Molecular Dynamics Activation of γ-Secretase for Cleavage of the Notch1 Substrate
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γ-Secretase is an intramembrane aspartyl protease complex that cleaves the transmembrane domain of over 150 peptide substrates, including amyloid precursor protein (APP) and the Notch family of receptors, via two conserved aspartates D257 and D385 in the pres... ...
