Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches [0.03%]
整合蛋白质组学和转录组学方法识别糖尿病神经病变的新型治疗靶点
Xue-Feng Ding,Xin Dang,Shan Lin
Xue-Feng Ding
Background: Diabetic neuropathy (DN) is a progressive disorder with limited effective treatment options. Aim: To identify potential the...
Beyond the left ventricle: Right ventricular dysfunction as a critical determinant in type 1 diabetes-related cardiomyopathy [0.03%]
超越左心室：右心室功能不全在1型糖尿病相关心肌病中的关键作用
Tong-Jian Zhao,Nian-Zhe Sun
Tong-Jian Zhao
Diabetic cardiomyopathy (DCM) has long been considered as a left ventricular (LV) disease with diastolic dysfunction preceding systolic dysfunction in diabetes. However, it is increasingly recognized that the right ventricle (RV) is also af...
Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes [0.03%]
肾周脂肪和酒精消耗对2型糖尿病患者接受牙种植术后边缘骨丢失的贡献
Jelena S Jadzic,Vladan D Kekovic
Jelena S Jadzic
We read with great interest the article by Li et al, reporting an observational study on the inflammatory response-mediated bone loss after dental implant surgery in patients with type 2 diabetes mellitus (T2DM). This study provides relevan...
Rheb1 signaling and the fate of pancreatic β cells: Toward a new frontier in diabetes therapy [0.03%]
雷尔布林蛋白1信号传导与胰岛β细胞的命运：糖尿病治疗的新前沿领域
Hadi Karimkhani
Hadi Karimkhani
A recent study in the World Journal of Diabetes by Yang et al explored how Rheb1 signaling influenced pancreatic β cell fate and its potential as a therapeutic target. This invited commentary by a senior diabetes researcher discussed the f...
From fatty liver indices to the Zhejiang University index: Re-shaping risk stratification of metabolic liver disease in diabetes [0.03%]
从脂肪肝指数到浙大糖尿病肝病风险预测指数：重塑糖尿病代谢相关肝病的风险分层
Mostafa M Gouda
Mostafa M Gouda
This editorial comments on the study by Tao et al, emphasizing the scalable diagnostic tool for metabolic dysfunction-associated steatotic liver disease (MASLD) in type 2 diabetes mellitus (T2DM). Classical indices such as the fatty liver i...
Longitudinal assessment of pancreatic exocrine dysfunction in type 1 diabetes [0.03%]
1型糖尿病患者的胰腺外分泌功能障碍的纵向评估
Federico Bolado,Lucía Zabalza,Joaquín de-Carlos et al.
Federico Bolado et al.
Background: Previous studies have shown that individuals with type 1 diabetes (T1D) frequently present with reduced fecal elastase levels, suggesting exocrine pancreatic insufficiency. However, the underlying determinants...
Liraglutide alleviates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by enhancing mitophagy mediated by the AMPK-Parkin signaling pathway [0.03%]
利拉鲁肽通过激活AMPK-帕金蛋白信号通路增强线粒体自噬缓解链脲佐菌素诱导的糖尿病大鼠心肌病
Ya-Xin Zhu,Wei Zhang,Hui-Lin Qu et al.
Ya-Xin Zhu et al.
Background: Recent studies have shown that liraglutide, a glucagon-like peptide-1 receptor agonist, has unexpected cardioprotective effects. However, the distinctive effects of liraglutide on diabetic cardiomyopathy (DCM)...
Addressing the dual challenge: Managing smoking cessation in patients with diabetes [0.03%]
应对双重挑战：糖尿病患者的戒烟管理
Cristina Russo,Magdalena Walicka,Gal Cohen et al.
Cristina Russo et al.
Smoking increases complications and mortality in people with diabetes. Quitting delivers major benefits, but physiological (weight gain, insulin sensitivity shifts) and psychological barriers make cessation harder in this group. Our review ...
Immune activation induced by dysregulated lipid metabolism in the pathogenesis of type 2 diabetes [0.03%]
脂代谢紊乱诱发免疫激活在2型糖尿病发病机制中的作用
Hao-Yu Yang,Yu Wei,Qin Mao et al.
Hao-Yu Yang et al.
Type 2 diabetes mellitus (T2DM) is characterized by two core pathological features: Insulin resistance and β-cell dysfunction, with dyslipidemia and immune dysregulation playing critical roles in its pathogenesis. Ectopic lipid deposition ...
Glycemic control, weight-loss effects, and safety of cotadutide in individuals with type 2 diabetes: A systematic review and meta-analysis [0.03%]
cotadutide对2型糖尿病患者血糖控制、体重减轻及安全性的影响：系统评价和meta分析
Abul Bashar Mohammad Kamrul-Hasan,Deep Dutta,Lakshmi Nagendra et al.
Abul Bashar Mohammad Kamrul-Hasan et al.
Background: Cotadutide (MEDI0382) is a twincretin that acts as an agonist for both the glucagon-like peptide-1 and glucagon receptors. Several randomized controlled trials (RCTs) have been published evaluating the use of ...