Using MUC2 mucin producing tumorigenic human goblet-like cells to uncover functional properties of the mucus barrier [0.03%]
利用MUC2粘蛋白产生肿瘤性人类杯状细胞样细胞揭示粘液屏障的功能属性
Hayley Gorman,France Moreau,Elise Beaupré et al.
Hayley Gorman et al.
Goblet cells are the guardians that produce MUC2 mucin that forms the protective mucus barrier as the first line of innate host defense against pathogen invasion while sustaining a healthy gut microbiota. Using an unbiased screen, we cloned...
Reciprocal oscillation and host-microbial communication in liver metabolic control [0.03%]
肝脏代谢调控中的互振和宿主-微生物交流
Jiameng Sun,Brian J DeBosch
Jiameng Sun
The liver and the gastrointestinal tract are interconnected metabolic systems, each of which possesses an intrinsic circadian rhythm. Disrupting host or microbial rhythmic oscillations alters host metabolic function, just as genetic and exo...
Rita Melo-Miranda,Ana Pinto,Hugo C Barreto et al.
Rita Melo-Miranda et al.
Laboratory-raised mice live approximately seven times longer and healthier lives compared to their wild counterparts, due to a standardized healthy diet and limited exposure to environmental stressors. Aging is associated with increased inf...
In vivo systematic analysis of microbiota-prebiotic crosstalk reveals a synbiotic that effectively ameliorates DSS-induced colitis in mice [0.03%]
体内分析微生物组-益生元相互作用的系统方法发现了有效的缓解葡聚糖硫酸钠诱导的小鼠结肠炎的合生元
Qianwen Peng,Puzi Jiang,Liwen Yi et al.
Qianwen Peng et al.
Systematic identification of prebiotic-microbe interactions is essential for developing precision microbiome-targeted interventions to improve human health. In this study, we developed an in vivo systematic screening platform to evaluate mi...
Portal bile acid composition and microbiota along the murine intestinal tract exhibit sex differences in physiology [0.03%]
小鼠肠道中性激素生理差异导致肠腔胆汁酸组分和微生物群落的性别差异
François Reichardt,Lauren N Lucas,Lydia Okyere et al.
François Reichardt et al.
Microbes in the intestine transform bile acids during transit, altering their functional and signaling capacities before recirculation via the portal vein. Sex differences in the gut microbiota have been noted, but their consequence on bile...
Disentangling the impact of obesity, diet, host factors, and microbiota on small intestinal antimicrobial peptide expression [0.03%]
肥胖、饮食、宿主因素和微生物群对小肠抗菌肽表达影响的解析研究
Fabiola Puértolas-Balint,Vishnu Prasoodanan P K,Sandra M Holmberg et al.
Fabiola Puértolas-Balint et al.
The small intestinal mucosa has the delicate task of allowing absorption of nutrients and limiting microbial colonization at the mucosal surface through production of antimicrobial peptides and proteins (AMPs). However, while environmental ...
Personalized colorectal cancer risk assessment through explainable AI and Gut microbiome profiling [0.03%]
基于解释性人工智能和肠道微生物组谱型的个性化结直肠癌风险评估
Pierfrancesco Novielli,Simone Baldi,Donato Romano et al.
Pierfrancesco Novielli et al.
The clinical adenoma - carcinoma progression represents a well-established framework for understanding colorectal cancer (CRC) development, although the molecular mechanisms underlying this transition remain only partially understood. Incre...
Role of the gut microbiome in frequent gut colonization with extended-spectrum β lactamase-producing Enterobacterales among Peruvian children [0.03%]
秘鲁儿童中广谱β-内酰胺酶肠杆菌科频繁肠道定植的肠道微生物组的作用
Maya L Nadimpalli,Neha Sehgal,Luismarcelo Rojas-Salvatierra et al.
Maya L Nadimpalli et al.
Gut colonization with extended-spectrum beta lactamase-producing Enterobacterales (ESBL-E) is increasingly common among children in low- and middle-income countries. Some children nevertheless remain never or rarely colonized during early l...
Consecutive fecal microbiota transplantation for metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial [0.03%]
代谢功能紊乱相关性肝脂肪病的连续粪菌移植疗法：一项随机对照试验
Bas Groenewegen,Merel M Ruissen,Emily Crossette et al.
Bas Groenewegen et al.
The gut microbiota is increasingly considered a contributory factor in metabolic dysfunction-associated steatotic liver disease (MASLD). This double-blind RCT evaluated the effect of three consecutive fecal microbiota transplantations (FMT)...
Randomized Controlled Trial
Gut microbes. 2025 Dec;17(1):2541035. DOI:10.1080/19490976.2025.2541035 2025
Breastfeeding and the milk resistome shape the establishment and transmission of antibiotic resistance genes in the infant gut microbiome [0.03%]
母乳喂养和奶水抗性组影响婴儿肠道菌群中抗生素抗性基因的建立与传播
Zhe Pan,Calum J Walsh,Conor Feehily et al.
Zhe Pan et al.
The infant resistome, the collection of antimicrobial resistance genes (ARGs) of newborns, is critical for gut microbiota establishment. Using metagenomic sequencing data, we analyzed various 1-week and 1-month postpartum samples to study i...