Antitrypanosomatid and antiamitochondriate activity of new cyclohexyl-quinoxaline-7-carboxylate-1,4-di-N-oxide derivatives: An in silico and in vitro approach toward the elucidation of their mechanisms of action
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A new series of cyclohexyl-quinoxaline-7-carboxylate-1,4-di-N-oxide derivatives was synthesized and evaluated in vitro against the trypanosomatids Trypanosoma cruzi and Leishmania mexicana, and the amitochondriates Giardia lamblia, Trichomonas vaginalis, and E... ...