The Functional Topology of Phenylpiperazinium Agonists and Antagonists on the Nicotinic Acetylcholine Receptor Landscape: Pointing the Way for Future Therapeutic Management of Inflammation and Neuropathic Pain
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The ganglionic blocker 1,1-dimethyl-4-phenylpiperazinium (diMPP) has agonist activity on a variety of neuronal nicotinic acetylcholine receptors (nAChRs). Recently, the related compound 1,1-diethyl-4-phenylpiperazinium (diEPP) has been used as a scaffold for t... ...
