Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis
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Colibactin, a bacterial genotoxin produced by E. coli strains harboring the pks genomic island, induces cytopathic effects, such as DNA breaks, cell cycle arrest, and apoptosis. Patients with inflammatory bowel diseases, such as ulcerative colitis, display cha... ...
