Therapeutic targeting of folate receptor alpha (FRα) by antibody-polymer-drug conjugate in testicular germ cell tumors [0.03%]
叶酸受体α(FRα)抗体-聚合物-药物偶联物在睾丸生殖细胞肿瘤治疗中的作用研究
Lucia Kučerová,Robert Pola,Marcela Filipová et al.
Lucia Kučerová et al.
Antibody-drug conjugates (ADCs) are an effective treatment for recurrent/refractory testicular germ cell tumors (rrTGCTs). In this exploratory study, we report disease stabilization achieved with the ADC Mirvetuximab soravtansine (MIRV) in ...
Insulin resistance as a driver of neuroinflammation and oxidative stress in Alzheimer's disease: Mechanistic links and therapeutic approaches [0.03%]
胰岛素抵抗在阿尔茨海默病中的作用：驱动神经炎症和氧化应激的机制联系及治疗策略
Parinaz Hajeforoosh,Akbar Hajizadeh Moghaddam,Sedigheh Khanjani Jelodar
Parinaz Hajeforoosh
Alzheimer's disease (AD) is a complex, multifactorial neurodegenerative disorder characterized by the accumulation of amyloid-β plaques and hyperphosphorylated tau protein aggregates, leading to progressive cognitive decline. Growing evide...
Real-time breath metabolomic profiling reveals a volatile signature associated with lung cancer [0.03%]
实时呼吸代谢组学监测发现肺癌相关挥发性标志物
Kai Fricke,Jonas Herth,Diego M Baur et al.
Kai Fricke et al.
Background: Real-time breath metabolomic profiling may detect lung cancer-associated breath features, but exploratory case-control findings require cautious interpretation because small cohorts are susceptible to overfitt...
Therapeutic Salmonella expressing apoptin and CEA elicits combined pro-apoptotic and immune-mediated anticancer effects [0.03%]
表达凋亡素和CEA的治疗性沙门菌产生协同促凋亡和免疫介导的抗肿瘤效应
Jun Kwon,Ram Aganja Prasad,Muhammad Bakhsh et al.
Jun Kwon et al.
In the current study, we genetically engineered Salmonella Typhimurium to serve a dual purpose in cancer immunotherapy, simultaneously inducing apoptosis and activating anti-cancer immune responses. Tumor-residing tryptophan auxotrophic Sal...
Antitrypanosomatid and antiamitochondriate activity of new cyclohexyl-quinoxaline-7-carboxylate-1,4-di-N-oxide derivatives: An in silico and in vitro approach toward the elucidation of their mechanisms of action [0.03%]
新的环己基-喹唑啉-7-甲酸衍生物的抗锥虫和抗线粒体活性：一种通过计算方法和体外方法阐明其作用机制的方法
Alonzo González-González,Lilian Yépez-Mulia,Adriana Moreno-Rodríguez et al.
Alonzo González-González et al.
A new series of cyclohexyl-quinoxaline-7-carboxylate-1,4-di-N-oxide derivatives was synthesized and evaluated in vitro against the trypanosomatids Trypanosoma cruzi and Leishmania mexicana, and the amitochondriates Giardia lamblia, Trichomo...
Mechanistic insights into the immunomodulatory and antibacterial activity of the Japanese Kampo Formula Hainosankyuto [0.03%]
日本汉方制剂海洋三建投的免疫调节和抗菌活性机制研究见解
Manuel Schäffer,Silke Cameron,Keiko Ogawa-Ochiai et al.
Manuel Schäffer et al.
Purpose: This study aimed to quantify the in vitro antibacterial activity of the Japanese herbal formula Hainosankyuto (HNST) against Gram-positive and Gram-negative bacteria and to elucidate its immunomodulatory effects ...
Aspirin hyporesponsiveness in type 2 diabetes mellitus: A systematic review with narrative synthesis of definitions, assessment methods, and clinical relevance [0.03%]
2型糖尿病患者阿司匹林低反应性：定义、评估方法及临床意义的叙述综合系统评价
Laura Ortega-Hombrados,Esther Martín-Aurioles,Ana María Sánchez-Tévar et al.
Laura Ortega-Hombrados et al.
Type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular risk, enhanced platelet activation, and substantial interindividual variability in response to aspirin. However, the term 'aspirin resistance' has been used inconsi...
Corrigendum: "Identification of key genes involved in neural regeneration and the repairing effect of BDNF-overexpressed BMSCs on spinal cord ischemia-reperfusion injury in rats" [Biomed. Pharmacother., 160 (2023) 114293] [0.03%]
勘误：「与神经再生相关的关键基因鉴定及BDNF过表达的骨髓间充质干细胞对大鼠脊髓缺血再灌注损伤修复作用的评估」[Biomed. Pharmacother., 160 (2023) 114293]
Fei Yin,Zhiming Liu,Ding Zhang et al.
Fei Yin et al.
Corrigendum to "Herba Patriniae and its component Isovitexin show anti-colorectal cancer effects by inducing apoptosis and cell-cycle arrest via p53 activation" [Biomed. Pharmacother., 168 (2023) 115690] [0.03%]
“Herba Patriniae及其成分Isovitexin通过激活p53诱导凋亡和细胞周期阻滞显示出抗结直肠癌作用”的勘误 [Biomed. Pharmacother., 168 (2023) 115690]
Jinxiao Li,Luorui Shang,Fangyuan Zhou et al.
Jinxiao Li et al.
A mouse PDX clinical trial reveals broad efficacy of niraparib and vc-seco-DUBA anti-HER2 ADC SYD985 in HER2/neu expressing endometrial cancer [0.03%]
一项小鼠PDX临床试验揭示了尼拉帕利和反式-4-[(1R)-1-环丙基-2,3-二氢-1H-ibenzo[e]indol-1-基]-5-(丙氧基)烟酰胺（vc-seco-DUBA）抗HER2抗体药物偶联物SYD985在表达HER2/neu的子宫内膜癌中的广泛疗效
Cristian Pablo Moiola,Carlos Lopez-Gil,Marta Rebull et al.
Cristian Pablo Moiola et al.
Introduction: Advanced and recurrent high-risk endometrial cancer (EC) frequently develops resistance to platinum-based chemotherapy, leaving patients with limited therapeutic options. Recent studies have shown that HER2 ...