Glutathione Depletion and Concomitant Elevation of Susceptibility in Patients with Parkinson's Disease: State-of-the-Art MR Spectroscopy and Neuropsychological Study [0.03%]
谷胱甘肽耗竭与帕金森病患者的伴随易感性升高：目前的磁共振波谱学和神经心理学研究水平
Deepika Shukla,Anshika Goel,Pravat K Mandal et al.
Deepika Shukla et al.
Parkinson's disease (PD) is characterized by extrapyramidal motor disturbances and nonmotor cognitive impairments which impact activities of daily living. Although the etiology of PD is still obscure, autopsy reports suggest that oxidative ...
Computationally Designed Molecules Modulate ALS-Related Amyloidogenic TDP-43307-319 Aggregation [0.03%]
计算设计的分子可调节ALS相关淀粉样蛋白生成型TDP-43307-319聚集作用
Xikun Liu,Shuya Duan,Yingying Jin et al.
Xikun Liu et al.
Abnormal cytosolic aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is observed in multiple diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration, and Alzheimer's disease. Previous studies have ...
Jing Hu,Sara Linse,Emma Sparr
Jing Hu
Amyloid β peptide (Aβ) is the crucial protein component of extracellular plaques in Alzheimer's disease. The plaques also contain gangliosides lipids, which are abundant in membranes of neuronal cells and in cell-derived vesicles and exos...
Neuroprotective Profile of Triazole Grandisin Analogue against Amyloid-Beta Oligomer-Induced Cognitive Impairment [0.03%]
三唑衍生物grandisin防治淀粉样蛋白寡聚体致认知障碍的神经保护作用研究
Victor H B de Andrade,Erick Y M Rodrigues,Nayara A F Dias et al.
Victor H B de Andrade et al.
Alzheimer's disease (AD) is a neurodegenerative disorder caused by accumulation of amyloid-β oligomers (AβO) in the brain, neuroinflammation, oxidative stress, and cognitive decline. Grandisin, a tetrahydrofuran neolignan, exhibits releva...
Synthesis and Preclinical Evaluation of 22-[18F]Fluorodocosahexaenoic Acid as a Positron Emission Tomography Probe for Monitoring Brain Docosahexaenoic Acid Uptake Kinetics [0.03%]
一种监测大脑二十碳六烯酸摄取动力学的正电子发射断层显像探针22-[18F]氟二十二碳六烯酸的合成与临床前评估研究
Marlon Vincent V Duro,Juno Van Valkenburgh,Diana E Ingles et al.
Marlon Vincent V Duro et al.
Docosahexaenoic acid [22:6(n-3), DHA], a polyunsaturated fatty acid, has an important role in regulating neuronal functions and in normal brain development. Dysregulated brain DHA uptake and metabolism are found in individuals carrying the ...
Genome-Wide 5-Formylcytosine Redistribution in KCl-Stimulated Mouse Primary Cortical Neurons is Associated with Neuronal Activity [0.03%]
高氯酸刺激小鼠原发皮层神经元中5-醛基胞嘧啶的重分布与神经元活性相关性研究
Du Wu,Kaixin Huang,Jichun Shi et al.
Du Wu et al.
An abundant accumulation of DNA demethylation intermediates has been identified in mammalian neurons. While the roles of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in neuronal function have been extensively studied, little is...
Techniques for Measurement of Serotonin: Implications in Neuropsychiatric Disorders and Advances in Absolute Value Recording Methods [0.03%]
血清素测量技术在神经精神疾病中的应用及绝对值记录方法的进展
Juan M Rojas Cabrera,Tyler S Oesterle,Aaron E Rusheen et al.
Juan M Rojas Cabrera et al.
Serotonin (5-HT) is a monoamine neurotransmitter in the peripheral, enteric, and central nervous systems (CNS). Within the CNS, serotonin is principally involved in mood regulation and reward-seeking behaviors. It is a critical regulator in...
Neuroinflammation-Modulating Agent SB1617 Enhances LC3-Associated Phagocytosis to Mitigate Tau Pathology [0.03%]
调控神经炎症的药物SB1617通过促进LC3相关吞噬作用缓解tau蛋白病理损害
Hana Cho,Bo Young Choi,Young-Hee Shin et al.
Hana Cho et al.
Tau protein aggregation and propagation in neurons and surrounding microglia are well-known risk factors for neurodegenerative diseases. Therefore, emerging therapeutic strategies that target neuroinflammatory activity in microglia have the...
Design and Characterization of Prodrug-like Inhibitors for Preventing Glutamate Efflux through Reverse Transport [0.03%]
设计和表征谷氨酸反向转运脱药剂以预防谷氨酸释放
Laura J Zielewicz,Jiali Wang,Elias Ndaru et al.
Laura J Zielewicz et al.
Glutamate transporters are responsible for active transport of the major excitatory neurotransmitter glutamate across the cell membrane, regulating the extracellular glutamate concentration in the mammalian brain. Extracellular glutamate le...
Heterotypic Interactions between the 40- and 42-Residue Isoforms of β-Amyloid Peptides on Lipid Bilayer Surfaces [0.03%]
β淀粉样肽40和42亚型在脂质双层膜上的异相相互作用
Wei Qiang,Maurine K Kengwerere,Wancheng Zhao et al.
Wei Qiang et al.
Co-aggregation involving different amyloidogenic sequences has been emphasized recently in the modified amyloid cascade hypothesis. Yet, molecular-level interactions between two predominant β-amyloid peptide sequences, Aβ40 and Aβ42, in ...