Photoactivatable Agonist-Antagonist Pair as a Tool for Precise Spatiotemporal Control of Serotonin Receptor 2C Signaling [0.03%]
光激活激动剂-拮抗剂对作为一种精确控制血清素受体2C信号时空分布的工具
Spencer T Kim,Emma J Doukmak,Michelle Shanguhyia et al.
Spencer T Kim et al.
Orthogonal recreation of the signaling profile of a chemical synapse is a current challenge in neuroscience. This is due in part to the kinetics of synaptic signaling, where neurotransmitters are rapidly released and quickly cleared by acti...
Liquid-Liquid Phase Separation (LLPS)-Driven Fibrilization of Amyloid-β Protein [0.03%]
液滴凝聚促进淀粉样蛋白原纤维化现象
Swathi Sudhakar,Anagha Manohar,Ethayaraja Mani
Swathi Sudhakar
Amyloid-β [Aβ(1-40)] aggregation into a fibrillar network is one of the major hallmarks of Alzheimer's disease (AD). Recently, a few studies reported that polyphosphate (polyP), an anionic biopolymer that participates in various cellular ...
Basolateral Amygdala Cannabinoid CB1 Receptor Controls Formation and Elimination of Social Fear Memory [0.03%]
基底外侧杏仁核的 cannabinoid cb1 受体控制社交恐惧记忆的形成与消退
Ming Li,Xinyuan Lv,Tongxia Li et al.
Ming Li et al.
Patients with post-traumatic stress disorder (PTSD) usually manifest persistence of the traumatic memory for a long time after the event, also known as resistance to extinction learning. Numerous studies have shown that the endocannabinoid ...
Photoactivated Protein Degrader for Optical Control of Synaptic Function [0.03%]
光控蛋白降解小分子开关及其在突触功能研究中的应用
Tongil Ko,Claudia Jou,Alejandro B Grau-Perales et al.
Tongil Ko et al.
Hundreds of proteins determine the function of synapses, and synapses define the neuronal circuits that subserve myriad brain, cognitive, and behavioral functions. It is thus necessary to precisely manipulate specific proteins at specific s...
Exploring the Barriers in the Aggregation of a Hexadecameric Human Prion Peptide through the Markov State Model [0.03%]
马尔可夫状态模型在人源四聚体朊病毒肽组装中的应用研究
Bratin Kumar Das,Omkar Singh,Debashree Chakraborty
Bratin Kumar Das
The prefibrillar aggregation kinetics of prion peptides are still an enigma. In this perspective, we employ atomistic molecular dynamics (MD) simulations of the shortest human prion peptide (HPP) (127GYMLGS132) at various temperatures and p...
Qi Wang,Jingyi Sun,Tian Chen et al.
Qi Wang et al.
Alzheimer's disease (AD), the most common type of dementia, is a neurodegenerative disorder characterized by progressive cognitive dysfunction. Epidemiological investigation has demonstrated that, after cardiovascular and cerebrovascular di...
Tiantian Zhao,Aiwen Chen,Danqing Dai et al.
Tiantian Zhao et al.
Re-examining the relationship between neuropeptide systems and neural circuits will help us to understand more intensively the critical role of neuropeptides in brain function as the neural circuits responsible for specific brain functions ...
Destabilizing Effect of Organo Ru(II) Salts on the Intermolecular Parallel CGG Repeat DNA Quadruplex Associated with Neurodegenerative/Neuromuscular Diseases [0.03%]
有机钌(II)盐破坏碱基重复序列的CGG平行四链体结构对神经退行性疾病和肌萎缩侧索硬化症的影响研究
Chakkarai Sathyaseelan,Sabari Veerapathiran,Uttam Das et al.
Chakkarai Sathyaseelan et al.
The cationic organo ruthenium(II) salts ([Ru(p-cymene)(ipit)(Cl)](Cl) (RuS), 1-isopropyl-3-(pyridin-2-yl)-imidazol-2-thione (ipit) and [Ru(p-cymene)(ipis)(Cl)](Cl) (RuSe), 1-isopropyl-3-(pyridin-2-yl)-imidazol-2-selenone (ipis)) are isolate...
Study on the Difference of Protective Efficacy and Mechanism of Radix Aconiti Coreani and Rhizoma Typhonii in Gerbils with Ischemic Stroke [0.03%]
附子与禹余粮防治血管性痴呆的效用及差异机制研究
Liting Zhou,Ru Jia,Wanting Zeng et al.
Liting Zhou et al.
Ischemic stroke is a common type of stroke, but effective treatment methods are still imperfect and new effective therapies need to be explored. Radix Aconiti Coreani and Rhizoma Typhonii used as Baifuzi in the treatment of stroke or sympto...
Intranasal Route: A Nasocerebral Approach against SARS-CoV-2 in NeuroCOVID [0.03%]
鼻腔给药途径：针对神经型新冠患者的鼻脑靶向SARS-CoV-2疗法
Abdul Mannan Baig,Joachim Gerlach
Abdul Mannan Baig
The nasal cavity is a prime site for viral load of SARS-CoV-2 in COVID-19, as is evident from the fact that this area has been used for sample collection for the diagnosis of COVID-19. The nasal cavity has a connection with the brain across...