Mimicry of microbially-derived butyrate reveals templates for potent intestinal epithelial HIF stabilizers
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Microbiota-derived short-chain fatty acids, including butyrate (BA), have multiple beneficial health effects. In the colon, BA concentrations range from 10 to 20 mM and up to 95% is utilized as energy by the mucosa. BA plays a key role in epithelial-barrier re... ...