Modulation of hIAPP Fibrillation by Rationally Designed Hexapeptides Revealed by Molecular Dynamics and Experimental Investigations
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The misfolding and aggregation of 37-residue neuropancreatic hormone hIAPP (human islet amyloid polypeptide) to cytotoxic aggregates comprising oligomers, protofibrils, and mature fibrils have been linked to the pathogenesis of T2D (type 2 diabetes). Scrocchi ... ...
