Galectin-3 as a therapeutic target in pulmonary hypertension: Molecular mechanisms, drug development directions, and emerging clinical applications [0.03%]
半乳糖凝集素3在肺动脉高压治疗中的作用机制、药物研发方向及临床应用展望
Antonín Sedlář,Pavla Bojarová,František Kolář et al.
Antonín Sedlář et al.
Pulmonary hypertension (PH) remains a devastating cardiovascular disorder with limited targeted treatment. Galectin-3 has emerged as a promising therapeutic target due to its central role in vascular remodeling and inflammation. Galectin-3 ...
Novel targets for treating cancer and inflammatory disorders: A disintegrin-metalloprotease-10 and cyclooxygenase-2 feedback loop modulated by Aconitum heterophyllum leaf biomarkers with computational biology [0.03%]
计算生物学引导的皇冠草叶活性成分通过新型抗炎抗癌靶点ADAM-10和COX-2反馈回路的作用机制研究
Muhammad Ilyas,Anwar Ali Shad,Aiman Orakzai et al.
Muhammad Ilyas et al.
Background: Since antiquity, humans have relied on diverse natural products species for disease treatment and health enhancement. Aconitum is comprised of pharmacologically active biomarkers and offers a tempting prospect...
Endogenous gut microbiome and implanted intranasal E. coli-Nissle modulate cancer tissues metabolism in 4T1 syngeneic tumor bearing mice [0.03%]
肠道菌群和鼻内植入的E.coli-Nissle对4T1同基因肿瘤小鼠体内癌组织代谢的调节作用研究
Alexander Cecil,Ivaylo Gentschev,Cornelia Prehn et al.
Alexander Cecil et al.
Despite recent progress in the diagnosis and treatment of advanced cancers, the overall patient treatment outcome did not substantially improve over the last years. Therefore, developing novel therapies, which may also work synergistically ...
Epidural pre-formed long-acting implants as a novel and challenging approach for brain drug delivery [0.03%]
独特的脑内给药方式经硬膜外途径预置长效缓释剂的研究挑战与机遇
O Hyun Lee,Ji Hee Kang,Da Hee Oh et al.
O Hyun Lee et al.
Antipsychotic drugs often fail to reach therapeutic levels in the brain because the blood-brain barrier limits penetration, making safe, effective treatment difficult. We engineered a solvent-free, pre-formed long-acting implant based on po...
Increases in brain catecholamine levels counteract memory deficits and reduces Aβ deposition in 5XFAD male mice [0.03%]
脑内儿茶酚胺水平升高可改善5XFAD雄性小鼠的学习记忆缺损并降低其Aβ沉积水平
Eunbi Cho,Jee Hyun Yi,Se Jin Jeon et al.
Eunbi Cho et al.
Alzheimer's disease (AD) is a degenerative brain disease that presents with neurological symptoms and memory loss, with no clear treatment. Catecholamines, including dopamine, epinephrine, and norepinephrine, can inhibit or degrade the abno...
Mitochondrial cargo quality determines the paracrine effects of extracellular vesicles derived from vascular endothelial cells [0.03%]
线粒体货物质量决定了血管内皮细胞衍生的细胞外囊泡的旁分泌效应
Zahid A Manzar,Lucas J Davis,Karl F Swanson et al.
Zahid A Manzar et al.
Cell-derived extracellular vesicles (EV) are mediators of intercellular communication with increased circulating levels of endothelial cell-derived EV (EC-EV) reported in cardiovascular diseases (CVD). The EC-EV ability to elicit either det...
Vutiglabridin ameliorates obesity by directly reducing fat mass through AMPK/lipophagy activation in adipocytes [0.03%]
肉桂素通过激活脂肪细胞中的AMPK／脂质自噬直接减少脂肪质量从而改善肥胖
Hyeong Min Lee,Jae Ho Lee,Sang Hyo Kim et al.
Hyeong Min Lee et al.
Current anti-obesity therapies that suppress appetite often cause undesirable reductions in lean mass by indirectly depleting systemic energy store. In this study, we developed a novel anti-obesity drug, Vutiglabridin (VUTI), designed to se...
Role of JNK3 signaling in acute ischemic stroke cerebroprotection: A systematic review [0.03%]
JNK3信号在急性缺血性卒中脑保护中的作用：系统评价
Federica Ferrari,Federico Mazzacane,Beatrice Del Bello et al.
Federica Ferrari et al.
Ischemic stroke lacks clinically proven cerebroprotectants, partly because candidate targets have not been evaluated with rigorous translational pipelines. The aim of this study was to perform a systematic review about the potential role of...
Combination of CBD with minor cannabinoid CBDV suppresses CXCR4 via CB2 receptor and alleviates colitis in mice [0.03%]
cannabidiol与次要大麻素CBDV联合通过CB2受体抑制CXCR4并缓解小鼠结肠炎
Anat Gelfand,Elazar Besser,Shiri Procaccia et al.
Anat Gelfand et al.
Cannabis extracts, particularly those rich in cannabinoids like cannabidiol (CBD), have shown potential anti-inflammatory properties and are being examined in managing conditions involving inflammation. One proposed mechanism is their modul...
Effects of isoflurane on tetrodotoxin-resistant Na⁺ channels in rat nociceptive sensory neurons: Roles of concentration and extracellular pH [0.03%]
异氟醚对大鼠痛觉感觉神经元中四氯酚耐药的钠通道的影响：浓度和细胞外PH值的作用
Michiko Nakamura,Il-Sung Jang
Michiko Nakamura
Isoflurane is widely employed to induce unconsciousness, amnesia, immobility, and analgesia in general anesthesia. Voltage-gated Na+ channels are one of the molecular targets for volatile anesthetics; however, knowledge regarding how isoflu...