Unveiling the Human Brain on a Chip: An Odyssey to Reconstitute Neuronal Ensembles and Explore Plausible Applications in Neuroscience [0.03%]
揭开芯片上的神秘人类大脑：重组神经元簇的可能性及在神经科学中的应用探索
Subhadra Nandi,Satyajit Ghosh,Shubham Garg et al.
Subhadra Nandi et al.
The brain is an incredibly complex structure that consists of millions of neural networks. In developmental and cellular neuroscience, probing the highly complex dynamics of the brain remains a challenge. Furthermore, deciphering how severa...
Evaluation of Alpha-Synuclein and Tau Antiaggregation Activity of Urea and Thiourea-Based Small Molecules for Neurodegenerative Disease Therapeutics [0.03%]
用于神经退行性疾病治疗的脲和硫脲衍生物小分子抗聚集活性评估
Susantha K Ganegamage,Taiwo A Ademoye,Henika Patel et al.
Susantha K Ganegamage et al.
Alzheimer's disease (AD) and Parkinson's disease (PD) are multifactorial, chronic diseases involving neurodegeneration. According to recent studies, it is hypothesized that the intraneuronal and postsynaptic accumulation of misfolded protei...
The Importance of Stereochemistry in 5-HT7R Modulation─A Case Study of Hydantoin Derivatives [0.03%]
stereochemistry在5-HT7R调节中的重要性─氢化物衍生物的案例研究
Katarzyna Kucwaj-Brysz,Sebastian Baś,Ewa Żesławska et al.
Katarzyna Kucwaj-Brysz et al.
Serotonin 5-HT7 receptor (5-HT7R), one of the most recently discovered members of the serotonergic system, has become a promising target in the search for central nervous system disorders. Despite the number of preclinical results, none of ...
Debsankar Saha Roy,Ankit Singh,Vidita A Vaidya et al.
Debsankar Saha Roy et al.
Serotonergic psychedelics, known for their hallucinogenic effects, have attracted interest due to their ability to enhance neuronal plasticity and potential therapeutic benefits. Although psychedelic-enhanced neuroplasticity is believed to ...
Rational Search for Betaine/GABA Transporter 1 Inhibitors─ In Vitro Evaluation of Selected Hit Compound [0.03%]
胆碱/γ-氨基丁酸转运体1抑制剂的理性筛选及所选活性化合物的体内评价
Kamil Łątka,Stefanie Kickinger,Zuzanna Rzepka et al.
Kamil Łątka et al.
Inhibitory neurotransmission mediated by γ-aminobutyric acid (GABA) plays an important role in maintaining body homeostasis. Disturbances in GABA signaling are implicated in a multitude of neurologic and psychiatric conditions, including e...
Exogenous Amyloid Fibrils Can Cause Significant Upregulation of Neurodegenerative Disease Proteins [0.03%]
外源淀粉样纤维可引起神经退行性疾病相关蛋白显著上调
Xihua Liu,Wenzhe Jia,Yapeng Fang et al.
Xihua Liu et al.
Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are associated with the formation of amyloid fibrils. In familial cases, the mutant causative genes accentuate disease progression through overexpression or mi...
Imaging Glucose Metabolism and Dopaminergic Dysfunction in Sheep (Ovis aries) Brain Using Positron Emission Tomography Imaging Reveals Abnormalities in OVT73 Huntington's Disease Sheep [0.03%]
正电子发射断层扫描成像技术在羊脑中葡萄糖代谢和多巴胺功能紊乱及OVTL15亨廷顿舞蹈病羊异常的研究
Georgia K Williams,Jordy Akkermans,Matt Lawson et al.
Georgia K Williams et al.
Huntington's disease (HD) is a neurodegenerative disease that causes cognitive, movement, behavioral, and sleep disturbances, which over time result in progressive disability and eventually death. Clinical translation of novel therapeutics ...
Pedro de Andrade Horn,Tomayo I Berida,Lauren C Parr et al.
Pedro de Andrade Horn et al.
Medetomidine is an FDA-approved α2-adrenoreceptor (α2-AR) agonist used as a veterinary sedative due to its analgesic, sedative, and anxiolytic properties. While it is marketed for veterinary use as a racemic mixture under the brand name D...
Maria O Nerush,Vadim A Shevyrin,Nikita I Golushko et al.
Maria O Nerush et al.
Antihistaminic drugs are widely used clinically and have long been primarily known for their use to treat severe allergic conditions caused by histamine release. Antihistaminic drugs also exert central nervous system (CNS) effects, acting a...
Bile Acids as Modulators of α-Synuclein Aggregation: Implications for Parkinson's Therapy [0.03%]
胆酸作为α-突触核蛋白聚集的调节剂：对帕金森病治疗的意义
Harpreet Kaur,Devansh Swadia,Sharmistha Sinha
Harpreet Kaur
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the aggregation of α-synuclein into toxic amyloid fibrils. Recent research suggests that bile acids altered in PD may influence their aggregation. This study investi...