Carboxylated mesoporous silica nanoparticle-nucleic acid chimera conjugate-assisted delivery of siRNA and doxorubicin effectively treat drug-resistant bladder cancer [0.03%]
羧基化介孔二氧化硅纳米粒子-核酸嵌合子共轭物介导siRNA和阿霉素协同治疗耐药性膀胱癌
Jintao Yang,Biao Liu,Qi Wang et al.
Jintao Yang et al.
Chemotherapy is the main treatment for bladder cancer, but drug resistance and side effects limit its application and therapeutic effect. Herein, we constructed doxorubicin (DOX)/COOH-mesoporous silica nanoparticle/polyethylenimine (PEI)/nu...
Focus on cuproptosis: Exploring new mechanisms and therapeutic application prospects of cuproptosis regulation [0.03%]
聚焦铜死亡：铜死亡调控新机制及转化应用前景探索
Donglin Hao,Wei Luo,Yongmin Yan et al.
Donglin Hao et al.
Cuproptosis is a novel form of regulated cell death, which plays an important role in the physiological and pathological processes of the human body. Despite the increasing research on cuproptosis-related genes (CRGs) and their correlation ...
Isoliquiritigenin alleviates experimental autoimmune encephalomyelitis by modulating inflammatory and neuroprotective reactive astrocytes [0.03%]
isoliquiritigenin通过调节炎症性和神经保护性星形胶质细胞缓解实验性自身免疫性脑脊髓炎
Ya-Ling Zhang,Yuan Qu,Huan-Huan Song et al.
Ya-Ling Zhang et al.
Multiple sclerosis (MS) is an autoimmune-mediated chronic inflammatory demyelinating disease of the central nervous system (CNS) that poses significant treatment challenges. Currently, it is believed that inflammatory and neuroprotective re...
Therapeutic effect of nicotinamide mononucleotide on Alzheimer's disease through activating autophagy and anti-oxidative stress [0.03%]
烟酰胺单核苷酸通过激活自噬和抗氧化应激改善阿尔茨海默病的治疗作用
Rui-Yin Ma,Li Li,Hui Yang et al.
Rui-Yin Ma et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of β-amyloid (Aβ) plaques and neurofibrillary tangles composed of tau protein in the brain. These neuropathological hallmarks contribute to cognitive...
Interactions of bosutinib with drug transporters: In vitro and In vivo inhibition of organic cation transporter 2, multidrug and toxin extrusion protein 1, and breast cancer resistance protein by bosutinib [0.03%]
博苏替尼与药物转运蛋白的相互作用：博苏替尼对有机阳离子转运蛋白2、多药和毒素外排蛋白1以及乳腺癌耐药蛋白的体外和体内抑制作用
Min-Ji Kang,Min Ju Kim,Yunjin Seol et al.
Min-Ji Kang et al.
Bosutinib has been approved for use in patients with chronic myeloid leukemia. Information regarding the effects of bosutinib on clinically important drug transporters is limited, particularly regarding its inhibitory potency on transporter...
Xin Zhao,Qingxuan Zeng,Siting Yu et al.
Xin Zhao et al.
GLP-1 receptor agonists (GLP-1RAs) are an innovative class of drugs with significant therapeutic value for type 2 diabetes mellitus (T2DM). The GLP-1RAs currently available on the market are biologic macromolecular peptide agents that are e...
The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds [0.03%]
细胞因子、炎症和抗氧化物之间的相互作用：各种抗氧化物和抗细胞因子化合物的机制见解及治疗潜力
Nitish Kumar Bhol,Madhabi Madhusmita Bhanjadeo,Anup Kumar Singh et al.
Nitish Kumar Bhol et al.
Cytokines regulate immune responses essential for maintaining immune homeostasis, as deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory disorders. The antioxidants emerge as promising therapeutic agents ...
Posttranslational modifications of E2F family members in the physiological state and in cancer: Roles, mechanisms and therapeutic targets [0.03%]
E2F家族成员在生理和癌症状态下的转录后修饰：作用、机制及治疗靶点
Mingyang Sun,Yitong Ji,Guojun Zhang et al.
Mingyang Sun et al.
The E2F transcription factor family, whose members are encoded by the E2F1-E2F8 genes, plays pivotal roles in the cell cycle, apoptosis, metabolism, stemness, metastasis, aging, angiogenesis, tumor promotion or suppression, and other biolog...
oHSV2-mGM repolarizes TAMs and cooperates with αPD1 to reprogram the immune microenvironment of residual cancer after radiofrequency ablation [0.03%]
经射频消融治疗后的残余肿瘤中oHSV2-mGM重新极化TAM并与αPD1协同作用，以重编程免疫微环境
Licheng Zhu,Jia Huang,Siqi Zhang et al.
Licheng Zhu et al.
Background: Due to the size and location of the tumor, incomplete radiofrequency ablation (iRFA) of the target tumor inhibits tumor immunity. In this study, a murine herpes simplex virus (oHSV2-mGM) armed with granulocyte...
Phosphatidylserine improves aging sepsis survival, modulates gut microbiome, and prevents sepsis-associated encephalopathy [0.03%]
磷脂酰丝氨酸改善脓毒症的存活率，并预防与脓毒症相关的脑病及调节肠道微生物群
Kejia Xu,Qiong Huang,Ying Lyu et al.
Kejia Xu et al.
Aged adults are prone to both short- and long-term complications following sepsis due to ineffective therapy. Phosphatidylserine (PS) is a membrane nutrient supplement known to enhance cognition and brain function, but its potential effects...