Mechanistic insights into the immunomodulatory and antibacterial activity of the Japanese Kampo Formula Hainosankyuto [0.03%]
日本汉方制剂海洋三建投的免疫调节和抗菌活性机制研究见解
Manuel Schäffer,Silke Cameron,Keiko Ogawa-Ochiai et al.
Manuel Schäffer et al.
Purpose: This study aimed to quantify the in vitro antibacterial activity of the Japanese herbal formula Hainosankyuto (HNST) against Gram-positive and Gram-negative bacteria and to elucidate its immunomodulatory effects ...
Aspirin hyporesponsiveness in type 2 diabetes mellitus: A systematic review with narrative synthesis of definitions, assessment methods, and clinical relevance [0.03%]
2型糖尿病患者阿司匹林低反应性：定义、评估方法及临床意义的叙述综合系统评价
Laura Ortega-Hombrados,Esther Martín-Aurioles,Ana María Sánchez-Tévar et al.
Laura Ortega-Hombrados et al.
Type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular risk, enhanced platelet activation, and substantial interindividual variability in response to aspirin. However, the term 'aspirin resistance' has been used inconsi...
Corrigendum: "Identification of key genes involved in neural regeneration and the repairing effect of BDNF-overexpressed BMSCs on spinal cord ischemia-reperfusion injury in rats" [Biomed. Pharmacother., 160 (2023) 114293] [0.03%]
勘误：「与神经再生相关的关键基因鉴定及BDNF过表达的骨髓间充质干细胞对大鼠脊髓缺血再灌注损伤修复作用的评估」[Biomed. Pharmacother., 160 (2023) 114293]
Fei Yin,Zhiming Liu,Ding Zhang et al.
Fei Yin et al.
Corrigendum to "Herba Patriniae and its component Isovitexin show anti-colorectal cancer effects by inducing apoptosis and cell-cycle arrest via p53 activation" [Biomed. Pharmacother., 168 (2023) 115690] [0.03%]
“Herba Patriniae及其成分Isovitexin通过激活p53诱导凋亡和细胞周期阻滞显示出抗结直肠癌作用”的勘误 [Biomed. Pharmacother., 168 (2023) 115690]
Jinxiao Li,Luorui Shang,Fangyuan Zhou et al.
Jinxiao Li et al.
A mouse PDX clinical trial reveals broad efficacy of niraparib and vc-seco-DUBA anti-HER2 ADC SYD985 in HER2/neu expressing endometrial cancer [0.03%]
一项小鼠PDX临床试验揭示了尼拉帕利和反式-4-[(1R)-1-环丙基-2,3-二氢-1H-ibenzo[e]indol-1-基]-5-(丙氧基)烟酰胺（vc-seco-DUBA）抗HER2抗体药物偶联物SYD985在表达HER2/neu的子宫内膜癌中的广泛疗效
Cristian Pablo Moiola,Carlos Lopez-Gil,Marta Rebull et al.
Cristian Pablo Moiola et al.
Introduction: Advanced and recurrent high-risk endometrial cancer (EC) frequently develops resistance to platinum-based chemotherapy, leaving patients with limited therapeutic options. Recent studies have shown that HER2 ...
Trametinib-mediated MEK inhibition impairs cancer cell viability and invasion in patient-derived tumor avatars of glioblastoma with extraneural metastases: A proof-of-concept study [0.03%]
曲马替尼介导的MEK抑制作用损害了胶质母细胞瘤伴颅外转移患者衍生肿瘤模型中癌细胞的存活和侵袭：一项概念验证研究
Metka Novak,Bernarda Majc,Marija Skoblar Vidmar et al.
Metka Novak et al.
Glioblastoma (GBM) remains one of the most lethal human malignancies, yet extraneural metastases are exceptionally rare and poorly understood. Standard treatment-surgical resection followed by chemoradiotherapy-offers only modest survival b...
Highly potent antiviral drug candidates targeting SARS-CoV-2 nsp3 and nsp5 [0.03%]
靶向SARS-CoV-2 nsp3和nsp5的高效抗病毒药物候选物
Mathilde Galais,Guillaume Herlem,Sandy Haidar Ahmad et al.
Mathilde Galais et al.
Faced with the repeated emergence of three major epidemics caused by coronaviruses over the past 20 years (SARS-CoV in 2002, MERS-CoV in 2012, and SARS-CoV-2 in 2019), the development of novel antiviral treatments has become a critical publ...
The estrogen-integrin αvβ3 crosstalk in breast cancer: Modulating PD-L1 and immune evasion [0.03%]
乳腺癌中雌激素与整合素αvβ3的相互作用：调节PD-L1和免疫逃逸
Dana R Crawford,Yung-Ning Yang,Feng-Cheng Liu et al.
Dana R Crawford et al.
The mechanisms governing PD-L1 expression in breast cancer are highly complex and context-dependent. This article proposes a novel "dual-track" regulatory model to resolve the conflicting roles of estrogen in tumor immunity. Genomic signali...
Intravenous immunoglobulin recalibrates monocyte responses to abortive SARS-CoV-2 infection across viral variants [0.03%]
静脉用免疫球蛋白可校正败血症型新冠病毒感染的单核细胞反应（涵盖各种病毒谱系）
Meryem Alaka,Benoit Desnues
Meryem Alaka
Monocytes contribute to inflammation during coronavirus disease 2019 (COVID-19), yet their capacity to support productive infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the impact of viral evolution on their ...
Corrigendum "Intra-abdominal transplantation of PLGA/PCL/M13 phage electrospun scaffold induces self-assembly of lymphoid tissue-like structure" [Biomed. Pharmacother. 173 (2024) 116382] [0.03%]
“PLGA/PCL/M13噬菌体电纺支架的腹腔内移植诱导类似淋巴组织结构自组装”的勘误[Biomed. Pharmacother. 173 (2024) 116382]
Zohreh Safari,Majid Sadeghizadeh,Ahmad Zavaran Hosseini et al.
Zohreh Safari et al.