Steroid-loaded Avidin-Nucleic-Acid-Nano-Assemblies reduce hepatic fibrosis modulating Kupffer cells in primary biliary cholangitis [0.03%]
载激素的avidin-核酸-纳米组装体通过调节原发性胆汁性胆管炎中的 kupffer 细胞减少肝纤维化
Martina Bruna Violatto,Manuela Vitulo,Elisa Schiavon et al.
Martina Bruna Violatto et al.
Primary biliary cholangitis (PBC) is the most common life-long autoimmune liver disease arising from a biliary epithelial activation to a complex evolving cascade of immune-mediated injury, leading to inflammation and fibrosis and ultimatel...
Cabazitaxel and camptothecin co-loaded in pH-sensitive transferrin-targeted, PEGylated cholesterol-based poly(amidoamine) dendrimers as a synergistic combination for prostate cancer [0.03%]
共载多西他赛和喜树碱的pH敏感性转铁蛋白靶向聚酰胺-胺类胆固醇衍生物树状大分子作为协同治疗前列腺癌的新载体系统研究
Musa Albatsh,Yousef Ijjeh,Nowar Alsarayreh et al.
Musa Albatsh et al.
The clinical utility of combining cabazitaxel (CBZ) and camptothecin (CPT) for advanced prostate cancer is hindered by emerging drug resistance and the absence of optimized nanocarriers for co-delivery. We investigated the potential of nove...
Targeting PNPLA3 I148M variant in MASLD: Cell-type specific mechanisms and precision therapy opportunities [0.03%]
靶向PNPLA3 I148M变异在MASLD中的细胞类型特异性机制和精准治疗机会
Huainan Bu,Lin Liu,Helin Liu et al.
Huainan Bu et al.
The PNPLA3 I148M variant is the primary genetic risk factor for metabolic dysfunction-associated steatotic liver disease, representing the most promising target for interventions in this increasingly prevalent disease. In this review, we de...
Fluorinated isoindolinone-amino acid hybrids possessing antiproliferative and antitumor activity in vitro and in vivo [0.03%]
一类具有抗增殖及体内抗肿瘤活性的氟取代异靛红-氨基酸衍生物杂合化合物
Soma Mandal,Rajat Choudhary,A A I Parvaj Laskar et al.
Soma Mandal et al.
The limited efficacy and resistance associated with current anticancer therapies necessitate the development of novel agent, particularly for aggressive malignancies. In this study, a series of fluorine-substituted isoindolinone-amino acid ...
Investigation of the healing effects of phenylboronic acid and exosome on the TGF-β-Smad/REDD1 pathway in aspartame-induced liver damage in BALB/c type mice [0.03%]
苯硼酸和外泌体对阿斯巴甜致BALB/c小鼠肝损伤TGF-β-Smad/REDD1通路修复作用的实验研究
Begum Sahin,Talat Yasin Acar,Aysenur Kurt et al.
Begum Sahin et al.
Aspartame, a widely used artificial sweetener, has raised concerns regarding its potential hepatotoxicity under chronic exposure. This study aimed to investigate the protective roles of phenylboronic acid (PBA) and exosomes (Exo) againist c...
Clinical stage anti-RGMa monoclonal antibody elezanumab promotes bladder recovery and neuroplasticity after traumatic spinal cord injury [0.03%]
临床阶段抗RGMa单克隆抗体elezanumab可促进脊髓损伤后的膀胱恢复和神经可塑性
Andrea J Mothe,Magdy Hassouna,Christopher Ahuja et al.
Andrea J Mothe et al.
Spinal cord injury (SCI) causes severe and often permanent neurological deficits, including neurogenic lower urinary tract dysfunction. Although restoration of bladder function is a major clinical priority after SCI and would profoundly imp...
Suprachoroidal hydrogel systems for posterior ocular therapy: Design principles, therapeutic applications, and translational challenges [0.03%]
适用于眼后段治疗的超巩膜羟基凝胶系统：设计原理、治疗应用和转化挑战
Zainab Ahmadian,Hirokazu Kaji
Zainab Ahmadian
Suprachoroidal delivery offers a minimally invasive route for targeting the choroid and retina, while reducing complications related to conventional ocular delivery methods. This review focuses on hydrogels engineered for the suprachoroidal...
Chemical synthesis and biological activity of semisynthetic derivatives against Chagas disease and leishmaniasis composed of fragments of natural products and 1,2,3-triazine 1-oxide scaffold [0.03%]
基于天然产物片段和1,2,3-三嗪1-氧化物骨架的抗恰加斯病和利什曼病半合成衍生物的化学合成及生物学活性研究
Diana V Navarrete-Carriola,Adriana Moreno-Rodríguez,Benjamín Nogueda-Torres et al.
Diana V Navarrete-Carriola et al.
Chagas disease and leishmaniasis are neglected diseases caused by Trypanosoma cruzi and Leishmania sp., respectively, leading to morbidity and mortality worldwide and affecting more than 6 million people per year. Despite the availability o...
Adaptive nanocarriers targeting tumor systemic intelligence: A paradigm to overcome systemic barriers in precision drug delivery [0.03%]
针对肿瘤全身智能的适应性纳米载体：精准药物传输克服全身屏障的新范例
Fansu Meng,Majid Sharifi,Laila Abdulmohsen Jaragh-Alhadad et al.
Fansu Meng et al.
Biological barriers remain a primary limitation to effective cancer therapy, restricting drug delivery, distribution, and therapeutic efficacy across tumor sites. These barriers arise from a complex and dynamic interplay between tumor- and ...
Development and characterization of [47Sc]Sc-NOTA-trastuzumab for targeted radiotherapy in primary and metastatic HER2 + breast cancer [0.03%]
47Sc-SC-NOTA-曲妥珠单抗的开发与表征用于原发和转移性HER2阳性乳腺癌的靶向放疗
Patrick N Song,Shelbie J Cingoranelli,Sharmila Sridhar et al.
Patrick N Song et al.
Purpose: This study investigates the potential of [47Sc]Sc-NOTA-trastuzumab as a novel targeted radionuclide agent in HER2 + breast cancer. Targeted radionuclide therapy offers a promising approach for enhanced delivery a...