PK/PD interactions of antiarrhythmic drugs and oral anticoagulants in atrial fibrillation patients: clinical implications for stroke and dementia prevention [0.03%]
心房颤动患者抗心律失常药物和口服抗凝药的药代/药效学相互作用：预防卒中和痴呆的临床意义
Min Gyeong Oh,Byoungduck Park,Yu Chul Kim
Min Gyeong Oh
Atrial fibrillation (AF), the most prevalent arrhythmia affecting over 33 million individuals worldwide, markedly increases the risk of stroke and dementia. AF confers a nearly fivefold higher risk of stroke, accounting for up to one-third ...
Methylmercury causes pain disorders by disrupting the neuronal function of spinal dorsal horn neurons in mice [0.03%]
甲基汞通过破坏小鼠脊髓背角神经元功能引起痛觉异常
Ryota Yamagata,Miyu Fujishima,Yuna Shoji et al.
Ryota Yamagata et al.
Methylmercury is a neurotoxic substance that is ubiquitously present in the environment and is known to cause a variety of neurological symptoms, including sensory impairment. Although methylmercury exposure causes conflicting symptoms of h...
The oncogenic signalosome: SQSTM1/p62 as a master integrator of signaling, metabolism, and autophagy in cancer [0.03%]
致癌信号体：SQSTM1 / p62作为癌症中信号传导，代谢和自噬的主要整合者
Eun-Ji Choi,Sang-Min Jeon
Eun-Ji Choi
Sequestosome 1 (SQSTM1/p62), long established as a selective autophagy receptor and ubiquitin-binding scaffold, is now recognized as an emerging regulatory hub that integrates signaling, metabolism, and stress adaptation in cancer. Beyond i...
In vitro metabolism and inhibitory effect of vonifimod on drug-metabolizing enzymes in human liver preparations [0.03%]
体外人工肝培养体系中vonifirmod的代谢及对药物代谢酶的抑制作用研究
Eun Jeong Kim,Min Seo Lee,Yang Hae Park et al.
Eun Jeong Kim et al.
Vonifimod is a novel sphingosine-1-phosphate receptor (S1PR) modulator with selectivity for S1PR1 and S1PR4 that is under development for the treatment of autoimmune disease. No reports on vonifimod metabolism exist except for the formation...
The bioaccumulation and carcinogenic potential of micro- and nanoplastics in humans [0.03%]
人体内微塑料和纳米塑料的生物累积及致癌潜力
Ghulam Nabi,Tariq Aziz,Lin Lin
Ghulam Nabi
The rising concentrations of anthropogenic microplastics (MPs; 1 µm to 5 mm) and nanoplastics (NPs; < 1 µm) pollution pose a global crisis, presenting a grave threat to the ecosystem and the health of living creatures within. Studies betw...
Polymer- and size-dependent toxicological behavior of environmentally relevant secondary microplastics: a comprehensive review [0.03%]
环境相关二次微塑料的毒理学行为的全面综述：基于聚合物和尺寸的影响
Sijoon Lee
Sijoon Lee
Microplastics (MPs) generated from commonly used consumer polymers are increasingly recognized as emerging contaminants of toxicological concern. Despite growing evidence, a consolidated understanding of how polymer identity and particle si...
Transferability and reproducibility of IMMUNOTOX-T assay, an in vitro method for evaluation of chemical-mediated immunotoxicity [0.03%]
IMMUNOTOX-T检测方法的可转移性和重现性研究：一种体外化学免疫毒理学评价方法
SoYeon Kim,Anju Maharjan,DaHee Son et al.
SoYeon Kim et al.
In vivo evaluation of the immunotoxicity of xenobiotics is mainly carried out in rodents. Recent trends following the 3R (reduction, refinement, replacement) principle have driven development of in vitro methods for screening immunotoxic ch...
The resveratrol-induced apoptosis and/or necroptosis of lung cancer cells is dependent on the activation status of PARP-1 and MLKL under oxidative stress [0.03%]
PARP-1和MLKL在氧化应激下介导的白杨素诱导肺癌细胞凋亡或坏死型程序性死亡的作用及机制研究
Gwan-Hwan Wi,Seon-Hee Oh
Gwan-Hwan Wi
While numerous studies have described the anticancer effects of resveratrol (RES), some aspects of its underlying molecular mechanisms remain to be elucidated. In this study, we investigated the molecular mechanisms by which RES attenuates ...
Disinfection's impact on the environment, molecular cross-resistance with antibiotics, and modern reduction approaches [0.03%]
消毒对环境的影响、与抗生素的分子交叉耐受性以及现代减少方法
Mohammed F Hamdi
Mohammed F Hamdi
Industrial disinfectant use has become concerning due to its antimicrobial resistance (AMR)- promoting properties, leading to antibiotic and disinfectant co-resistance. This research investigates the genetic processes by which disinfectants...
Drug induced TdP risks classification assay using electro-mechanical models of human ventricle based on CiPA framework [0.03%]
基于CiPA框架的药物诱发TdP风险分类电机械模型试验
Aulia Khamas Heikhmakhtiar,Ali Ikhsanul Qauli,Yunendah Nur Fu&#x;adah et al.
Aulia Khamas Heikhmakhtiar et al.
Predicting drug-induced cardiac toxicity is critical for drug safety assays, especially when evaluating risks of inducing Torsade de Pointes (TdP). This study proposes an integrated electromechanical model of myocytes for TdP risk assessmen...