Amsacrine modifies action potential configuration without its prolongation via the blockade of multiple ion currents in canine ventricular cells [0.03%]
胺硫霉素通过阻断多种离子电流改变动作电位的形态而不延长犬心室肌细胞的动作电位
József Óvári,Zsigmond Máté Kovács,János Magyar et al.
József Óvári et al.
Amsacrine is an antineoplastic agent for acute lymphoblastic leukemia. It contains methanesulfonamide group -similar to hERG/IKr inhibitors like E-4031 and dofetilide-therefore may exert cardiac arrhythmias. Although amsacrine inhibits expr...
Modelling targeted therapy efficacy in NRAS mutant conjunctival melanoma [0.03%]
NRAS突变conjunctival黑色素瘤靶向治疗有效性的建模分析
Eetu Välimäki,Erika Alanne,Janne Suhonen et al.
Eetu Välimäki et al.
Conjunctival melanoma (CoM) is an ultra-rare ocular melanoma that originates from transformed melanocytes of the conjunctiva. CoM shares a common embryonic cell of origin as cutaneous melanoma and manifests as highly aggressive malignancy. ...
Translational consistency of gene therapy strategies targeting inflammation in atrial fibrillation's management [0.03%]
针对房颤管理中靶向炎症的基因治疗策略的转化一致性
Maïssa Zemmouchi,Aseel El-Fermawi,Anya Benagdi et al.
Maïssa Zemmouchi et al.
Atrial fibrillation (AF) is the most common cardiac rhythm disorder. AF risk factors include pathological ageing, hypertension, obesity, diabetes, and cardiac conditions such as myocardial infarction. Chronic inflammation is a major pathoph...
The chalcone derivative DN-053 attenuates renal fibrosis and inhibits p38 MAPK and STAT3 signaling in renal fibroblasts [0.03%]
茋类衍生物DN-053抗肾纤维化及其对肾成纤维细胞p38和STAT3信号转导的抑制作用
Sudaphon Srichan,Pissared Khuituan,Krittee Dejyong et al.
Sudaphon Srichan et al.
Renal fibrosis is the final common pathway of chronic kidney disease and is largely driven by transforming growth factor-β1 (TGF-β1) signaling. TGF-β1 exerts its cellular effects via two main signaling pathways: the canonical Smad-depend...
Design of sunflower trypsin inhibitor 1 derived probes targeting the LDLR and evaluation of their brain delivery [0.03%]
一种针对LDLR的来源于太阳花胰蛋白酶抑制剂1的衍生物探针的设计及脑靶向递送评价研究
Paula Schwarz,Jonathan Dieringer,Kirtikumar B Jadhav et al.
Paula Schwarz et al.
The blood-brain barrier (BBB) tightly regulates the entry of substances into the CNS (central nervous system). Significant advances in BBB peptide shuttle (BBBpS) research have been achieved in the past; however, the proteolytic instability...
Metal-dependent cell death in doxorubicin-induced cardiotoxicity and mitigation by luteolin: Network pharmacology and experimental verification [0.03%]
网络药理学和实验验证指示芹菜素通过靶向金属离子紊乱改善阿霉素诱发的心脏毒性中的细胞死亡
Amina A Farag,Walaa Bayoumie El Gazzar,Mahmoud Mostafa et al.
Amina A Farag et al.
Doxorubicin (DOX) is a highly effective anthracycline chemotherapeutic agent whose clinical utility is limited by dose-dependent cardiotoxicity. Although oxidative stress and mitochondrial injury are established mechanisms, the contribution...
Iron-quercetin complex induces ex vivo proteomic remodeling in circulating proangiogenic cells derived from human peripheral blood mononuclear cells [0.03%]
铁-芸香苷复合物诱导人外周血单个核细胞来源的循环促血管生成细胞体外蛋白质组重塑
Phakorn Papan,Jiraporn Kantapan,Sucheewin Krobthong et al.
Phakorn Papan et al.
Iron(III)-quercetin complex (IronQ) has previously been shown to support the ex vivo expansion of peripheral blood mononuclear cell (PBMC)-derived proangiogenic cells with CAC-like features, enable MRI-based cell tracking, and enhance proan...
Decellularized tendon scaffold seeded with adipose-derived MSCs and supplemented with G-CSF injection promotes tendon repair in a rat model [0.03%]
脱细胞肌腱支架联合脂肪源性间充质干细胞及G-CSF促进肌腱缺损修复的研究
Hadeer Khaled,Mohammed Zayed,Bumseok Kim et al.
Hadeer Khaled et al.
Background: Tendon injuries cause pain and functional limitations, posing a clinical burden due to poor healing and recurrence. Combining mesenchymal stem cells (MSCs), tissue-specific extracellular matrix (ECM) scaffolds...
Chemical characterization of anti-amyloidogenic phytochemicals from Aconogonon alpinum: Attenuation of cognitive impairment in scopolamine-induced mice [0.03%]
来源于高山升麻的抗淀粉样蛋白生成型植物化学成分的化学特性分析：对丁公藤诱导的小鼠认知障碍的抑制作用
Yeo Eun Kim,Taemin Lee,Hee Ju Kim et al.
Yeo Eun Kim et al.
Neurodegenerative diseases are characterized by abnormal protein aggregation and oxidative stress, which contribute to neuronal damage and cognitive decline. Aconogonon alpinum, known as Shinga in Korea, is a perennial Polygonaceae plant tr...
Enhanced dopamine transporter binding is associated with species-specific 2C-B-induced reinforcement in marmosets, but not in mice [0.03%]
dopa转运体结合增强与狨猴而非小鼠的2C-B诱发欣快感有关
Yong-Qing Zhang,Hyeokjun Kwon,Taeyun Yoo et al.
Yong-Qing Zhang et al.
Hallucinogens have been prescribed for the treatment of mental illnesses; however, reports on the dependence potential of hallucinogens across species remain inconsistent. Non-human primate (NHP) self-administration model are suitable for e...