PARP inhibition induces a redox-dependent dormant reservoir vulnerable to disulfiram in high-grade serous ovarian cancer [0.03%]
PARP抑制通过一种依赖于红氧化状态的休眠库诱导剂硫胺敏感的高等级浆液性卵巢癌模型中的活性形式
Sutthipun Suriya,Supawan Jamnongsong,Chanettee Jamyuang et al.
Sutthipun Suriya et al.
Resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) in high-grade serous ovarian cancer (HGSOC) is increasingly driven by non-genetic drug-tolerant dormant cell populations, yet the adaptive programs sustaining these cells remain p...
Preserved motor function and prolonged sensory local anesthesia with novel PLGA microparticles co-encapsulating lidocaine and capsaicin [0.03%]
新型PLGA微球联合封装利多卡因和辣椒素以保留运动功能并延长感觉局部麻醉作用
Asami Ishii,Yuta Aida,Toshiyuki Ikoma et al.
Asami Ishii et al.
Lidocaine (LID) provides rapid local anesthesia but lacks nerve-type selectivity, causing undesired motor impairment, and typically suffers from a rapid washout effect. To address these acute-phase limitations, we developed biodegradable po...
Paclitaxel-loaded nanostructured lipid carriers surface-functionalized with N6L for pancreatic cancer [0.03%]
负载N6L的紫杉醇纳米结构脂质载体用于胰腺癌治疗
Laura Larue,Blandine Brissault,Cléa Chesneau et al.
Laura Larue et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies, with limited therapeutic options. Despite advances in chemotherapy, such as FOLFIRINOX and Abraxane® (nab-paclitaxel) combined with gemcita...
O-GlcNAc transferase as an oncogenic regulator in hematologic malignancies: Mechanisms, disease contexts, and therapeutic perspectives [0.03%]
O-连接-N-乙酰葡萄糖胺转移酶在血液系统恶性肿瘤中的致癌调节作用：机制、疾病背景及治疗前景
Marissa El Hajje,Juan Luiz Coelho-Silva,João Agostinho Machado-Neto et al.
Marissa El Hajje et al.
O-GlcNAc transferase (OGT) catalyzes the addition of N-acetylglucosamine to serine and threonine residues of nuclear and cytoplasmic proteins, coupling cellular metabolic state to the post-translational regulation of hundreds of substrates....
Three-dimensional cell cultures as an in vitro tool for ovarian cancer modeling and natural product discovery [0.03%]
三维细胞培养作为卵巢癌建模和天然药物发现的体外工具
Mirian Carolini Esgoti Aal,Matheus Naia Fioretto,Tainá Dorte da Silva et al.
Mirian Carolini Esgoti Aal et al.
Ovarian cancer (OC) remains the most common cancer among women, with high incidence and mortality rates, prompting extensive investigation across in vivo, in vitro, and clinical settings. In this context, in vitro cell culture models have b...
Amsacrine modifies action potential configuration without its prolongation via the blockade of multiple ion currents in canine ventricular cells [0.03%]
胺硫霉素通过阻断多种离子电流改变动作电位的形态而不延长犬心室肌细胞的动作电位
József Óvári,Zsigmond Máté Kovács,János Magyar et al.
József Óvári et al.
Amsacrine is an antineoplastic agent for acute lymphoblastic leukemia. It contains methanesulfonamide group -similar to hERG/IKr inhibitors like E-4031 and dofetilide-therefore may exert cardiac arrhythmias. Although amsacrine inhibits expr...
Modelling targeted therapy efficacy in NRAS mutant conjunctival melanoma [0.03%]
NRAS突变conjunctival黑色素瘤靶向治疗有效性的建模分析
Eetu Välimäki,Erika Alanne,Janne Suhonen et al.
Eetu Välimäki et al.
Conjunctival melanoma (CoM) is an ultra-rare ocular melanoma that originates from transformed melanocytes of the conjunctiva. CoM shares a common embryonic cell of origin as cutaneous melanoma and manifests as highly aggressive malignancy. ...
Translational consistency of gene therapy strategies targeting inflammation in atrial fibrillation's management [0.03%]
针对房颤管理中靶向炎症的基因治疗策略的转化一致性
Maïssa Zemmouchi,Aseel El-Fermawi,Anya Benagdi et al.
Maïssa Zemmouchi et al.
Atrial fibrillation (AF) is the most common cardiac rhythm disorder. AF risk factors include pathological ageing, hypertension, obesity, diabetes, and cardiac conditions such as myocardial infarction. Chronic inflammation is a major pathoph...
The chalcone derivative DN-053 attenuates renal fibrosis and inhibits p38 MAPK and STAT3 signaling in renal fibroblasts [0.03%]
茋类衍生物DN-053抗肾纤维化及其对肾成纤维细胞p38和STAT3信号转导的抑制作用
Sudaphon Srichan,Pissared Khuituan,Krittee Dejyong et al.
Sudaphon Srichan et al.
Renal fibrosis is the final common pathway of chronic kidney disease and is largely driven by transforming growth factor-β1 (TGF-β1) signaling. TGF-β1 exerts its cellular effects via two main signaling pathways: the canonical Smad-depend...
Design of sunflower trypsin inhibitor 1 derived probes targeting the LDLR and evaluation of their brain delivery [0.03%]
一种针对LDLR的来源于太阳花胰蛋白酶抑制剂1的衍生物探针的设计及脑靶向递送评价研究
Paula Schwarz,Jonathan Dieringer,Kirtikumar B Jadhav et al.
Paula Schwarz et al.
The blood-brain barrier (BBB) tightly regulates the entry of substances into the CNS (central nervous system). Significant advances in BBB peptide shuttle (BBBpS) research have been achieved in the past; however, the proteolytic instability...