青春期骨骼生长的影响
Jihyun Keum,Yuri Choi,Ki-Young Ryu et al.
Jihyun Keum et al.
Puberty is a critical period for skeletal growth. Although previous studies have demonstrated detrimental effects of caffeine on the skeletal system, most have used male rats to avoid the individual variability associated with rising estrog...
Integrated biomarker analysis and next-generation AI for precision diabetes prediction [0.03%]
整合生物标志物分析和下一代人工智能实现精准糖尿病预测
Hyun Sim,Hyung-Ho Ha,Hangun Kim
Hyun Sim
This study explored the integration of advanced deep learning with key pharmaceutical biomarkers to enhance early diabetes prediction. We developed a multimodal ensemble approach that leverages transformer architectures to capture complex d...
miR-143-3p mediates mercury chloride-induced neurotoxicity by targeting LMO4 and the Akt/GSK3β/mTOR pathway in vitro [0.03%]
mir-143-3p通过靶向lmo4和akt/gsk3β/mtor通路介导氯化汞诱导的神经毒性体外研究
Dile Wang,Yonggui Liao,Tao He
Dile Wang
Mercuric chloride (HgCl2), a common environmental neurotoxin, induces neuronal injury through incompletely characterized mechanisms. Recent findings suggest a regulatory role for microRNAs (miRNAs) in mercury-induced neurotoxicity, with miR...
β-Alanine alleviated non-alcoholic fatty liver disease via regulation of hepatic sulfur-amino acid metabolism in mice [0.03%]
β-丙氨酸通过调节小鼠肝脏中的硫氨基酸代谢缓解非酒精性脂肪肝病
Joohee Lee,Sou-Hyun Kim,Jiwon Hwang et al.
Joohee Lee et al.
β-Alanine is a non-essential β-amino acid used as a dietary supplement for improvement of exercise performance. The hepatic influence of β-alanine has been controversial in previous studies and its effects on nonalcoholic fatty liver dis...
Bisphenol AF induces mouse spermatogonia apoptosis via reactive oxygen species-mediated Beclin-1 cleavage [0.03%]
双酚AF通过活性氧介导的Beclin-1切割诱导小鼠精原细胞凋亡
Hyo Jin Gu,Gil Un Han,Seul Gi Kim et al.
Hyo Jin Gu et al.
Oxidative stress plays an essential role in homeostasis, cell signaling, and host defense mechanisms. However, excessive levels are harmful and cause DNA damage, lipid peroxidation, and mitochondrial dysfunction, ultimately causing cell dea...
Effect of aerosolized benzalkonium chloride exposure in in vitro cell models using air-liquid interface culture for inhalation toxicity screening [0.03%]
气溶胶化苯扎氯铵吸入暴露对体外空气-液体界面培养细胞模型的毒性效应筛查研究
Ji-Hyun Bang,Siu Lee,Nam-Ju Kim et al.
Ji-Hyun Bang et al.
Pesticides, biocides, and disinfectants used in veterinary medicine are frequently applied in spray form, necessitating inhalation toxicity testing. This study aimed to cultivate cells in an air-liquid interface (ALI) system for in vitro in...
Decabromodiphenyl ethane, a flame retardant, acts as a thyroid hormone receptor antagonist [0.03%]
十溴二苯乙烷这种阻燃剂能够充当甲状腺激素受体拮抗剂
Soocheol Choi,Hyunki Cho,Md Adnan Karim et al.
Soocheol Choi et al.
Flame retardants are integral components in numerous consumer and industrial products. Accumulating research has shown that retardants disrupt the endocrine system via the modulation of thyroid hormone receptors (THRs). To investigate the m...
Chandrashekara Vishwanath,Kumar Krishnachari,Gowrav Perdur Adiga et al.
Chandrashekara Vishwanath et al.
Semaglutide is an anti-obesity and anti-diabetic drug used in long-term weight management and for the treatment of type 2 diabetes. A toxicology study was conducted on a generic synthetic version of Semaglutide Injection (2 mg/3 mL) produce...
Is salsolinol a friend or foe? Revisiting its roles in neurotoxicity and cellular protection [0.03%]
萨尔ソ林是敌还是友？再访其神经毒性及细胞保护作用
Chan-Mi Park,Hye-Kyung Na
Chan-Mi Park
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, SAL) is a dopamine-derived tetrahydroisoquinoline, first identified in the urine of a Parkinson's disease patient treated with L-DOPA. SAL is generated endogenously via both...