Nobiletin attenuates LPS-induced acute lung injury via a STING-dependent signaling pathway [0.03%]
诺倍亭通过STING依赖性信号通路减轻LPS诱导的急性肺损伤
Ranran Chen,Wenwen Zhu,Ruyin Zheng et al.
Ranran Chen et al.
Previous studies have shown that Quzhou Fructus Aurantii extract (QFAEE) ameliorates lipopolysaccharide (LPS)-induced acute lung injury (ALI) by modulating the Stimulator of interferon genes (STING) pathway. Nevertheless, the mechanisms und...
Cinnamic acid attenuates Klebsiella pneumoniae virulence by suppressing capsule biosynthesis [0.03%]
香豆酸通过抑制荚膜生物合成来减轻肺炎克雷伯氏菌的致病性
Huaizhi Yang,Ying Ding,Xiangzhu Xu et al.
Huaizhi Yang et al.
The widespread dissemination and serious clinical consequences of hypervirulent Klebsiella pneumoniae (hvKP), an encapsuled gram-negative pathogenic bacterium characterized by its specific virulence factor hypermucoviscosity (HMV), is becom...
Lactylation-regulated ferroptosis: mechanisms, disease associations, and therapeutic strategies [0.03%]
乳酰化调控的铁死亡：机制、关联疾病和治疗策略
Yun Lei,Si-Qi Ding,Kai-Qiang Li et al.
Yun Lei et al.
Lactylation, as a novel post-translational modification, plays a key role in gene transcription and protein expression, serving as an important link between cellular metabolism and functional regulation. Ferroptosis is a regulatory form of ...
Modulation of mitochondrial DNA copy number: therapeutic potential of phytochemicals and plant extracts-a comprehensive review [0.03%]
线粒体DNA拷贝数的调节：植物化学物质和植物提取物的治疗潜力——全面综述
Maria Rosaria Perri,Annamaria Cerantonio,Maria Grazia Cipriani et al.
Maria Rosaria Perri et al.
Mitochondrial DNA copy number (mtDNA-CN) is a critical marker of mitochondrial health and plays a key role in cellular bioenergetics. Alterations in mtDNA-CN have been associated with aging, metabolic disorders and neurodegenerative disease...
Vitamin D remodels the tumor microenvironment to suppress gastric cancer progression through cancer-associated fibroblasts-secreted exosomal miR-378c targeting KDSR [0.03%]
维生素D通过癌相关成纤维细胞分泌的外泌体miR-378c作用于KDSR来重构肿瘤微环境从而抑制胃癌进展
Qianxiu Li,Yubin Liu,Linguo Zhong et al.
Qianxiu Li et al.
Gastric cancer (GC) is a malignant neoplasm displaying highly cancer-related mortality globally. Although our previous studies have confirmed that vitamin D possessed a direct anti-cancer effect on GC cells, the regulatory role of vitamin D...
Evaluating the clinical effects of GLP-1 receptor agonists for Alzheimer's and Parkinson's diseases using minimal clinically important difference: systematic review and meta-analysis [0.03%]
利拉鲁肽治疗阿尔茨海默病和帕金森病的临床效果评价：系统综述和meta分析
Yomna Elghanam,Eunyoung Kim
Yomna Elghanam
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are promising candidates for Alzheimer's disease (AD) and Parkinson's disease (PD). However, their effects in non-diabetic populations, independent of metabolic confounding, remain unclea...
Natural compounds targeting inflammatory signaling and cell adhesion molecules in ischemic acute kidney injury [0.03%]
针对缺血性急性肾损伤中炎症信号通路和细胞黏附分子的天然化合物
Sally A Fahim,Ahmed M El-Dessouki,Nada Osama et al.
Sally A Fahim et al.
Ischemic acute kidney injury (AKI) remains a major clinical challenge, characterized by high morbidity, mortality, and a substantial risk of progression to chronic kidney disease. Accumulating evidence indicates that ischemic AKI is not mer...
Mitochondrial dysfunction in endothelial senescence: implications for vascular remodeling and therapeutic strategies [0.03%]
线粒体功能障碍与内皮衰老：对血管重塑及治疗策略的意义
Wen Li,Jinteng Liu,Xinyin Fu et al.
Wen Li et al.
Vascular remodeling (VR) is a structural and functional adaptation of the vessel wall to hemodynamic, metabolic, and inflammatory stress. When persistent and dysregulated, it contributes to the progression of atherosclerosis, hypertension, ...
Leptin sensitizes hepatocytes to endotoxin toxicity via interleukin-1β signaling and drives adaptive immune activation in the liver [0.03%]
瘦素通过白细胞介素-1β信号增强肝细胞内内毒素毒性并促进肝脏适应性免疫活化
Ananda Baral,Pil-Hoon Park
Ananda Baral
Leptin, an adipose tissue-derived hormone, regulates multiple aspects of hepatic physiology beyond its well-established metabolic functions. Accumulating evidence indicates that leptin influences hepatocyte viability, yet its role in endoto...
Glycosides in Meliaceae and Rutaceae sources: phytochemistry and pharmacological activities [0.03%]
楝科和芸香科糖苷的植物化学和药理活性
Risma Rahmawati,Al Arofatus Naini,Sofa Fajriah et al.
Risma Rahmawati et al.
Glycosides are widely distributed plant secondary metabolites and constitute an important source of chemical diversity in Meliaceae and Rutaceae families. Therefore, this review aimed to compile glycosides reported from Meliaceae and Rutace...