A novel dual CDC25-HDAC inhibitor suppresses glioblastoma progression via chromosomal passenger complex disruption [0.03%]
一种新型的CDC25-HDAC抑制剂通过破坏染色体乘客复合物来抑制胶质母细胞瘤的发展
Richa Upadhyay,Bidyadhar Sethy,Wen-Bin Yang et al.
Richa Upadhyay et al.
Glioblastoma (GBM) is a highly aggressive and therapeutically challenging brain tumor characterized by poor prognosis, rapid recurrence, and resistance to standard treatments such as temozolomide (TMZ). Novel therapeutic strategies that tar...
Bacteriophage antimicrobial therapy: From mechanism exploration to biomedical applications [0.03%]
噬菌体抗菌治疗：从作用机制研究到生物医学应用
Ling Zhao,Xiaohua Li,Hailin Cong et al.
Ling Zhao et al.
In recent years, due to the widespread use of antibiotics, even abuse, the problem of bacterial resistance is becoming more and more serious. Finding new antimicrobial agents and therapeutic methods has become a difficult problem that needs...
Gut-eye axis in ophthalmic diseases: Focus on ocular neurodegeneration [0.03%]
眼病中的肠-眼轴：眼部神经退行性病变:focus
Lujia Zhou,Yan Ma,Xiumiao Li et al.
Lujia Zhou et al.
Ocular neurodegeneration comprises a group of complex processes that severely affect visual function and is recognized as a key pathogenetic process in a variety of blinding ocular diseases, including glaucoma, diabetic retinopathy, age-rel...
Dual targeting of BCMA and B7-H3 with CAR T cells and bispecific protein engagers enhances anti-myeloma activity [0.03%]
双靶向BCMA和B7-H3的CAR-T细胞和双特异性蛋白衔接物可增强抗多发性骨髓瘤活性
Naeramit Sontayananon,Pornpimon Yuti,Nunghathai Sawasdee et al.
Naeramit Sontayananon et al.
Background: B cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T cells have shown remarkable activity in relapsed/refractory multiple myeloma (R/R MM). However, therapeutic resistance often arises d...
Quantitative and qualitative comparison of mRNA loading techniques into extracellular vesicles [0.03%]
不同mRNA装载到外泌体中方法的定性和定量比较研究
Mònica Guarro,Stijn van Veen,Salvador Borrós et al.
Mònica Guarro et al.
Extracellular vesicles (EVs) are increasingly recognized as natural therapeutic delivery systems (DDS). A critical challenge in realizing this potential is the loading of nucleic acids, particularly mRNA, a high molecular weight and very se...
Polydopamine-coated gold nanoparticles promote cartilage regeneration and alleviate osteoarthritis in rats [0.03%]
聚多巴胺包被的金纳米颗粒促进软骨再生并缓解大鼠骨关节炎
Sujin Choi,Sung-Sahn Lee,Junwon Choi et al.
Sujin Choi et al.
Background: Osteoarthritis (OA) is characterized by progressive degeneration of articular cartilage, and current treatments often result in suboptimal fibrous cartilage repair. This study explored the effects of polydopam...
Calcium blockers protect against sensory epithelial damage and hearing loss in Cx26-cKO mice [0.03%]
钙通道阻滞剂可保护Cx26-cKO小鼠感觉上皮免受损伤和听力下降的影响
Xue Bai,Bing Liao,Wen-Hui Hu et al.
Xue Bai et al.
Mutations in the GJB2 gene represent one of the most prevalent genetic causes of non-syndromic sensorineural hearing loss. Accumulating evidence suggests that degeneration of the cochlear sensory epithelium and developmental abnormalities i...
Targeting the polyol pathway in NSCLC: Trans-(±)-kusunokinin demonstrates anti-migratory and survival benefits in in vitro and in vivo models [0.03%]
靶向肺腺癌中的山梨醇途径：反式-(±)-kusunokinin在体内外模型中表现出抗迁移和生存益处
Tanotnon Tanawattanasuntorn,Paradesi Naidu Gollavilli,Adriana Martinez Turtos et al.
Tanotnon Tanawattanasuntorn et al.
Trans-(±)-kusunokinin (KU), a potential anticancer agent, has been reported as an AKR1B1 inhibitor, a key enzyme in the polyol pathway that converts glucose to sorbitol and subsequently to fructose via sorbitol dehydrogenase (SORD). This p...
Systemic and skeletal muscle metabolic signatures associated with early insulin resistance in just-weaned non-obese Goto-Kakizaki diabetic rats [0.03%]
新断奶的非肥胖GK糖尿病大鼠早期胰岛素抵抗的相关系统和骨骼肌代谢标志物
Thyerre Santana da Costa,João Guilherme de Moraes Pontes,Gonzalo García Delgado Garcia et al.
Thyerre Santana da Costa et al.
The Goto-Kakizaki (GK) rat is a well-established experimental model for spontaneous non-obese type 2 diabetes mellitus (T2DM). However, the mechanisms underlying the early onset of the disease remain poorly understood. In this study, we inv...
Corrigendum to "High potency of magnetic iron oxide nanoparticles covered by piroctone olamine against cystic echinococcosis" [Biomed. Pharmacother., 2023 (161) 114536] [0.03%]
“/piroctone olamine包被的磁性铁氧化物纳米颗粒抗细粒棘球蚴病活性较强”一文勘误通知书
Yosra Raziani,Koroush Cheraghipour,Mojtaba Shakibaie et al.
Yosra Raziani et al.