Synthesis, Labeling, and Biological Evaluation of P2Y12 Receptor Radioligands for Positron Emission Tomography Imaging of Neuroinflammation [0.03%]
用于正电子发射断层扫描成像的小胶质细胞活化P2Y12受体放射性配体的合成、标记和生物评价
Eugénie Pincemail,Marie-Anne Peyronneau,Caroline Denis et al.
Eugénie Pincemail et al.
The P2Y12 receptor (P2Y12R) is a G-protein-coupled receptor whose expression level is directly correlated to microglial activation. Herein, we report on the design of a series of new P2Y12R ligands and the radiolabeling and characterization...
Donald F Weaver
Donald F Weaver
Machine Learning Model for Predicting Sertraline-like Activities and Its Impact on Cancer Chemosensitization [0.03%]
一种预测舍曲林类药物活性及其对癌症化疗增敏作用影响的机器学习模型
Jin-Yu Xia,Ze-Yu Sun,Ying Xue et al.
Jin-Yu Xia et al.
Selective serotonin reuptake inhibitors (SSRIs) like sertraline are crucial in treating depression and anxiety disorders, and studies indicate their potential as chemosensitizers in cancer therapy. This research develops a machine-learning ...
Restoring Brain Function in Autism: GSK3β Inhibition by 6-Bromoindirubin-3'-oxime Reverses Valproic Acid-induced Neuropathology [0.03%]
6-溴靛红-3'-肟通过抑制GSK3β改善自闭症小鼠大脑功能和行为缺陷
Ashish Jain,Neha Dhir,Praisy K Prabha et al.
Ashish Jain et al.
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social deficits, restricted interests, and repetitive behaviors. Although aripiprazole and risperidone are FDA-approved for ASD, they primarily target...
Estimation of Dopamine D1 Receptor Agonist Binding Kinetics Using Time-Resolved Functional Assays: Relation to Agonist-Induced Receptor Internalization by Investigational Antiparkinsonian Therapeutics [0.03%]
时间分辨功能测定法测量多巴胺D1受体激动剂结合动力学及其与实验性抗帕金森病药物诱导的受体内吞作用的关系研究
Kristoffer Sahlholm,Peder Svensson,Marcus Malo et al.
Kristoffer Sahlholm et al.
The dopamine D1 receptor (D1R) is prominently expressed in the striatum and cerebral cortex and is an attractive target for treating Parkinson's disease and cognitive impairment in schizophrenia. While newer, noncatechol D1R agonists such a...
Targeting Acetylcholinesterase with Oxytocin: A New Avenue in Alzheimer's Disease Therapeutics [0.03%]
催产素靶向乙酰胆碱酯酶：阿尔茨海默病治疗的新途径
Chhanda Charan Danta,Prakash Chaudhari,Adel Nefzi
Chhanda Charan Danta
Oxytocin, the so-called natural love hormone, is a neuropeptide comprising nine amino acids with an active aliphatic disulfide bond forming the cyclic ring through cysteine1-cysteine6 residues. Oxytocin synthesizes in hypothalamus and acts ...
Neuroprotective Effects of a Benzofuran-Containing Selenium in a Mouse Alzheimer's Disease Model: Molecular, Biochemical, and Behavioral Analyses [0.03%]
含硒苯并呋喃类化合物的神经保护作用：基于小鼠阿尔茨海默病模型的行为学、生化及分子机制研究
Tácia Katiane Hall,Mariana Parron Paim,Pâmella da Costa et al.
Tácia Katiane Hall et al.
Alzheimer's disease (AD) is a neurodegenerative disorder mainly characterized by progressive cognitive decline, for which effective treatments remain limited, and selenium is known for its neuroprotective actions. Thus, this study evaluated...
Unraveling the Role of THRIL/miR-137 in Fine-Tuning the Immunological Transcriptional Loop STAT4/STAT6/GATA3 in Multiple Sclerosis: Implications on Neurological Complications and Disease Subtypes [0.03%]
探究THRIL/miR-137在多发性硬化免疫转录环STAT4/STAT6/GATA3精细调节中的作用：对神经并发症和疾病亚型的启示
Ghada Ayeldeen,Bahaa Mohammed Badr,Aeshah A Awaji et al.
Ghada Ayeldeen et al.
Multiple sclerosis (MS) is an autoimmune disease associated with neurological impairments. The study aimed to evaluate the role of the noncoding RNAs THRIL/miR-137 in MS pathogenesis via studying their effect on the immunological transcript...
Correction to "Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound" [0.03%]
“ONO-2920632(VU6011887)的发现：一种高选择性且进入中枢神经系统的TREK-2(TWIK相关钾通道2)偏向激活剂在体工具化合物”的勘误通知
Kentaro Yashiro,Yuzo Iwaki,Hirohito Urata et al.
Kentaro Yashiro et al.
Published Erratum
ACS chemical neuroscience. 2025 Jun 16. DOI:10.1021/acschemneuro.5c00409 2025
Modulation of hIAPP Fibrillation by Rationally Designed Hexapeptides Revealed by Molecular Dynamics and Experimental Investigations [0.03%]
分子动力学和实验研究揭示了理性设计的六肽对人IAPP纤维化的作用
Diksha Rani,Nitesh Priyadarshi,Nitin Kumar Singhal et al.
Diksha Rani et al.
The misfolding and aggregation of 37-residue neuropancreatic hormone hIAPP (human islet amyloid polypeptide) to cytotoxic aggregates comprising oligomers, protofibrils, and mature fibrils have been linked to the pathogenesis of T2D (type 2 ...