FUS-driven zebrafish model of ALS identifies tribenzylamine as a candidate modulator of ALS-associated pathology [0.03%]
ALS相关病理学靶向调节物TBZA的遗传 screen及作用机制研究
Yongbo Seo,Jeonghyeon Lee,Yunkyoung Lee et al.
Yongbo Seo et al.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor neuron loss and declining motor function; however, effective therapies remain limited. To support unbiased therapeutic discovery, we aime...
Anticancer, hepatoprotective, and mechanistic evidence of chlorogenic acid in liver cancer: A systematic review [0.03%]
氯ogenic酸在肝癌中的抗肿瘤、肝脏保护及机制研究的系统性综述
Amaya Pérez Pérez,Felipe Zamorano Peña,Keila Torres et al.
Amaya Pérez Pérez et al.
Background: Liver cancer, particularly hepatocellular carcinoma (HCC), remains a leading cause of cancer-related mortality worldwide. Chlorogenic acid (CGA), a dietary polyphenol abundant in coffee and plant-based foods, ...
Natural compounds as epigenetic modulators in gynaecological cancers: From chemoresistance to precision oncology [0.03%]
天然化合物作为妇科癌症中的表观遗传调节剂：从化疗耐药到精准肿瘤学
Prakash Lingasamy,Blessy Kiruba,Santhosh Rajakumar et al.
Prakash Lingasamy et al.
Background: Gynaecological cancers, including ovarian, cervical, and endometrial malignancies, remain major causes of cancer-related morbidity and mortality because of tumour heterogeneity, recurrence, and therapeutic res...
TGR5 activation impairs lung natural killer cell function and promotes bile acid-mediated injury in metabolic liver disease [0.03%]
TGR5激活损害肺部NK细胞功能并促进代谢性肝病中胆汁酸介导的损伤
Alaa Mohammed Felel,Mohammad Jaber,Hanin Takhman et al.
Alaa Mohammed Felel et al.
Introduction and aim: Bile acids (BAs) contribute to acute lung injury (ALI), yet their effects on pulmonary immune cells remain unclear. This study investigated whether elevated hepatic BA levels in metabolic dysfunction...
Pleiotropic effects of direct oral anticoagulants on the coagulation-inflammation-endothelium axis: A phenotype-stratified narrative review [0.03%]
直接口服抗凝血药对凝血-炎症-血管内皮轴的多效性影响：一种表型分类叙述性综述
Łukasz Wołowiec,Weronika Wesołowska,Katarzyna Skibicka et al.
Łukasz Wołowiec et al.
Aims: Direct oral anticoagulants (DOACs) - dabigatran (a thrombin inhibitor) and rivaroxaban, apixaban, and edoxaban (factor Xa [FXa] inhibitors) - modify oxidative stress, endothelial inflammation, and barrier integrity ...
Acetonic extract of Saskatoon berry attenuates amyloid-associated neurotoxicity in cellular and Drosophila melanogaster Alzheimer's disease models [0.03%]
Saskatoon浆果醋提取物通过细胞和黑腹果蝇阿尔茨海默病模型中的淀粉样蛋白相关神经毒性作用发挥神经保护功能
Lucas Matos Martins Bernardes,Alexandre Souza Marquez,Fernanda Naves Araújo do Prado Mascarenhas et al.
Lucas Matos Martins Bernardes et al.
Saskatoon berry (Amelanchier alnifolia) is rich in polyphenols known to modulate oxidative stress and neuroinflammation, key mechanisms involved in Alzheimer's disease (AD), yet its neuroprotective potential in this context remains unexplor...
Efficacy of natural products in the treatment of melasma: A systematic review [0.03%]
天然产品治疗黄褐斑疗效的系统评价
Maria Thereza Morais,Talita Lorena Nascimento Gonçalves,Luise de Paula Soares et al.
Maria Thereza Morais et al.
Melasma is a chronic, relapsing hypermelanosis characterized by symmetric facial pigmentation and high recurrence rates. Natural products have been investigated for their antioxidant, anti-inflammatory, and depigmenting properties. This sys...
From in vitro antimicrobial activity to enhanced innate immunity in vivo: cornelian cherry (Cornus mas L.) fruit extracts correct diabetic leukocyte dysfunction through immunometabolic modulation [0.03%]
从体外抗菌活性到体内增强先天免疫：Cornus mas L.果实提取物通过免疫代谢调节纠正糖尿病白细胞功能障碍
Anna Moroz,Iryna Brodyak,Taras Peretyatko et al.
Anna Moroz et al.
The increasing prevalence of antimicrobial resistance and diabetes-associated immune dysfunction necessitates the development of novel natural agents with antimicrobial and immunomodulatory properties. Cornelian cherry fruits are rich in bi...
Engineered polymer micelles with tunable gas release for effective reduction of local fat deposits [0.03%]
具有可调气体释放功能的工程化聚合物胶束有效减少局部脂肪沉积
Choonggu Kim,Yun-Chan Lee,In Young Lee et al.
Choonggu Kim et al.
Demand is rising for non-surgical, site-specific fat reduction. This study presents fully organic biodegradable polymer micelles capable of intrinsic carbon dioxide (CO2) gas generation for adipocytolysis. Amphiphilic methoxy-poly(ethylene ...
Tuning the oxidation of boron nitride for enhancing its antitumor activity [0.03%]
通过调节氮化硼的氧化程度来增强其抗肿瘤活性
Lucas Souyris,Ingrid Charodin,Fanny Salmeron et al.
Lucas Souyris et al.
A paramount challenge in orthopedic research is the design of next-generation multifunctional biomaterials that can simultaneously promote bone regeneration and treat pathological conditions, such as bone tumors. Here, we investigated hexag...