Peripheral nerve-mediated glucose lowering: Mechanisms, translational strategies, and future perspectives [0.03%]
外周神经介导的降糖机制、转化策略及未来展望
Shuai-Yan Wang,Xin Liu,Zi-Mu Li et al.
Shuai-Yan Wang et al.
Glucose homeostasis is crucial for metabolic health, with disruptions leading to hyperglycemia (e.g., diabetes affecting over 589 million adults worldwide in 2025) or hypoglycemia, both associated with severe complications like nephropathy,...
Transverse tibial bone transport promotes distraction osteogenesis and improves blood flow in the management of diabetic foot [0.03%]
横向胫骨骨运输促进牵张成骨并改善糖尿病足血运管理中的血液循环
Mei-Mei Liao,Fan Zhang,Yi-Kai Wang et al.
Mei-Mei Liao et al.
Background: Diabetic foot ulcers (DFUs), a common and severe long-term complication of diabetes, are associated with high rates of amputation and mortality. Transverse tibial bone transport (TTT) has recently been applied...
Targeting N-methyl-D-aspartate 2B receptor in painful diabetic neuropathy - mechanisms, challenges, and emerging therapeutics [0.03%]
针对痛性糖尿病神经病变的N-甲基-D-天冬氨酸2B受体的作用机制、挑战及新兴疗法
Nayab Khalid,Nazlahshaniza Shafin,Idris Long et al.
Nayab Khalid et al.
A notable number of patients with diabetes suffer from painful diabetic neuropathy (PDN), which is a debilitating complication of diabetes mellitus. Prolonged hyperglycaemia and metabolic dysregulation lead to PDN, a condition characterised...
Role of fasting glucose and glycated hemoglobin for gestational diabetes mellitus diagnosis: A prospective study [0.03%]
妊娠糖尿病诊断中空腹血糖和糖化血红蛋白的作用：一项前瞻性研究
María Molina-Vega,Maria J Estébanez-Prieto,Andrea Fernández-Valero et al.
María Molina-Vega et al.
Background: Fasting glucose and glycated hemoglobin (HbA1c) were used to diagnose gestational diabetes during the coronavirus disease 2019 (COVID-19) pandemic. ...
Microtubule affinity-regulating kinase 4 exacerbates diabetic cardiomyopathy by inhibiting UNC-51-like kinase 1-mediated mitochondrial autophagy [0.03%]
微管亲和调节激酶4通过抑制UNC-51样激酶1介导的线粒体自噬加剧糖尿病心肌病
Yi Wu,Wei-Yi Wang,Jing-Qi Zhang et al.
Yi Wu et al.
Background: The incidence of diabetic cardiomyopathy (DCM) is increasing significantly as the population ages. DCM is one of the main causes of heart failure and mortality among patients with diabetes. Impaired mitophagy ...
Guido Gembillo,Luca Soraci,Rossella Messina et al.
Guido Gembillo et al.
Diabetic kidney disease (DKD) represents a significant challenge for diabetes management and public health as it affects the quality of life and metabolic control of millions of people around the world. Characterized by persistent albuminur...
Improving metabolic and inflammatory balance prevents periodontal complications in diabetes [0.03%]
代谢和炎症平衡的改善可以预防糖尿病患者的牙周并发症
Hong-Wei Tang,Nan Zhang
Hong-Wei Tang
Recent real-world evidence suggests that improved regulation of metabolic and inflammatory pathways can substantially lower the risk of periodontal complications in individuals with type 2 diabetes. Periodontitis, a frequent yet often overl...
Endothelial cell-derived exosomes inhibit high glucose-induced osteoblast ferroptosis by activating microRNA-335-3p/prostaglandin endoperoxide synthase 2 [0.03%]
内皮细胞来源的外泌体通过激活microRNA-335-3p/前列腺素末端过氧化物合酶2抑制高糖诱导的成骨细胞铁死亡
Chen Shao,Li-Jian Zhang,Yi-Lin Song et al.
Chen Shao et al.
Background: Diabetic osteoporosis (DOP), a serious complication of type 2 diabetes mellitus (T2DM), involves ferroptosis-mediated disruption of bone metabolism. While endothelial cell-derived exosomes (EC-Exos) demonstrat...
Exosomal miR-375-3p as a mediator of pancreas-liver crosstalk in impaired hepatic glycogenesis [0.03%]
miR-375-3p介导的胰腺-肝脏对话在肝糖原生成受损中的作用
Tian-Han Xu,Dong-Mei Wang
Tian-Han Xu
Type 2 diabetes mellitus is a complex metabolic disorder characterized by impaired insulin secretion, insulin resistance, and dysregulated inter-organ communication. Beyond classical endocrine signaling, exosomes have recently emerged as cr...
Commentary on α-1-microglobulin as a predictor of diabetic complications [0.03%]
α-1微球蛋白预测糖尿病并发症的评论文章
Li Liao,An Luo,Long-Han Zhang et al.
Li Liao et al.
This letter comments on the study by Ge et al. Serum α1-microglobulin (α1-MG) was reported to be associated with diabetic nephropathy, retinopathy, peripheral neuropathy, and left ventricular hypertrophy. The letter further highlights the...