TTP enhances the sensitivity of KRASG12C-mutated lung cancer cells to KRASG12C inhibitors by downregulating SLC7A11 and promoting ferroptosis [0.03%]
TTP通过下调SLC7A11并促进铁死亡来增强KRASG12C突变肺癌细胞对KRASG12C抑制剂的敏感性
Ki Ra Park,Minh-Xuan Le,Ok Joo Sul et al.
Ki Ra Park et al.
Covalent KRASG12C inhibitors are used to treat patients with KRASG12C-mutated non-small cell lung cancer (NSCLC). However, many patients do not respond to therapy due to intrinsic or acquired resistance. The mechanisms underlying resistance...
Bixin prevents tubulointerstitial fibrosis in hyperuricemic nephropathy via promoting PPARγ-NLRP3 interaction [0.03%]
白藜芦醇通过促进PPARγ-NLRP3相互作用防治高尿酸血症肾损害的管间质纤维化
Yun Cao,Jie Deng,Mingying Lin et al.
Yun Cao et al.
Hyperuricemic nephropathy (HN), characterized by severe inflammation-induced tubulointerstitial fibrosis (TIF), has emerged as a common subtype of chronic kidney disease. Bixin, a carotenoid extracted from the seeds of Bixa orellana, recent...
Corrigendum to "Gene and drug-mediated SERCA2a activation restores cardiac function and metabolic balance in diabetic mice" [Biomed. Pharmacother. 192, November 2025, 118617] [0.03%]
糖尿病小鼠心脏功能和代谢平衡的基因和药物介导的SERCA2a激活恢复的勘误表[Biomed. Pharmacother. 192, 2023年11月, 118617]
Soojeong Kang,Abdul Majid,Nadjib Hammoudi et al.
Soojeong Kang et al.
A phenotype-driven data and drug repurposing strategy used to identify potential treatments targeting chondrocyte hypertrophy in osteoarthritis [0.03%]
一种基于表型的再利用数据和药物策略，用于识别针对骨关节炎中软骨细胞肥大靶点的潜在治疗方法
Judith Veldman,Mauricio N Ferrao Blanco,Nicole Kops et al.
Judith Veldman et al.
Osteoarthritis (OA) is a common disabling disease for which no effective pharmacological therapy exists. The progression of osteoarthritis is characterized by the loss of homeostasis in the cartilage. Since in the early stages of the diseas...
Exploring the impact of metformin on the central nervous system and neurotransmission: A systematic review [0.03%]
二甲双胍对中枢神经系统和神经传导影响的系统评价
Aleksandra Maciejczyk,Kamilla Blecharz-Klin
Aleksandra Maciejczyk
Background: Metformin, a well-established antidiabetic agent, has emerging neuroactive properties extending beyond glycemic control. Evidence suggests effects on neurotransmission, neuroprotection, and neuroinflammatory p...
Evaluation of antidepressant and sleep-promoting effects of cordycepin in a menopause-like stress model [0.03%]
评估虫草素在类似绝经压力模型中的抗抑郁和促睡眠作用评价虫草素在类更年期应激模型中的抗抑郁和助眠效应
Min Sook Ye,Su-Chan Lee,Si-Kwan Kim et al.
Min Sook Ye et al.
The menopausal transition is often accompanied by mood disturbances and sleep disorders, exacerbated by estrogen deficiency and chronic stress. Although hormone replacement therapy (HRT) is effective, its use is limited by safety concerns, ...
Fish-derived lipids directly stimulate NK cell activity and IFN-γ synthesis: A novel dietary intervention strategy to enhance antiviral immunity in humans [0.03%]
鱼衍生脂质直接刺激NK细胞活性和IFN-γ合成：一种增强人体抗病毒免疫力的新饮食干预策略
Magdalena Namiecińska,Mirella Stańdo-Retecka,Pawel Piatek et al.
Magdalena Namiecińska et al.
Viral infections are a leading cause of morbidity and mortality worldwide. Clinical studies suggest that a diet rich in marine fatty acids present in fish-derived oil (FDO) may improve antiviral immunity. However, there is limited evidence ...
Exploring and bypassing resistance to targeted therapies in colorectal cancer [0.03%]
结直肠癌靶向治疗的耐药性探索与克服
Solène Favier,Wei Xiong,Mounira Chalabi-Dchar et al.
Solène Favier et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related deaths globally, though targeted therapies have transformed treatment and brought renewed hope. However, resistance to these therapies is a persistent challenge, driven by ge...
Metabolic stress-response in female rats: β-oxidation-induced vulnerability vs adaptive resilience [0.03%]
雌性大鼠代谢压力反应：β氧化诱导的脆弱性与适应性耐受力
Paola Brivio,Silvia Pedretti,Maria Teresa Gallo et al.
Paola Brivio et al.
Major depressive disorder (MDD) is characterized by substantial sex differences in its prevalence, with women having double the risk to experience MDD compared to men. One of the major goals of research is to understand the sex-specific fac...
Joohyun Lee,Jiye Kim,Inah Hwang
Joohyun Lee
Arginine methylation is increasingly recognized as a key regulatory mechanism in cancer, exerting broad influence over chromatin organization, RNA metabolism, and oncogenic signaling. Protein arginine methyltransferase 5 (PRMT5) catalyzes s...