Glucagon-like peptide-1 and impaired counterregulatory responses to hypoglycemia in type 1 diabetes [0.03%]
葡萄糖苷酸肽-1及1型糖尿病患者低血糖不适当的调节反应
Gabriel Reis Rocha,Fabrício Freire de Melo
Gabriel Reis Rocha
This letter comments on a study by Jin et al, published recently in the World Journal of Diabetes. Hypoglycemia is a significant complication of diabetes, with primary defense mechanisms involving the stimulation of glucagon secretion in α...
L-arginine administration exacerbates myocardial injury in diabetics via prooxidant and proinflammatory mechanisms along with myocardial structural disruption [0.03%]
L-精氨酸通过促氧化和促炎机制以及心肌结构破坏加重糖尿病患者的心肌损伤
Rasha A Mansouri,Esam M Aboubakr,Huda F Alshaibi et al.
Rasha A Mansouri et al.
Background: L-arginine (L-Arg) is one of the most widely used amino acids in dietary and pharmacological products. However, the evidence on its usefulness and dose limitations, especially in diabetics is still controversi...
Impact of setting distinct target blood glucose levels on endogenous insulin suppression and pharmacodynamics of insulin preparations [0.03%]
设定不同的目标血糖水平对内源性胰岛素抑制及胰岛制剂药效动力学的影响
Hui Liu,Ting Li,Xin-Lei Chen et al.
Hui Liu et al.
Background: Insulin therapy plays a crucial role in managing diabetes. Regulatory guidelines mandate assessing the pharmacokinetics (PK) and pharmacodynamics (PD) of new insulin formulations with euglycemic clamp techniqu...
Transcriptome and single-cell profiling of the mechanism of diabetic kidney disease [0.03%]
糖尿病肾病机制的转录组和单细胞分析
Ying Zhou,Xiao Fang,Lin-Jing Huang et al.
Ying Zhou et al.
Background: The NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome may play an important role in diabetic kidney disease (DKD). However, the exact link remains unclear. ...
Insulin autoantibodies, D-dimer and microalbuminuria: A cross-sectional, case-control study of type 2 diabetes [0.03%]
胰岛素自身抗体、D-二聚体和微量白蛋白尿：2型糖尿病的横断面病例对照研究
Lin-Shan Zhang,Peng Yu,Fei Yao et al.
Lin-Shan Zhang et al.
Background: Type 2 diabetes mellitus (T2DM) often leads to vascular complications, such as albuminuria. The role of insulin autoantibodies (IAA) and their interaction with D-dimer in this context remains unclear. ...
Renal effects and safety of tirzepatide in subjects with and without diabetes: A systematic review and meta-analysis [0.03%]
系统评价与荟萃分析：是否存在糖尿病受试者中Tirzepatide的肾影响和安全性
Abm Kamrul-Hasan,Shinjan Patra,Deep Dutta et al.
Abm Kamrul-Hasan et al.
Background: Type 2 diabetes (T2D), as well as obesity, are risk factors for chronic kidney disease (CKD) and end-stage renal disease. The renal impacts of glucose-lowering and weight-lowering drugs and their potential ben...
Bo Yi,Yan Bao,Zhong-Yuan Wen
Bo Yi
Background: Although numerous single nucleotide polymorphism in multiple genes involve in the risk of type 2 diabetes mellitus (T2D), the single gene defects of T2D with strong family history is not clear yet. SPTLC1 are ...
Tacrolimus induces insulin receptor substrate 1 hyperphosphorylation and inhibits mTORc1/S6K1 cascade in HL7702 cells [0.03%]
他克莫司诱导胰岛素受体底物1过度磷酸化并抑制HL7702细胞中的mTORc1/S6K1级联反应
Hao-Yan Li,Yi Wang,Min Ran et al.
Hao-Yan Li et al.
Background: Tacrolimus (FK506) is a key calcineurin inhibitor used to prevent organ transplant rejection and is effective in improving graft survival. However, it is linked to hyperglycemia and insulin resistance, contrib...
Evaluating the effectiveness of ultrasound-assisted wound debridement in managing diabetic foot ulcers: A systematic review and meta-analysis [0.03%]
评估超声辅助清创术在管理糖尿病足溃疡中的效果：系统评价和荟萃分析
Rui Yang,Geng Chen,Qing-Yun Pan et al.
Rui Yang et al.
Background: Diabetic foot ulcers (DFUs) present a significant clinical challenge due to their high prevalence and profound impact on morbidity. Ultrasound-assisted wound debridement (UAWD) has emerged as a potential thera...
Correlation between diabetic peripheral neuropathy and thyroid hormone sensitivity in elderly patients with type 2 diabetes mellitus [0.03%]
2型糖尿病老年患者甲状腺激素敏感性与周围神经病变的相关性研究
Si-Jia Fei,Jing-Yi Luo,Wei-Hao Wang et al.
Si-Jia Fei et al.
Background: Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes mellitus (T2DM), significantly affecting patients' quality of life and imposing a substantial economic burden. Recent studies ha...