Amsacrine modifies action potential configuration without its prolongation via the blockade of multiple ion currents in canine ventricular cells
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Amsacrine is an antineoplastic agent for acute lymphoblastic leukemia. It contains methanesulfonamide group -similar to hERG/IKr inhibitors like E-4031 and dofetilide-therefore may exert cardiac arrhythmias. Although amsacrine inhibits expressed hERG channels,... ...
