Junhua Xie,Lien Van Hoecke,Elien Van Wonterghem et al. Junhua Xie et al.

Emerging clinical and experimental evidence highlight the involvement of gut microbiota in the onset and progression of neurodegenerative diseases such as Alzheimer's disease (AD) via neuroinflammatory processes along the gut-brain axis. De...

Shaqed Carasso,Roni Keshet-David,Jia Zhang et al. Shaqed Carasso et al.

Bacterial genomic DNA inversions, which govern molecular phase-variations, provide the bacteria with functional plasticity and phenotypic diversity. These targeted rearrangements enable bacteria to respond to environmental challenges, such ...

Shuaiming Jiang,Shi Huang,Zeng Zhang et al. Shuaiming Jiang et al.

Probiotics encounter colonization resistance from native gut microbiomes, affecting their effectiveness. Genetic engineering of probiotics lacks universal applicability, as gut microbiotas are highly individualized. Here, we employed probio...

Jennifer C Pryor,Cheenie Nieva,Nicholas J Talley et al. Jennifer C Pryor et al.

Dietary gluten triggers symptoms in patients with gluten-related disorders (GRDs) including celiac disease (CeD), non-celiac gluten sensitivity (NCGS), and subsets of patients with functional dyspepsia (FD). The gastrointestinal microbiota ...

Nitin S Kamble,Shindu Thomas,Tushar Madaan et al. Nitin S Kamble et al.

The emergence of new viral pathogens necessitates innovative antiviral therapies and vaccines. Traditional approaches, such as monoclonal antibodies and vaccines, are often hindered by resistance, limited effectiveness, and high costs. Here...

Anna Samarra,Simone Renwick,Aleksandr A Arzamasov et al. Anna Samarra et al.

Breast milk, rich in human milk oligosaccharides (HMOs), supports the early-life colonization of beneficial bacteria such as bifidobacteria and lactobacilli, potentially reducing early-life antibiotic resistance. However, antibiotic treatme...

Jiaxin Deng,Jiawei Zhang,Mingli Su et al. Jiaxin Deng et al.

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide, with high incidence and mortality rates. An increasing body of research suggests that obesity is a significant risk factor for the development of CRC. Moreover, recent ...

Yan Chen,Ashley Gilliland,Qiaochu Liang et al. Yan Chen et al.

Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of daunting host defenses remain to be fully defined. For the attaching and effacing (A/E) bact...

Diane E Hoffmann,Gail H Javitt,Colleen R Kelly et al. Diane E Hoffmann et al.

Fecal microbiota transplantation (FMT) is a procedure involving the transfer of intestinal microbiota from a healthy donor to a patient to restore a functional intestinal microbiome. First described in modern science in 1958, the use of FMT...

Sabrina Mörkl,Martin Narrath,Daria Schlotmann et al. Sabrina Mörkl et al.

Major depression (MD) significantly impacts individual well-being and society. The vagus nerve plays a pivotal role in the gut-brain axis, facilitating bidirectional communication between these systems. Recent meta-analyses suggest potentia...