Dual bispecific protein engager-armed T cells targeting BCMA and B7-H3 overcome antigen heterogeneity in multiple myeloma [0.03%]
双特异性蛋白武装的T细胞靶向BCMA和B7-H3可克服多发性骨髓瘤中的抗原异质性
Thanida Chanpong,Nunghathai Sawasdee,Kamonlapat Supimon et al.
Thanida Chanpong et al.
Multiple myeloma (MM) remains an incurable plasma cell malignancy, with most patients ultimately progressing to relapsed or refractory MM (RRMM) despite therapeutic advances. Antigen heterogeneity and immune escape, particularly the loss of...
Evaluating the cardiometabolic impact of Janus-kinase inhibition: An experimental analysis of Tofacitinib's therapeutic potential in a rodent model [0.03%]
Janus激酶抑制的 cardiometabolic 影响评估：Tofacitinib 在啮齿动物模型中的治疗潜力实验分析
Vera Tarjányi,Anna Szilágyi,Réka Szekeres et al.
Vera Tarjányi et al.
Background: Rheumatoid arthritis (RA) is the most prevalent non-infectious inflammatory disorder, often associated with comorbidities such as cardiovascular alterations and metabolic syndrome. These comorbidities signific...
Retraction notice to "Targeting neutrophils extracellular traps, a promising anti-thrombotic therapy for natural products from traditional Chinese herbal medicine" [Biomedicine & Pharmacotherapy 179 (2024) 117310] [0.03%]
撤稿通知：“针对天然中药产物的中草药抗血栓疗法——靶向 neutrophils 外源性陷阱[Biomedicine & Pharmacotherapy 179 (2024) 117310]]
Wei Lei,Xiao Li,Shanze Li et al.
Wei Lei et al.
Tailoring pH-responsive charge-conversional interfaces in ionizable lipid-based nanoliposomes for synchronized co-delivery and synergistic therapy of triple-negative breast cancer [0.03%]
通过调节离子化脂质基纳脂粒的pH响应电荷转换界面实现三阴性乳腺癌药物协同治疗
Yeji Choi,Ki-Hoon Choung,Minki Jin et al.
Yeji Choi et al.
Combination chemotherapy is often limited by the distinct physicochemical properties and intracellular behaviors of individual drugs. This limitation leads to poorly coordinated delivery in tumor tissues. In this study, pH-responsive ioniza...
Corrigendum to "Aerobic conditioning and ginsenoside modulation modify molecular resilience in middle-aged rats: Differential effects of individual and combined interventions" [Biomed. Pharmacother. 201 (2026) 119758] [0.03%]
“有氧锻炼和人参皂苷调节改变中年大鼠分子耐受性：单独和联合干预的差异效应”一文的勘误项 [Biomed. Pharmacother. 201 (2026) 119758]
Zahra Olfat Noubari,Jabbar Bashiri,Mohammad Mostafa Pourseif et al.
Zahra Olfat Noubari et al.
Steroid-loaded Avidin-Nucleic-Acid-Nano-Assemblies reduce hepatic fibrosis modulating Kupffer cells in primary biliary cholangitis [0.03%]
载激素的avidin-核酸-纳米组装体通过调节原发性胆汁性胆管炎中的 kupffer 细胞减少肝纤维化
Martina Bruna Violatto,Manuela Vitulo,Elisa Schiavon et al.
Martina Bruna Violatto et al.
Primary biliary cholangitis (PBC) is the most common life-long autoimmune liver disease arising from a biliary epithelial activation to a complex evolving cascade of immune-mediated injury, leading to inflammation and fibrosis and ultimatel...
Cabazitaxel and camptothecin co-loaded in pH-sensitive transferrin-targeted, PEGylated cholesterol-based poly(amidoamine) dendrimers as a synergistic combination for prostate cancer [0.03%]
共载多西他赛和喜树碱的pH敏感性转铁蛋白靶向聚酰胺-胺类胆固醇衍生物树状大分子作为协同治疗前列腺癌的新载体系统研究
Musa Albatsh,Yousef Ijjeh,Nowar Alsarayreh et al.
Musa Albatsh et al.
The clinical utility of combining cabazitaxel (CBZ) and camptothecin (CPT) for advanced prostate cancer is hindered by emerging drug resistance and the absence of optimized nanocarriers for co-delivery. We investigated the potential of nove...
Targeting PNPLA3 I148M variant in MASLD: Cell-type specific mechanisms and precision therapy opportunities [0.03%]
靶向PNPLA3 I148M变异在MASLD中的细胞类型特异性机制和精准治疗机会
Huainan Bu,Lin Liu,Helin Liu et al.
Huainan Bu et al.
The PNPLA3 I148M variant is the primary genetic risk factor for metabolic dysfunction-associated steatotic liver disease, representing the most promising target for interventions in this increasingly prevalent disease. In this review, we de...
Fluorinated isoindolinone-amino acid hybrids possessing antiproliferative and antitumor activity in vitro and in vivo [0.03%]
一类具有抗增殖及体内抗肿瘤活性的氟取代异靛红-氨基酸衍生物杂合化合物
Soma Mandal,Rajat Choudhary,A A I Parvaj Laskar et al.
Soma Mandal et al.
The limited efficacy and resistance associated with current anticancer therapies necessitate the development of novel agent, particularly for aggressive malignancies. In this study, a series of fluorine-substituted isoindolinone-amino acid ...
Investigation of the healing effects of phenylboronic acid and exosome on the TGF-β-Smad/REDD1 pathway in aspartame-induced liver damage in BALB/c type mice [0.03%]
苯硼酸和外泌体对阿斯巴甜致BALB/c小鼠肝损伤TGF-β-Smad/REDD1通路修复作用的实验研究
Begum Sahin,Talat Yasin Acar,Aysenur Kurt et al.
Begum Sahin et al.
Aspartame, a widely used artificial sweetener, has raised concerns regarding its potential hepatotoxicity under chronic exposure. This study aimed to investigate the protective roles of phenylboronic acid (PBA) and exosomes (Exo) againist c...