Ultrasensitive Detection of Attomolar Neurofilament Light Chain Using Gold Nanoparticle-Assisted CRISPR-Cas12a Enhanced Fluorescent Assay [0.03%]
利用金纳米粒子增强的CRISPR-Cas12a荧光试纸条检测飞摩尔神经丝轻链蛋白
Rana Jahani,Sathishkumar Munusamy,Haiyan Zheng et al.
Rana Jahani et al.
Neurofilament light chain (NfL) is a nonspecific biomarker that can indicate neuronal damage, and elevated NfL levels have been reported in several neurological disorders and traumatic brain injury and are correlated with disease severity a...
COG1410 Alleviated Chronic Sleep Deprivation-Induced Memory Loss by Regulating Microglial Phagocytosis and Inhibiting Hippocampal Inflammation [0.03%]
COG1410通过调节小胶质细胞吞噬作用和抑制海马炎症来缓解慢性睡眠剥夺引起的记忆丧失
Peng Wu,Chao Fu,Min Chen et al.
Peng Wu et al.
It is widely recognized that sleep loss harms healthy adults. Microglia-mediated synaptic pruning is active during sleep and contributes to memory consolidation. Here, we established a mouse model of sleep deprivation (SD) using a modified ...
The Functional Topology of Phenylpiperazinium Agonists and Antagonists on the Nicotinic Acetylcholine Receptor Landscape: Pointing the Way for Future Therapeutic Management of Inflammation and Neuropathic Pain [0.03%]
尼古丁乙酰胆碱受体景观上苯哌嗪激动剂和拮抗剂的功能拓扑结构：为未来治疗炎症和神经性疼痛指明方向
Hina Andleeb,Alican Gulsevin,Roger L Papke
Hina Andleeb
The ganglionic blocker 1,1-dimethyl-4-phenylpiperazinium (diMPP) has agonist activity on a variety of neuronal nicotinic acetylcholine receptors (nAChRs). Recently, the related compound 1,1-diethyl-4-phenylpiperazinium (diEPP) has been used...
Stanley A Buczynski,Amy Li,Janie Chang-Weinberg et al.
Stanley A Buczynski et al.
Photoactivatable neurotransmitters provide spatiotemporally precise experimenter control over endogenous receptor activation in living tissue. The resulting optical stimulus-neuronal response relationship provides a sensitive assay that can...
Phosphoproteomics Profiling Reveals Key Proteins Involved in Neuroinflammation and Impaired Axon Guidance Induced by Bilirubin Deficiency [0.03%]
磷酸蛋白质组学揭示了胆红素缺乏诱导神经炎症和轴突导向障碍相关的关键蛋白
Ming Chen,Cuiping Wu,Yaqi Cui et al.
Ming Chen et al.
Hypobilirubinemia, characterized by low bilirubin levels, is increasingly recognized as a pathological condition linked to various neurodevelopmental and neurodegenerative diseases. However, the neuropathological mechanisms of hypobilirubin...
Dual Inhibition of IDO1 and TDO: A Unified Therapeutic Strategy to Combat Alzheimer's Disease and Cancer [0.03%]
IDO1和TDO的双重抑制：对抗阿尔茨海默病和癌症的统一治疗策略
Arpita Robel Khamle,Saroj Kumar Panda,Varshini Dayanand Kore et al.
Arpita Robel Khamle et al.
The kynurenine pathway, regulated by the enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO), plays a pivotal role in immune regulation and neuroinflammation in human. Dysregulation of this pathway has been str...
A New Class of Vitamin K Analogues Containing the Side Chain of Retinoic Acid Have Enhanced Activity for Inducing Neuronal Differentiation [0.03%]
一类含有视黄酸侧链的维生素K类似物能够增强诱导神经细胞分化作用
Yoshihisa Hirota,Taiki Sato,Rina Watanabe et al.
Yoshihisa Hirota et al.
Vitamin K, primarily known for its roles in coagulation and bone metabolism, has recently been implicated in neuroprotection and neuronal differentiation, particularly via its bioactive form, menaquinone-4 (MK-4). Here, we synthesized 12 vi...
Impact of Lysine Acetylation Mutations on the Structure of Full-Length Tau Fibrils [0.03%]
赖氨酸乙酰化突变对全长tau原纤维结构的影响
Aurelio J Dregni,Mei Hong
Aurelio J Dregni
The tau protein aggregates into amyloid fibrils in Alzheimer's disease and other neurodegenerative diseases. In these tauopathies, tau is decorated with posttranslational modifications, including phosphorylation and acetylation, suggesting ...
The Association between Body Mass Index, HbA1c Levels, and Tarsal Tunnel Syndrome: A Clinical and Neurophysiological Study [0.03%]
BMI和HBA1C水平与跗管综合征的关联：临床及神经电生理研究
Marwa Hanafy Abo Omirah,Marwa Kamal,Mohammed Gomaa et al.
Marwa Hanafy Abo Omirah et al.
Tarsal Tunnel Syndrome (TTS) is a focal compressive entrapment neuropathy affecting the posterior tibial nerve. While obesity and diabetes mellitus are known as systemic risk factors, their specific impact on TTS severity remains insufficie...
Multimodal Neuroimaging for the PK/PD Profile of NLX-204: A Biased 5-HT1A Receptor Agonist [0.03%]
NLX-204表型的多模态神经影像学研究：偏向性5-HT1A受体激动剂
Violette Richin,Marco Valdebenito,Caroline Bouillot et al.
Violette Richin et al.
NLX-204, a highly selective biased agonist for serotonin 5-HT1A receptors, demonstrates strong affinity and preferentially elicits ERK1/2 phosphorylation, a response linked to antidepressant activity. Preclinical studies in rodent models co...