Integrative multi-omics analyses reveal nuclear noncoding RNA-mediated regulatory landscape in Alzheimer's disease [0.03%]
整合多组学分析揭示了阿尔茨海默病中细胞核非编码RNA介导的调控图谱
Sumin Yang,Sung-Hyun Kim,Jeonghyeon Choi et al.
Sumin Yang et al.
Alzheimer's disease (AD) progression involves complex molecular mechanisms underlying neuronal dysfunction. While emerging evidence on long noncoding RNAs (lncRNAs) is accumulating, the relevance of nuclear noncoding RNAs (ncRNAs) to neurod...
Tumor organoid platform design for drug response modeling: culture architecture, microenvironmental complexity, and AI-assisted readouts [0.03%]
肿瘤类器官平台设计用于药物反应建模：培养体系、微环境复杂性及人工智能辅助读出系统
Eun Ah Shin,Won-Cheol Jeong,Ye-Won Kim et al.
Eun Ah Shin et al.
Tumor organoids preserve the cellular heterogeneity and structural complexity of native tumors, providing robust platforms for mechanistic studies, preclinical drug testing, and translational oncology research. However, their predictive per...
Acetylation-dependent regulation of FOX-Ku interaction by GCN5-SIRT1 axis controls non-homologous end-joining DNA repair [0.03%]
GCN5-SIRT1轴依赖乙酰化调控FOX-Ku相互作用以控制非同源末端连接DNA修复
Yongyang Luo,Kangseok Lee,Jeehyeon Bae
Yongyang Luo
DNA double-strand breaks (DSBs) represent a major threat to genomic integrity. DSBs are primarily repaired through homologous recombination (HR) and non-homologous end-joining (NHEJ). The Ku complex, composed of XRCC5 and XRCC6, initiates N...
Exercise-induced myokines in metabolic regulation: mechanisms, mimetics, and translational potential [0.03%]
运动诱导的肌肉因子在代谢调节中的作用：机制、模拟物和转化潜力
Muhammad Arif Aslam,Jongmin Lee,T Scott Bowen et al.
Muhammad Arif Aslam et al.
Skeletal muscle, once regarded solely as a contractile tissue, is now recognized as a dynamic endocrine organ that secretes exercise-induced myokines-bioactive peptides with autocrine, paracrine, and endocrine functions. These myokines coor...
eHsp90α enhances breast cancer cell invasion by activating the LRP1-EGFR/AKT-twist/snail signaling axis in cancer-associated fibroblasts [0.03%]
癌相关成纤维细胞中的eHsp90α通过激活LRP1-EGFR/AKT-twist/snail信号轴促进乳腺癌细胞侵袭
Su Jin Cho,Se-Hee Yoon,Chang Gyo Park et al.
Su Jin Cho et al.
Extracellular heat shock protein 90 alpha (eHsp90α) has been implicated in promoting cancer cell invasion and metastasis. However, the role of eHsp90α in the tumor microenvironment remains poorly understood. In the present study, we provi...
Liver organoids for chemical risk assessment: biological fidelity, standardization, and context-of-use frameworks [0.03%]
用于化学风险评估的肝器官体：生物学保真度、标准化和用途框架
Yongbo Shin,Hye-Ran Moon,You Mie Lee et al.
Yongbo Shin et al.
Liver organoids are emerging as human-relevant three-dimensional in vitro systems for chemical safety assessment, however, their application value depends on their ability to generate decision-ready evidence within clearly defined context-o...
M2 microglial exosomal miR-1949 ameliorates sepsis-associated encephalopathy through DKK1/Wnt/β-catenin-mediated microglial repolarization [0.03%]
小胶质细胞源外泌体miR-1949通过DKK1/Wnt/β-catenin介导的小胶质细胞重极化改善脓毒症相关性脑病
Yue Cao,Zhaoyang Li,Xiangqi Liu et al.
Yue Cao et al.
Sepsis-associated encephalopathy (SAE), the most common neurological complication of sepsis with high mortality, lacks effective treatments. Although microglia play a significant role in SAE pathogenesis, the mechanisms of M2 microglial exo...
Therapeutic potential of glycyrrhizic acid in inflammation-related diseases: from HMGB1-oriented molecular insights to preclinical application [0.03%]
甘草甜素在炎症相关性疾病治疗中的潜力：从HMGB1分子机制到临床前应用研究
Yicheng Hu,Jiani Hou,Yifeng Cai et al.
Yicheng Hu et al.
Chronic inflammation drives the pathogenesis of diverse disorders, yet current anti-inflammatory strategies often lack mechanistic selectivity. Glycyrrhizic acid (GL), a major triterpenoid saponin from Glycyrrhiza species, exhibits broad an...
Novel hasubanan alkaloids and dimers from Stephania japonica var. discolor: phytochemical profile and anti-neuroinflammatory activity [0.03%]
Stephania japonica 变种的哈斯班纳生物碱和二聚体：植物化学特征及抗神经炎症活性
Yingjie Wang,Jiao Xiao,Yan Mi et al.
Yingjie Wang et al.
Using a 1H-NMR-guided isolation approach, twelve novel hasubanan alkaloids, bishernsubanins A-D (1-4) and hernsubanines G-N (5-12), along with eight known monomeric analogues (13-20), were isolated from Stephania japonica var. discolor. Not...
Nobiletin attenuates LPS-induced acute lung injury via a STING-dependent signaling pathway [0.03%]
诺倍亭通过STING依赖性信号通路减轻LPS诱导的急性肺损伤
Ranran Chen,Wenwen Zhu,Ruyin Zheng et al.
Ranran Chen et al.
Previous studies have shown that Quzhou Fructus Aurantii extract (QFAEE) ameliorates lipopolysaccharide (LPS)-induced acute lung injury (ALI) by modulating the Stimulator of interferon genes (STING) pathway. Nevertheless, the mechanisms und...