Depletion of butyrate-producing microbes of the Firmicutes predicts nonresponse to FMT therapy in patients with recurrent Clostridium difficile infection [0.03%]
Firmicutes 产丁酸盐菌群耗竭可预测复发性艰难梭菌感染患者粪便微生物移植治疗的无应答反应
Hongliang Tian,Jiaqu Cui,Chen Ye et al.
Hongliang Tian et al.
Approximately 10% of individuals diagnosed with Clostridium difficile infection (CDI) show the resistance to fecal microbiota transplantation (FMT), with the underlying mechanisms remaining elusive. Deciphering the intricate microbiome prof...
Shifting pattern of gut microbiota in pregnant women two decades apart - an observational study [0.03%]
二十年来孕妇肠道微生物群模式的变化——一项观察性研究
Samuli Rautava,Marta Selma-Royo,Teo Oksanen et al.
Samuli Rautava et al.
Background: Past decades have witnessed a decrease in environmental biodiversity. We hypothesized a similar decrease in indigenous gut microbiota diversity, which may have contributed to the obesity epidemic. ...
Observational Study
Gut microbes. 2023 Jan-Dec;15(1):2234656. DOI:10.1080/19490976.2023.2234656 2023
Alterations in fecal β-defensin-3 secretion as a marker of instability of the gut microbiota [0.03%]
粪便β-防御素-3分泌的变化作为肠道微生物群不稳定的标志物
Zarwa Saqib,Giada De Palma,Jun Lu et al.
Zarwa Saqib et al.
Compositional changes in the microbiota (dysbiosis) may be a basis for Irritable Bowel Syndrome (IBS), but biomarkers are currently unavailable to direct microbiota-directed therapy. We therefore examined whether changes in fecal β-defensi...
Viral metagenomics of the gut virome of diarrheal children with Rotavirus A infection [0.03%]
轮状病毒感染的儿童腹泻患者肠道病毒组的病毒宏基因组学研究
Siwen Bao,Hao Wang,Wang Li et al.
Siwen Bao et al.
Diarrhea is a leading cause of morbidity and mortality in children worldwide and represents a major dysbiosis event. Rotavirus has been recognized as a global leading pathogen of diarrhea. This study is aimed at investigating differences in...
Longitudinal flux balance analyses of a patient with episodic colonic inflammation reveals microbiome metabolic dynamics [0.03%]
纵向通量平衡分析揭示了结肠炎症发作期患者的微生物组代谢动力学
Arianna Basile,Almut Heinken,Johannes Hertel et al.
Arianna Basile et al.
We report the first use of constraint-based microbial community modeling on a single individual with episodic inflammation of the gastrointestinal tract, who has a well documented set of colonic inflammatory biomarkers, as well as metagenom...
Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity [0.03%]
肠道菌群产生的苯丙酸缓解对乙酰氨基酚引起的肝毒性
Sungjoon Cho,Xiaotong Yang,Kyoung-Jae Won et al.
Sungjoon Cho et al.
The gut microbiota affects hepatic drug metabolism. However, gut microbial factors modulating hepatic drug metabolism are largely unknown. In this study, using a mouse model of acetaminophen (APAP)-induced hepatotoxicity, we identified a gu...
Gut microbiota-related bile acid metabolism-FXR/TGR5 axis impacts the response to anti-α4β7-integrin therapy in humanized mice with colitis [0.03%]
肠道微生物群相关胆汁酸代谢-FXR/TGR5轴影响抗-α4β7整联蛋白疗法治疗结肠炎人源化小鼠的反应
Bing Han,Xiaodan Lv,Gengfeng Liu et al.
Bing Han et al.
The gut microbiota and bile acid metabolism are key determinants of the response of inflammatory bowel disease to biologic therapy. However, the molecular mechanisms underlying the interactions between the response to anti-α4β7-integrin t...
Advancing therapeutics for recurrent clostridioides difficile infections: an overview of vowst's FDA approval and implications [0.03%]
伏斯妥疗法治疗难辨梭菌重复感染：美国FDA批准概要及意义综述
Nityanand Jain,Tungki Pratama Umar,Anne-Fleur Fahner et al.
Nityanand Jain et al.
Clostridioides difficile infections (CDI) are a leading cause of healthcare-associated infections with a high relapse rate. Current treatment guidelines recommend fidaxomicin as the primary therapy for initial CDI episodes and suggest alter...
A comprehensive perspective on the interaction between gut microbiota and COVID-19 vaccines [0.03%]
肠道微生物组与COVID-19疫苗相互作用的全面分析观点
Ming Hong,Tin Lan,Qiuxia Li et al.
Ming Hong et al.
The efficacy of COVID-19 vaccines varies between individuals and populations, and the reasons for this are still not fully understood. Recent clinical studies and animal models have indicated that the gut microbiota may influence the immuno...
Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis [0.03%]
短期粘膜破坏使产 colibactin大肠杆菌能够引起长期的结肠稳态紊乱
Christine Harnack,Hilmar Berger,Lichao Liu et al.
Christine Harnack et al.
Colibactin, a bacterial genotoxin produced by E. coli strains harboring the pks genomic island, induces cytopathic effects, such as DNA breaks, cell cycle arrest, and apoptosis. Patients with inflammatory bowel diseases, such as ulcerative ...