A Small Molecule Impedes the Aβ1-42 Tetramer Neurotoxicity by Preserving Membrane Integrity: Microsecond Multiscale Simulations [0.03%]
一种小分子通过维持膜稳定性来阻碍Aβ1-42四聚体神经毒性：微秒多尺度模拟研究
Subramanian Boopathi,Ramón Garduño-Juárez
Subramanian Boopathi
Amyloid-β (Aβ1-42) peptides aggregated into plaques deposited in the brain are the main hallmark of Alzheimer's disease (AD), a social and economic burden worldwide. In this context, insoluble Aβ1-42 fibrils are the main components of pl...
EphA4 Targeting Peptide-Conjugated Extracellular Vesicles Rejuvenates Adult Neural Stem Cells and Exerts Therapeutic Benefits in Aging Rats [0.03%]
靶向 EphA4 多肽的外泌体可改善老年大鼠神经干细胞功能及发挥治疗效应
Satyajit Ghosh,Rajsekhar Roy,Nabanita Mukherjee et al.
Satyajit Ghosh et al.
Aging and various neurodegenerative diseases cause significant reduction in adult neurogenesis and simultaneous increase in quiescent neural stem cells (NSCs), which impact the brain's regenerative capabilities. To deal with this challengin...
A Multimodal, In Vivo Approach for Assessing Structurally and Phenotypically Related Neuroactive Molecules [0.03%]
一种评估结构和表型相关神经活性分子的多模态、体内方法
Matthew N McCarroll,Elizabeth Sisko,Jung Ho Gong et al.
Matthew N McCarroll et al.
A recently reported behavioral screen in larval zebrafish for phenocopiers of known anesthetics and associated drugs yielded an isoflavone. Related isoflavones have also been reported as GABAA potentiators. From this, we synthesized a small...
Synthesis and Evaluation of 18F-Labeled Phenylpiperazine-like Dopamine D3 Receptor Radioligands for Positron Emission Tomography Imaging [0.03%]
用于正电子发射断层显像的苯基哌嗪类多巴胺D3受体放射性配体的合成与评价
Ge Zhang,Shilun Zhao,Zuoquan Zhao et al.
Ge Zhang et al.
The dopamine D3 receptor (D3R) is important in the pathophysiology of various neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, drug addiction, and Parkinson's disease. Positron emission tomography (PET) with ...
Automated, Transferable, and Ethanol-Free Radiosynthesis of [11C]Butanol [0.03%]
自动化、可转移且无需乙醇的[11C]丁醇放射合成法
Olujide Oyeniran,Linshan Liu,Confidence Raymond et al.
Olujide Oyeniran et al.
Cerebral blood flow and blood-brain barrier permeability assessment are crucial hemodynamic parameters to measure under neurological conditions. In conjunction with positron emission tomography (PET), oxygen-15-labeled water has emerged as ...
Saroglitazar Enhances Memory Functions and Adult Neurogenesis via Up-Regulation of Wnt/β Catenin Signaling in the Rat Model of Dementia [0.03%]
萨羅利扎特改善痴呆模型大鼠记忆功能及促进成体神经发生的作用及其对Wnt/β-catenin信号通路的上调作用研究
Sandeep Kumar Mishra,Vaibhav Mishra
Sandeep Kumar Mishra
Peroxisome proliferator-activated receptors (PPARs) have emerged as a promising target for the treatment of various neurodegenerative disorders. Studies have shown that both PPAR α & γ individually modulate various pathophysiological even...
Bifunctional Inhibitor Lentinan Inhibits Fibrillogenesis of Amyloid-β Protein and α-Synuclein and Alleviates Their Cytotoxicity: In Vitro and In Vivo Studies [0.03%]
香菇多糖抑制淀粉样蛋白和α-突触核蛋白纤维形成及毒性作用的体内外研究
Wen Gao,Qinchen Dong,Xinni Wu et al.
Wen Gao et al.
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative diseases in the world. Misfolding of β-amyloid (Aβ) and α-synuclein (α-syn) and subsequent fibril formation are closely associated with the ...
The Antiproteinopathy, Antioxidant, and Antiapoptotic Effects of Methylene Blue and 4-Phenylbutyric Acid Alone, and in Combination on Familial Alzheimer's Disease PSEN1 I416T Cholinergic-Like Neurons [0.03%]
甲基蓝和4-苯丁酸及其联用对家族性阿尔茨海默病PSEN1 I416T胆碱能样神经元的抗蛋白opathy，抗氧化及抗凋亡作用
Nicolas Gomez-Sequeda,Marlene Jimenez-Del-Rio,Carlos Velez-Pardo
Nicolas Gomez-Sequeda
Familial Alzheimer's disease (FAD) is a chronic neurological condition that progresses over time. Currently, lacking a viable treatment, the use of multitarget medication combinations has generated interest as a potential FAD therapy approa...
Diego Rivera-Illanes,Gonzalo Recabarren-Gajardo
Diego Rivera-Illanes
Muscimol (3) is a psychoactive isoxazole present in various Amanita mushrooms, along with ibotenic acid and muscarine. It is structurally related to GABA and acts as a GABAA agonist with great affinity. Muscimol use dates back to Siberian s...
Reversible Control of Native GluN2B-Containing NMDA Receptors with Visible Light [0.03%]
用可见光可逆控制原生GluN2B-NMDA受体
Chloé Geoffroy,Romain Berraud-Pache,Nicolas Chéron et al.
Chloé Geoffroy et al.
NMDA receptors (NMDARs) are glutamate-gated ion channels playing a central role in synaptic transmission and plasticity. NMDAR dysregulation is linked to various neuropsychiatric disorders. This is particularly true for GluN2B-containing NM...