Aβ8-20 Fragment as an Anti-Fibrillogenic and Neuroprotective Agent: Advancing toward Efficient Alzheimer's Disease Treatment [0.03%]
一种抗纤维变性和神经保护剂的片段：迈向有效的阿尔茨海默病治疗药物
Stefania Zimbone,Maria Laura Giuffrida,Giuseppina Sabatino et al.
Stefania Zimbone et al.
Alzheimer's disease (AD) is the most common cause of dementia, characterized by a spectrum of symptoms associated with memory loss and cognitive decline with deleterious consequences in everyday life. The lack of specific drugs for the trea...
Propofol-Induced Developmental Neurotoxicity: From Mechanisms to Therapeutic Strategies [0.03%]
异丙酚致发育神经毒性：从机制到治疗策略
Jing Zhang,Yu Li
Jing Zhang
Propofol is the most commonly used intravenous general anesthetic in clinical anesthesia, and it is also widely used in general anesthesia for pregnant women and infants. Some clinical and preclinical studies have found that propofol causes...
Antidepressant Potential of a Functionalized 3-Selanyl Benzo[ b]Furan Compound in Mice: Focus on the Serotonergic System [0.03%]
一种功能化3-硒代苯并呋喃化合物的抗抑郁潜力：重点研究五羟色胺系统
Taís da Silva Teixeira Rech,Estela Hartwig Ribeiro,Ediandra Tissot Castro et al.
Taís da Silva Teixeira Rech et al.
The present study investigated the antidepressant-like potential of a functionalized 3-selanyl benzo[b]furan (SeBZF) in male Swiss mice. To evaluate possible antidepressant-like actions, the compounds SeBZF1-5 (50 mg/kg, intragastric, i.g.,...
2-(4-Fluorophenyl)-1 H-benzo[ d]imidazole as a Promising Template for the Development of Metabolically Robust, α1β2γ2GABA-A Receptor-Positive Allosteric Modulators [0.03%]
以2-(4-氟苯基)-1 H-苯并[d]咪唑为模板，开发具有代谢稳定性的α1β2γ2 GABAA受体阳性 allosteric调制剂
Monika Marcinkowska,Nikola Fajkis-Zajączkowska,Katarzyna Szafrańska et al.
Monika Marcinkowska et al.
Modulation of α1β2γ2GABA-A receptor subpopulation expressed in the basal ganglia region is a conceptually novel mode of pharmacological strategy that offers prospects to tackle a variety of neurological dysfunction. Although clinical fin...
Mitochondrial Inhibitor Rotenone Triggers and Enhances Neuronal Ferroptosis Following Intracerebral Hemorrhage [0.03%]
线粒体抑制剂鲁斯弗汀诱发并加重脑出血后神经元铁死亡
Yijun Cheng,Ziqian Zhang,Hao Tang et al.
Yijun Cheng et al.
Ferroptosis, a form of regulatory non-apoptotic cell death driven by iron-dependent lipid peroxidation, accounts for more than 80% of the total types of neuronal death in the acute phase of intracerebral hemorrhage (ICH). Mitochondria have ...
Prostaglandin D2 Controls Local Blood Flow and Sleep-Promoting Neurons in the VLPO via Astrocyte-Derived Adenosine [0.03%]
VPo区由星形胶质细胞源性腺苷介导的PGD2对局部血流和促进睡眠神经元的调控作用
Emeric Scharbarg,Augustin Walter,Laure Lecoin et al.
Emeric Scharbarg et al.
Prostaglandin D2 (PGD2) is one of the most potent endogenous sleep-promoting molecules. However, the cellular and molecular mechanisms of the PGD2-induced activation of sleep-promoting neurons in the ventrolateral preoptic nucleus (VLPO), t...
GianPietro Sechi,M Margherita Sechi
GianPietro Sechi
In neonates with hypoxic-ischemic encephalopathy (HIE), neuroprotection mediated by therapeutic hypothermia (TH) is the standard of care in developed nations; however TH may be not beneficial or contraindicated in developing world. Moreover...
Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization [0.03%]
ivermectin与α7nAChR的结合及诱导通道失活的机制研究
Vasyl Bondarenko,Qiang Chen,Kevin Singewald et al.
Vasyl Bondarenko et al.
The α7 nicotinic acetylcholine receptor (α7nAChR) mediates signaling in the central nervous system and cholinergic anti-inflammatory pathways. Ivermectin is a positive allosteric modulator of a full-length α7nAChR and an agonist of the ...
Lactocaseibacillus rhamnosus zz-1 Supplementation Mitigates Depression-Like Symptoms in Chronic Stress-Induced Depressed Mice via the Microbiota-Gut-Brain Axis [0.03%]
鼠李糖乳酪片球菌zz-1通过微生物群-肠道-大脑轴缓解慢性压力小鼠的抑郁样症状
Jinzhao Xu,Mengqi Tang,Danping Wang et al.
Jinzhao Xu et al.
Accumulating evidence has revealed an association between depression and disordered intestinal microecology. The discovery of psychobiotics has provided a promising perspective for studying the treatment of psychiatric disorders. Here, we a...
Design, Synthesis, and Pharmacological Evaluation of Embelin-Aryl/alkyl Amine Hybrids as Orally Bioavailable Blood-Brain Barrier Permeable Multitargeted Agents with Therapeutic Potential in Alzheimer's Disease: Discovery of SB-1448 [0.03%]
设计、合成和药理学评价：新型姜根素-芳基/烷基胺衍生物作为多重靶向阿尔茨海默病治疗的口服易吸收且可通过血脑屏障的新一代药物分子：SB-1448的发现
Vijay K Nuthakki,Sushil Choudhary,Chilakala N Reddy et al.
Vijay K Nuthakki et al.
The complex and multifaceted nature of Alzheimer's disease has brought about a pressing demand to develop ligands targeting multiple pathways to combat its outrageous prevalence. Embelin is a major secondary metabolite of Embelia ribes Burm...