Phenotype-driven screening of semi-synthetic terpene analogs identifies TRX-41 as a lead compound active in chemotherapy-resistant breast cancer organoids [0.03%]
基于表型的半合成萜类类似物筛选鉴定出TRX-41可作用于化疗耐药性乳腺癌类器官的先导化合物
Ariela Mo,Gabriel Dos Santos E Silva,Dijovani Batista Dos Reis et al.
Ariela Mo et al.
Natural products remain an important source of anticancer agents, yet identifying pharmacological vulnerabilities in chemotherapy-refractory tumors remains a major challenge. Natural terpenes (NT) represent one of the most structurally dive...
Beyond the full-length toxin: The metalloprotease domain of Pictolysin-III retains key functional properties and cellular activity [0.03%]
超越全长毒素：Pictolysin-III的金属蛋白酶结构域保留了关键的功能特性和细胞活性
Alejandro Roque,Daniel Torrejón,Alex Proleón et al.
Alejandro Roque et al.
Snake venom metalloproteinases are major determinants of viperid venom pathology, but the specific contribution of their metalloprotease domain to toxin function remains insufficiently defined. Here, we produced and characterized the metall...
From gut-derived metabolites to topical targets: 5-(3',4'-dihydroxyphenyl)-γ-valerolactone as an anti-inflammatory candidate for skin and mucosal inflammation [0.03%]
从肠道来源的代谢物到局部治疗靶点：5-(3',4'-二羟基苯基)-γ- valerolactone作为皮肤和黏膜炎症的抗炎候选药物
Weronika Skowrońska,Rafał M Kiełkiewicz,Maja Kirzyc et al.
Weronika Skowrońska et al.
Plant-derived compounds can be transformed by the human gut microbiota into postbiotic metabolites with distinct structures and biological activities, providing insight into the mechanisms underlying the pharmacological effects of medicinal...
MHY5535, a novel PPARα antagonist, sensitizes ovarian cancer stem cells to chemotherapy by disrupting fatty acid oxidation-dependent mitochondrial metabolism [0.03%]
新型PPARα拮抗剂MHY5535通过破坏脂肪酸氧化依赖的线粒体代谢增强卵巢癌干细胞对化疗的敏感性
Min Joo Shin,Sang Gyun Noh,Seo Yul Lee et al.
Min Joo Shin et al.
Ovarian cancer stem cells (CSCs) drive chemoresistance and tumor relapse through metabolic adaptability and enhanced mitochondrial function. Emerging evidence implicates peroxisome proliferator-activated receptor α (PPARα) as a critical r...
Proof-of-concept study in patient-derived organoids from malignant pleural effusion for functional testing in thoracic tumors [0.03%]
胸腔肿瘤功能检测的恶性胸腔积液患者衍生类器官的概念验证研究
Rocio Ferreiro-Miguens,Isabel Diez-Grandio,Roi Soto et al.
Rocio Ferreiro-Miguens et al.
Thoracic malignancies, including lung adenocarcinoma and malignant pleural mesothelioma, remain associated with poor prognosis and limited durable responses in advanced stages. Although targeted therapies and immunotherapy have improved out...
Engineered PEA-producing Lactobacillus paracasei F19 prevents colitis-associated colorectal cancer in mice by modulating inflammatory-angiogenic signaling and beneficially reshapes gut microbiota composition [0.03%]
工程化产生PEA的乳酸菌F19通过调节炎性血管生成信号预防小鼠结肠炎相关结直肠癌并重塑肠道微生物群组成
Irene Palenca,Walter Sanseverino,Roberto Malinverni et al.
Irene Palenca et al.
Colitis-associated colorectal cancer (CAC) arises from the interplay between chronic inflammation, epithelial dysregulation, angiogenesis, and microbiota alterations. Palmitoylethanolamide (PEA) is an endogenous lipid mediator with anti-inf...
Microglial immunometabolism in Alzheimer's disease: A stage-resolved trajectory from adaptive remodeling to the metabolic paradox [0.03%]
阿尔茨海默病中小胶质细胞免疫代谢：从适应性重塑到代谢悖论的阶段化解析轨迹
Yue Zou,Yi Ou,Hang Zhao et al.
Yue Zou et al.
Microglia are central regulators of the cellular phase of Alzheimer's disease (AD). Under chronic exposure to amyloid-β, pathological tau, and aging-associated bioenergetic decline, these cells undergo immunometabolic remodeling that may i...
Mitochondrial bioenergetic remodeling underlies fingolimod-induced immunometabolic adaptation in multiple sclerosis [0.03%]
芬戈莫德通过线粒体生物能重塑诱导多发性硬化免疫代谢重编程
Adela González-Jiménez,Pilar López-Cotarelo,Alba Moreno-Jerez et al.
Adela González-Jiménez et al.
Mitochondrial dysfunction and immune cell metabolic reprogramming are central mechanisms driving the pathogenesis and progression of multiple sclerosis (MS). Fingolimod (FTY720), a sphingosine-1-phosphate analog widely used in MS, limits ly...
Irreversible cell electroporation-induced release of DAMPs increases cancer cell resistance to electroporation [0.03%]
不可逆细胞电穿孔诱导的DAMPs释放可增加癌细胞对电穿孔的抗性
B Jakštys,S Vykertas,R Palepšienė et al.
B Jakštys et al.
Irreversible electroporation (IRE) utilizes high-voltage pulses to permeabilize cell membranes and induce cancer cell death, a process that releases damage-associated molecular patterns (DAMPs) and triggers immune responses. This study inve...
Tetracyclic triterpenes from Chios Mastic Gum act as TGR5 and RORγ modulators [0.03%]
土耳其奇奥斯乳香树皮中四环三萜类化合物作为TGR5和RORγ调节剂的作用
Alexander F Perhal,Lorenza Bertaina,Jorge Enrique Hernández González et al.
Alexander F Perhal et al.
Background: Chios mastic gum (CMG) is a natural resin from Pistacia lentiscus L. var. Chia (Anacardiaceae). It contains high concentrations of triterpenoids, with 24Z-masticadienonic acid (24Z-MNA) and 24Z-isomasticadieno...