Initiation of Brain Extract Fibrillation and Effective Cellular Internalization of Tryptophan Fibrils Unveils Its Neurotoxicity Risk [0.03%]
脑提取物纤维化和色氨酸纤维细胞内吞作用的启动揭示了其神经毒性风险
Kailash Prasad Prajapati,Masihuzzaman Ansari,Shikha Mittal et al.
Kailash Prasad Prajapati et al.
Recent discoveries on the self-assembly of aromatic amino acids into amyloid-like neurotoxic nanostructures have initiated a quest to decode the molecular mechanisms for the initiation of neurodegeneration. Moreover, the multicomponent natu...
Walaa Hamada Abd-Allah,Mostafa Abd El-Mohsen Anwar,Eman R Mohammed et al.
Walaa Hamada Abd-Allah et al.
Epilepsy is considered one of the most common neurological disorders worldwide; it needs long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs, approximately 30% patients still suffer from drug-resistan...
Evaluation of trans- and cis-4-[18F]Fluorogabapentin for Brain PET Imaging [0.03%]
评价茋和反式-4-氟呱乙啶的脑PET显影效果研究
Yu-Peng Zhou,Marc D Normandin,Vasily Belov et al.
Yu-Peng Zhou et al.
Gabapentin, a selective ligand for the α2δ subunit of voltage-dependent calcium channels, is an anticonvulsant medication used in the treatment of neuropathic pain, epilepsy, and other neurological conditions. We recently described two ra...
Molecular Dynamics Activation of γ-Secretase for Cleavage of the Notch1 Substrate [0.03%]
γ-分泌酶的分子动力学激活以剪切Notch1底物
Hung N Do,Shweta R Malvankar,Michael S Wolfe et al.
Hung N Do et al.
γ-Secretase is an intramembrane aspartyl protease complex that cleaves the transmembrane domain of over 150 peptide substrates, including amyloid precursor protein (APP) and the Notch family of receptors, via two conserved aspartates D257 ...
Shared and Unique Disease Pathways in Amyotrophic Lateral Sclerosis and Parkinson's Disease Unveiled in Peripheral Blood Mononuclear Cells [0.03%]
外周血单个核细胞中揭示肌萎缩侧索硬化和帕金森病的共享及特有疾病途径
Marta Lualdi,Federico Casale,Mario Giorgio Rizzone et al.
Marta Lualdi et al.
Recent evidence supports an association between amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). Indeed, prospective population-based studies demonstrated that about one-third of ALS patients develop parkinsonian (PK) signs...
Development of a P-tau217 Electrochemiluminescent Immunosensor Reinforced with Au-Cu Nanoparticles for Alzheimer's Disease Precaution [0.03%]
基于Au-Cu纳米粒子的电致化学发光免疫传感器检测P-tau217用于阿尔茨海默病预防筛查研究
Susu Kong,Xi Wen,Yueju Wang et al.
Susu Kong et al.
To simply and rapidly detect the highly phosphorylated tau protein at threonine 217 (p-tau217) as a precautionary measure against Alzheimer's disease and distinguish it from other neurodegenerative diseases, a novel immunosensor was prepare...
Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose [0.03%]
肠道氧化还原生物标志物在无症状和有症状Tg2576小鼠阿尔茨海默病模型中的探索性研究：表型相关性和慢性口服d-半乳糖的影响
Jan Homolak,Ana Babic Perhoc,Ana Knezovic et al.
Jan Homolak et al.
The gut might play an important role in the etiopathogenesis of Alzheimer's disease (AD) as gastrointestinal alterations often precede the development of neuropathological changes in the brain and correlate with disease progression in anima...
Curcumin Reduces Amyloid Beta Oligomer Interactions with Anionic Membranes [0.03%]
姜黄素减少与阴离子膜的β淀粉样蛋白低聚体相互作用
Chad A Sallaberry,Barbie J Voss,William B Stone et al.
Chad A Sallaberry et al.
Many neurodegenerative diseases involve amyloidogenic proteins forming surface-bound aggregates on anionic membranes, and the peptide amyloid β (Aβ) in Alzheimer's disease is one prominent example of this. Curcumin is a small polyphenolic...
Patient Brain Organoids Identify a Link between the 16p11.2 Copy Number Variant and the RBFOX1 Gene [0.03%]
患者脑器官识别出16p11.2拷贝数变异与RBFOX1基因之间的关联
Milos Kostic,Joseph J Raymond,Christophe A C Freyre et al.
Milos Kostic et al.
Copy number variants (CNVs) that delete or duplicate 30 genes within the 16p11.2 genomic region give rise to a range of neurodevelopmental phenotypes with high penetrance in humans. Despite the identification of this small region, the mecha...
Understanding the Molecular Mechanisms of Polyphenol Inhibition of Amyloid β Aggregation [0.03%]
理解多酚抑制淀粉样蛋白β聚集的分子机制
Yin-Lei Han,Huan-Huan Yin,Chao Xiao et al.
Yin-Lei Han et al.
Alzheimer's disease (AD) is highly associated with self-aggregation of amyloid β (Aβ) proteins into fibrils. Inhibition of Aβ aggregation by polyphenols is one of the major therapeutic strategies for AD. Among them, four polyphenols (bra...