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More than SAM: mechanisms of action of the Polycomb group protein polyhomeotic

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The Polycomb Group (PcG) system controls developmental transitions and cell states across species. Two main PcG complexes, Polycomb Repressive Complexes 1 and 2 (PRC1, PRC2), regulate transcription and form epigenetic memory through chromatin. Polyhomeotic (Ph... ...