Extracellular matrix protein 1 in cancer: multifaceted roles in tumor progression, prognosis, and therapeutic targeting [0.03%]
细胞外基质蛋白1在癌症中的作用：肿瘤进展、预后和治疗靶点的多面性
Jue Wang,Qionglian Huang,Hanjuan Ning et al.
Jue Wang et al.
Extracellular matrix protein 1 (ECM1) is a multifunctional glycosylated protein associated with the cell membrane. Increasing evidence indicates that aberrant ECM1 expression in cancer cells promotes tumor growth and metastasis by regulatin...
Dual inhibitors of P-glycoprotein and breast cancer resistance protein for overcoming the blood-brain barrier: in silico discovery and preclinical evaluation [0.03%]
用于克服血脑屏障的P-糖蛋白和乳腺癌耐药蛋白双抑制剂的计算机发现及临床前评估
Jiyeon Kang,Yukyeong Paik,Hwa Jeong Ryu et al.
Jiyeon Kang et al.
P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are typical ABC efflux transporters that play important physiological and pharmacological roles. At the blood-brain barrier (BBB), P-gp and BCRP function cooperatively as the...
Engineering a BMP2-risedronate complex with sustained release for osteoporosis therapy [0.03%]
工程化BMP2-利塞磷酸盐复合物以用于骨质疏松症治疗
Sang-Ok Jeon,Shrawani Lamichhane,Dong-Ho Oh et al.
Sang-Ok Jeon et al.
Human bone morphogenetic protein 2 (BMP2) is a key inducer of osteogenesis; however, conventional delivery systems often result in burst release and adverse effects. To address this limitation, we fabricated an ionic complex of BMP2 with th...
Histone lactylation in gastrointestinal cancers: developing immunotherapeutic drugs targeting epigenetics [0.03%]
胃肠癌症中的组蛋白乳酸化：开发靶向表观遗传学的免疫治疗药物
Mingyao Huang
Mingyao Huang
Gastrointestinal cancers (GICs) remain a major global health burden due to their aggressive nature, therapeutic resistance, and immunosuppressive tumor microenvironment (TME). Histone lactylation, a novel epigenetic modification driven by t...
p62/SQSTM1 signaling nexus and orchestration of ERK and mTOR pathways are crucial for Bacoside A- induced autophagy-mediated apoptosis in chronic myelogenous leukemia [0.03%]
自噬介导的慢性髓系白血病中贝那普利诱导的细胞凋亡的p62/SQSTM1信号枢纽及ERK和mTOR通路的协调作用至关重要
Sweta Kundu,Suvodeep Saha,Suparna Ghosh et al.
Sweta Kundu et al.
Bacoside A (BCA), a triterpenoid saponin isolated from Bacopa monnieri, exhibits diverse pharmacological properties, including neuroprotective, hepatoprotective, anti-stress, anti-inflammatory, and anti-ulcer effects. In the present study, ...
Human YKL-40 antibody alleviates atopic dermatitis-like skin inflammation by inhibiting exosome secretion via the JAK3/STAT6 pathway [0.03%]
人源YKL-40抗体通过抑制JAK3/STAT6信号通路减少外泌体分泌以缓解特应性皮炎炎症
Jun Sang Yu,Tae Hun Kim,Sung Sik Park et al.
Jun Sang Yu et al.
Atopic dermatitis (AD) is an inflammatory skin disease that produces a variety of inflammatory cytokines and chemokines. Chitinase-3-like protein 1 (CHI3L1, YKL-40) significantly contributes to AD-associated inflammatory response and is hig...
Advances in JNK inhibitor development: therapeutic prospects in neurodegenerative diseases and fibrosis [0.03%]
JNK抑制剂开发进展：神经退行性疾病和纤维化治疗前景
Swapnil P Bhujbal,Jung-Mi Hah
Swapnil P Bhujbal
c-Jun N-terminal kinases (JNKs), a subfamily of mitogen-activated protein kinases (MAPKs), are key mediators of cellular responses to environmental stress, inflammation, and apoptotic signals. The three isoforms-JNK1, JNK2, and JNK3 exhibit...
Enhancer regulation in cancer: from epigenetics to m6A RNA modification [0.03%]
癌症中的增强子调控：从表观遗传学到m6A RNA修饰
Arathy Vasukutty,Poshan Yugal Bhattarai,Hong Seok Choi
Arathy Vasukutty
Enhancers are crucial cis-regulatory DNA elements that regulate gene transcription by interacting with promoters, often over long genomic distances. Unlike promoters, their activity is independent of orientation or proximity to the gene. Ac...
NRF2 activation in cancer and overview of NRF2 small molecule inhibitors [0.03%]
癌症中的NRF2活化及NRF2小分子抑制剂综述
Hoang Hai Ngo,Bo-Yeong Yu,Jeong-Eun Lee et al.
Hoang Hai Ngo et al.
NRF2 is a redox-sensitive transcription factor that activates the expression of phase II detoxifying and antioxidant enzymes. In addition to maintaining redox homeostasis, NRF2 regulates various other processes, including metabolism, stem c...
A novel multi-target compound mitigates amyloid plaques, synaptic deficits, and neuroinflammation in Alzheimer's disease models [0.03%]
一种新型多靶点化合物可缓解阿尔茨海默病模型中的淀粉样蛋白斑块、突触缺陷和神经炎症
Yeongyeong Lee,Sukmin Han,Jeongmi Lee et al.
Yeongyeong Lee et al.
Alzheimer's disease (AD) is characterized by progressive cognitive decline, amyloid plaque accumulation, synaptic dysfunction, and neuroinflammation. This study reports the therapeutic potential of (S)-4-amino-5,5-difluoro-N'-methyl-N'-phen...