Early-life gut dysbiosis programs divergent metabolic trajectories in a sex-dependent manner [0.03%]
Junlei Su,Yunchong Guo,Lijun Shen et al.
Junlei Su et al.
Previous studies have established that long-term antibiotic (ABX) exposure disrupts gut microbiota, leading to adiposity, insulin resistance, and metabolic dysfunction-associated steatotic liver disease (MASLD). However, the metabolic effec...
Decoding dietary pectin: from structural complexity and microbial CAZyme-PUL networks to cross-feeding and host-beneficial metabolites [0.03%]
Guiye Li,Chen Wang,Junying Bai
Guiye Li
The interaction of pectin, as one of the most complex dietary glycans, with gut microbiota represents a typical pattern for shaping the gut microenvironment and human homeostasis. Pectin has a heterogeneous structure, characterized by homog...
Isin Y Comba,Ruben A T Mars,Lu Yang et al.
Isin Y Comba et al.
Background: Long COVID (LC) manifests in 10%-30% of non-hospitalized individuals post-SARS-CoV-2 infection, leading to significant morbidity. The predictive role of gut microbiome composition during acute infection in the...
Microbial metabolite-driven mechanisms linking the gut microbiome to atherosclerosis: multi-omic and translational perspectives [0.03%]
Mar Masiá,Félix Gutiérrez
Mar Masiá
Atherosclerotic cardiovascular disease remains the leading cause of mortality worldwide, and a substantial residual risk persists despite optimal management of traditional risk factors. Increasing evidence implicates the gut microbiome as a...
Amino acid metabolic reprogramming by gut microbiota: a novel metabolic checkpoint in the tumor microenvironment [0.03%]
肠道微生物群对氨基酸代谢的重塑：肿瘤微环境中的一种新的代谢调控点
Huiyu Lin,Xiya Deng,Yating Yang et al.
Huiyu Lin et al.
The gut microbiota plays a crucial role in human health, significantly influencing various physiological functions such as amino acid metabolism, which is essential for maintaining homeostasis and preventing disease. Recent progress in gut ...
Phocaeicola coprocola attenuates liver fibrosis by modulating extracellular matrix remodeling [0.03%]
Phocaeicola coprocola通过调节细胞外基质重塑缓解肝纤维化
Kyeong Jin Lee,Jeong Ha Park,Hyunjoon Park et al.
Kyeong Jin Lee et al.
Chronic liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), frequently progress to liver fibrosis, yet effective antifibrotic therapies remain limited. Here, we investigated the therapeutic potential ...
Synthetic microbial communities: emerging live biotherapeutics for targeted gut microbiome modulation [0.03%]
合成微生物组：针对肠道微生物群调节的新兴活体生物疗法
Ru Zhang,Hongye Li,Chunfeng Wang et al.
Ru Zhang et al.
Gut microbiome dysbiosis causes various intestinal diseases. However, an undefined composition and potential biosafety risks limit the applicability of traditional fecal microbiota transplantation (FMT). Synthetic microbial communities (Syn...
Mechanistic pathways linking gut microbial metabolites, microbial structural products, and host-microbe co-metabolites to mitochondrial function [0.03%]
肠道微生物代谢产物、微生物结构产物和宿主-菌群共代谢物与线粒体功能的机制联系路径
Richard E Frye,Daniel A Rossignol
Richard E Frye
Gut-derived microbial metabolites modulate host mitochondrial function. To our knowledge, no prior systematic review has synthesized evidence linking these metabolites to direct mitochondrial endpoints across all major metabolite classes. P...
Early-life microbiota in the LIMIT cohort: unveiling meconium microbiota types beyond maternal lifestyle [0.03%]
LIMIT队列中的生命早期微生物组：超越母体生活方式揭示胎粪微生物组类型
Dana El Masri,Niccolò Meriggi,Federica Loperfido et al.
Dana El Masri et al.
Introduction: Early gut microbiota development plays an important role in lifelong human health, and meconium offers a unique matrix to understand prenatal microbial exposures. This study from the LIMIT cohort aimed at in...
The role of adhesins of Fusobacterium nucleatum in colorectal cancer - a structural perspective [0.03%]
福斯杆菌吸附素在结直肠癌中的作用——结构视角分析
Felix Schöpf,Gian Luca Marongiu,Daniel Roderer
Felix Schöpf
Fusobacterium nucleatum is frequently found in the colon microbiome of colorectal cancer (CRC) patients. The bacterium is not only a passive bystander of CRC, but is actively involved in disease progression through mediating tumor growth st...