Vitamin D influences gut microbiota and acetate production in zebrafish (Danio rerio) to promote intestinal immunity against invading pathogens [0.03%]
维生素D通过影响斑马鱼（Danio rerio）肠道微生物群和乙酸盐的产生来促进肠道免疫以对抗入侵病原体
Xinmeng Liao,Yawen Lan,Wentao Wang et al.
Xinmeng Liao et al.
Although evidence has shown that vitamin D (VD) influences gut homeostasis, limited knowledge is available how VD regulates intestinal immunity against bacterial infection. In the present study, cyp2r1 mutant zebrafish, lacking the capacity...
Cecum axis (CecAx) preservation reveals physiological and pathological gradients in mouse gastrointestinal epithelium [0.03%]
Cecum轴（CecAx）的保存揭示了小鼠胃肠上皮组织的生理和病理梯度
Hannah M Lunnemann,Nicolas G Shealy,Michelle L Reyzer et al.
Hannah M Lunnemann et al.
The mouse cecum has emerged as a model system for studying microbe-host interactions, immunoregulatory functions of the microbiome, and metabolic contributions of gut bacteria. Too often, the cecum is falsely considered as a uniform organ w...
Cholestasis: exploring the triangular relationship of gut microbiota-bile acid-cholestasis and the potential probiotic strategies [0.03%]
胆汁淤积：探索肠道菌群-胆汁酸-胆汁淤积的三角关系及潜在益生菌策略
Leilei Yu,Yaru Liu,Shunhe Wang et al.
Leilei Yu et al.
Cholestasis is a condition characterized by the abnormal production or excretion of bile, and it can be induced by a variety of causes, the factors of which are extremely complex. Although great progress has been made in understanding chole...
Secreted Aeromonas GlcNAc binding protein GbpA stimulates epithelial cell proliferation in the zebrafish intestine [0.03%]
豚鼠气单胞菌分泌的GbpA蛋白通过结合粘膜上皮细胞甘露糖受体刺激肠道上皮细胞增殖
Allison V Banse,Stephanie VanBeuge,T Jarrod Smith et al.
Allison V Banse et al.
In response to microbiota colonization, the intestinal epithelia of many animals exhibit increased rates of cell proliferation. We used gnotobiotic larval zebrafish to identify a secreted factor from the mutualist Aeromonas veronii that is ...
Effect of food additives on key bacterial taxa and the mucosa-associated microbiota in Crohn's disease. The ENIGMA study [0.03%]
食物添加剂对克罗恩病关键细菌类群和粘膜相关微生物组的影响——ENIGMA研究
J J Jimenez Loayza,S Kang,L Schooth et al.
J J Jimenez Loayza et al.
Food additives have been linked to the pro-inflammatory microbial dysbiosis associated with Crohn's disease (CD) but the underlying ecological dynamics are unknown. Here, we examine how selection of food additives affects the growth of mult...
Cholestasis impairs gut microbiota development and bile salt hydrolase activity in preterm neonates [0.03%]
胆汁淤积通过影响早产儿肠道菌群发育和胆盐水解酶活性来削弱其生理功能
Lauren E Lynch,Amy B Hair,Krishnakant G Soni et al.
Lauren E Lynch et al.
Cholestasis refers to impaired bile flow from the liver to the intestine. In neonates, cholestasis causes poor growth and may progress to liver failure and death. Normal bile flow requires an intact liver-gut-microbiome axis, whereby liver-...
Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut [0.03%]
雄性小鼠肠道中类固醇分解的肠道细菌对循环雄激素的调节作用
Tsun-Hsien Hsiao,Chia-Hong Chou,Yi-Lung Chen et al.
Tsun-Hsien Hsiao et al.
Abnormally high circulating androgen levels have been considered a causative factor for benign prostatic hypertrophy and prostate cancer in men. Recent animal studies on gut microbiome suggested that gut bacteria are involved in sex steroid...
Alberto Caminero,Mabel Guzman,Josie Libertucci et al.
Alberto Caminero et al.
Proteases are an evolutionarily conserved family of enzymes that degrade peptide bonds and have been implicated in several common gastrointestinal (GI) diseases. Although luminal proteolytic activity is important for maintenance of homeosta...
Jonathan A Chapman,Christopher J Stewart
Jonathan A Chapman
Following microbial colonization at birth, the gut microbiome plays a vital role in the healthy development of human neonates and impacts both health and disease in later life. Understanding the development of the neonatal gut microbiome an...
Intestinal group 1 innate lymphoid cells drive macrophage-induced inflammation and endocrine defects in obesity and promote insulinemia [0.03%]
肠固有层中的innate淋巴细胞群1通过巨噬细胞介导的炎症和内分泌异常在肥胖中促进高胰岛素血症
Rebeca Liébana-García,Marta Olivares,Carlos Francés-Cuesta et al.
Rebeca Liébana-García et al.
Hypercaloric diets overactivate the intestinal immune system and disrupt the microbiome and epithelial cell functions, impairing glucose metabolism. The origins of this inflammatory cascade are poorly characterized. We investigated the invo...