Elevation of the mechanically-sensitive e protein emerin links nuclear mechanotransduction to tau-induced cytoskeletal remodeling in neurons [0.03%]
机械敏感性E蛋白emerin的活化连接了核力学信号转导与tau诱导的神经元细胞骨架重塑
Claira Sohn,Sammy Pardo,Dana Molleur et al.
Claira Sohn et al.
Neurodegenerative tauopathies, including Alzheimer's disease, are neuropathologically defined by pathological tau deposition. While tau drives neurotoxicity by disrupting cytoskeletal, nucleoskeletal, and genomic architecture, cellular mech...
Nuclear mechanotransduction: tools for mechanical perturbation and chromatin characterization [0.03%]
核机械信号转导：用于机械刺激和染色质表征的工具
Jennifer Soto,Nolan Origer,Yifan Wu et al.
Jennifer Soto et al.
Mechanical cues, ranging from matrix mechanical properties to dynamic mechanical loading, can be transmitted via structural proteins and signaling molecules to the nucleus to reorganize nuclear architecture and modulate chromatin accessibil...
Osman Esen,Edmund Battey,Matthew J Stroud et al.
Osman Esen et al.
Aging leads to a progressive loss of muscle mass and strength, termed sarcopenia, which is accelerated by inactivity and exacerbated by intrinsic cellular and molecular dysfunctions within the muscle fiber. Central to these changes is mecha...
Intrinsically disordered regions facilitate Mlp1-Nab2 recognition in mRNA quality control [0.03%]
固有无序区城可促进mRNA质量检测中Mlp1-Nab2的识别作用
Mohammad Soheilypour,Mohaddeseh Peyro,Hengameh Shams et al.
Mohammad Soheilypour et al.
Quality control of mRNAs ensures that only properly processed transcripts are exported from the nucleus. Myosin-like protein 1 (Mlp1), plays a central role in this process by interacting with RNA-binding proteins (RBPs), including Nab2. Whi...
Zanetta Kechagia,Ohad Medalia
Zanetta Kechagia
The nucleus is a structurally diverse and dynamic organelle that anchors chromatin and orchestrates a large number of essential processes, including transcription, replication, ribosome biogenesis, and nucleocytoplasmic transport. Understan...
Nuclei on the move: LINC complex-dependent and -independent mechanisms of nuclear migration in development [0.03%]
动态细胞核：发育中LINC复合物依赖和非依赖的细胞核迁移机制
Selin Gümüşderelioğlu,G W Gant Luxton,Daniel A Starr
Selin Gümüşderelioğlu
Nuclear positioning drives developmental processes from fertilization to neurogenesis. The linker of nucleoskeleton and cytoskeleton (LINC) complex connects nuclei to cytoskeletal force generators that power nuclear migration. Mutations in ...
Integration of nuclear mechanosensing with integrin-extracellular matrix adhesions [0.03%]
整合核机械感受与整合素-细胞外基质粘附之间的联系
Sandra Sandria,Megan C King
Sandra Sandria
Defining the role mechanical forces play in determining cell identity and function is imperative to interpreting cellular and physiological phenomena, as well as inspiring the development of novel therapeutics. As the field of mechanotransd...
Antagonistic contributions of A-type and B-type lamins to LBR localization and dynamics [0.03%]
A型和B型纤丝蛋白拮抗调节LBR定位和动态属性的贡献
Jacob Odell,Kristen Nedza,Alexander Sopilniak-Mints et al.
Jacob Odell et al.
Lamin B receptor (LBR) is an inner nuclear membrane protein that organizes peripheral heterochromatin and cooperates with lamins to tether chromatin at the nuclear periphery. However, how individual lamin isoforms regulate LBR localization ...
Olivetol induces a non-genotoxic nucleolar DNA damage response via membrane-dependent stress signaling [0.03%]
橄榄酸通过膜依赖性应激信号诱导非基因毒性核仁DNA损伤反应
Dmitry A Deriglazov,Nadezhda V Petrova,Artem V Luzhin et al.
Dmitry A Deriglazov et al.
Olivetol (5-pentylresorcinol) is a naturally occurring alkylresorcinol whose cellular mechanism remains poorly understood. Here, we show that olivetol induces a non-genotoxic nucleolar DNA damage response (n-DDR) in human cells. Although mo...
Repair of single-strand breaks during the cell cycle - saturation of repair capacity [0.03%]
细胞周期中单链断裂的修复作用-修复能力达到饱和状态
Oskar Szelest,Agnieszka Hoang-Bujnowicz,Jurek W Dobrucki et al.
Oskar Szelest et al.
Imaging of recruitment of XRCC1 and PCNA to a predetermined number of DNA single-strand breaks (SSB) demonstrates that (i) short-patch base excision repair is active throughout the whole cell cycle and repairs SSBs in over 60% of nonreplica...