Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes [0.03%]
与结直肠癌相关的口腔条件致病菌小消化链球菌通过表观遗传学重新编程人类结肠细胞功能
Emma Bergsten,Denis Mestivier,Francoise Donnadieu et al.
Emma Bergsten et al.
Recently, an intestinal dysbiotic microbiota with enrichment in oral cavity bacteria has been described in colorectal cancer (CRC) patients. Here, we characterize and investigate one of these oral pathobionts, the Gram-positive anaerobic co...
Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis [0.03%]
线粒体功能障碍相关菌群在溃疡性结肠炎期间建立一个可传播的抗英夫利昔单抗治疗反应素体系状态
Ainize Peña-Cearra,Janire Castelo,Jose Luis Lavín et al.
Ainize Peña-Cearra et al.
Anti-TNF therapy can induce and maintain a remission status during intestinal bowel disease. However, up to 30% of patients do not respond to this therapy by mechanisms that are unknown. Here, we show that the absence of MCJ, a natural inhi...
Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting [0.03%]
关于调节退伍军人相关慢性疾病中的微生物群免疫轴的专家会议报告
Jun Sun,M Nedim Ince,Clara Abraham et al.
Jun Sun et al.
The present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled "Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans." Our Veteran patient population experi...
Targeting hypoxia-inducible factor-1 alpha suppresses Helicobacter pylori-induced gastric injury via attenuation of both cag-mediated microbial virulence and proinflammatory host responses [0.03%]
靶向低氧诱导因子-1α通过减轻I型超敏反应和宿主炎症反应抑制幽门螺旋杆菌所致胃部损伤
Jennifer M Noto,M Blanca Piazuelo,Judith Romero-Gallo et al.
Jennifer M Noto et al.
Helicobacter pylori-induced inflammation is the strongest known risk factor for gastric adenocarcinoma. Hypoxia-inducible factor-1 (HIF-1α) is a key transcriptional regulator of immunity and carcinogenesis. To examine the role of this medi...
Current insights on the roles of gut microbiota in inflammatory bowel disease-associated extra-intestinal manifestations: pathophysiology and therapeutic targets [0.03%]
肠道微生物在炎症性肠病相关肠外表现中的作用的当前见解：病理生理和治疗靶点
Yizhe Tie,Yongle Huang,Rirong Chen et al.
Yizhe Tie et al.
Inflammatory bowel disease (IBD) is a chronic, recurrent inflammatory disease of the gastrointestinal tract. In addition to digestive symptoms, patients with IBD may also develop extra-intestinal manifestations (EIMs), the etiology of which...
Mimicry of microbially-derived butyrate reveals templates for potent intestinal epithelial HIF stabilizers [0.03%]
模仿微生物来源丁酸揭示了强力稳定肠上皮细胞HIF的模板
Alfredo Ornelas,Nichole Welch,Jacob A Countess et al.
Alfredo Ornelas et al.
Microbiota-derived short-chain fatty acids, including butyrate (BA), have multiple beneficial health effects. In the colon, BA concentrations range from 10 to 20 mM and up to 95% is utilized as energy by the mucosa. BA plays a key role in e...
Microbial-host-isozyme: unveiling a new era in microbiome-host interaction [0.03%]
微生物-宿主同工酶：揭示微生物组-宿主互作的新时代
Lei Miao,Herbert Tilg,Ming-Hua Zheng
Lei Miao
Wang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota-host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that...
Identification of a functional peptide of a probiotic bacterium-derived protein for the sustained effect on preventing colitis [0.03%]
一种益生菌蛋白衍生功能肽的鉴定及其持续预防结肠炎的作用
Harpreet Kaur,Syed Azmal Ali,Sarah P Short et al.
Harpreet Kaur et al.
Several probiotic-derived factors have been identified as effectors of probiotics for exerting beneficial effects on the host. However, there is a paucity of studies to elucidate mechanisms of their functions. p40, a secretory protein, is o...
Parity modulates impact of BMI and gestational weight gain on gut microbiota in human pregnancy [0.03%]
性别调节BMI和妊娠期增重对人类妊娠期间肠道微生物的影响
Katherine M Kennedy,Andreas Plagemann,Julia Sommer et al.
Katherine M Kennedy et al.
Dysregulation of maternal adaptations to pregnancy due to high pre-pregnancy BMI (pBMI) or excess gestational weight gain (GWG) is associated with worsened health outcomes for mothers and children. Whether the gut microbiome contributes to ...
PUFAs add fuel to Crohn's disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation [0.03%]
多不饱和脂肪酸通过加剧肠上皮脂质过氧化来为与克罗恩病相关AIEC诱导的肠炎添加燃料
Weiwei Wen,Yihan Xu,Wenwei Qian et al.
Weiwei Wen et al.
Polyunsaturated fatty acids (PUFAs) have been shown to exacerbate Crohn's disease (CD) by promoting lipid peroxidation (LPO) of intestinal epithelial cells (IECs). Dysbiosis of the gut microbiota may play a crucial role in this process. CD ...