Effect of a SARS-CoV-2 Protein Fragment on the Amyloidogenic Propensity of Human Islet Amyloid Polypeptide [0.03%]
SARS-CoV-2蛋白片段对人胰岛淀粉样多肽淀粉样性质的影响
Marvin Bilog,Jennifer Cersosimo,Iliana Vigil et al.
Marvin Bilog et al.
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the onset of COVID-19 have been linked to an increased risk of developing type 2 diabetes. While a variety of mechanisms may ultimately be responsible for the o...
Evaluation of the Neuroprotective Effect of Total Glycosides of Cistanche deserticola and Investigation of Novel Brain-Targeting Natural MAO-B Inhibitors [0.03%]
肉苁蓉总苷的神经保护作用评估及新型脑靶向天然MAO-B抑制剂的发现研究
Xinyuan Zhai,Wenyu Xie,Muhammad Danish Yaqoob et al.
Xinyuan Zhai et al.
In this study, we investigated the role of total glycosides of Cistanche deserticola (TC) in MPTP-induced neuronal injury. Further, we screened potential inhibitory components of monoamine oxidase B (MAO-B). The study results indicate that ...
Damage of the Phospholipid Bilayer by Aβ42 at Physiologically Relevant Peptide Concentrations [0.03%]
Aβ42生理浓度下对磷脂双分子层的破坏作用
Ruan van Deventer,Yuri L Lyubchenko
Ruan van Deventer
Amyloid β (Aβ) aggregates are implicated in the pathology of several neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, and Parkinson's disease, and damage to membranes is considered one of the pathology-related...
Stereospecific Properties and Intracellular Transport of Novel Intrinsically Fluorescent Neurosteroids [0.03%]
新型固有荧光神经甾体的立体异构特性和胞内转运
Vibeke Akkerman,Peter Reinholdt,Rasmus Schnoor-Madsen et al.
Vibeke Akkerman et al.
Allopregnanolone (AlloP) is an example of neuroactive steroids (NAS), which is a potent allosteric activator of the γ-aminobutyric acid A (GABAA) receptor. The mechanisms underlying the biological activity of AlloP and other NAS are only p...
Cross-Interactions of Aβ Peptides Implicated in Alzheimer's Disease Shape Amyloid Oligomer Structures and Aggregation [0.03%]
与阿尔茨海默病相关的Aβ肽的交叉相互作用塑造淀粉样寡聚体结构和聚集性
Tanja Habeck,Silvana Smilla Zurmühl,António J Figueira et al.
Tanja Habeck et al.
A defining hallmark of Alzheimer's disease (AD) is the synaptic aggregation of the amyloid β (Aβ) peptide. In vivo, Aβ production results in a diverse mixture of variants, of which Aβ40, Aβ42, and Aβ43 are profusely present in the AD ...
Pathological Mutations D169G and P112H Electrostatically Aggravate the Amyloidogenicity of the Functional Domain of TDP-43 [0.03%]
病理突变D169G和P112H通过静电效应加剧TDP-43功能性结构域淀粉样蛋白的形成
Meenakshi Pillai,Anjali D Patil,Atanu Das et al.
Meenakshi Pillai et al.
Aggregation of TDP-43 is linked to the pathogenesis of many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Notably, electrostatic point mutations such as D169G and P112H, located within the highly conserved funct...
Emerging Frontiers in Conformational Exploration of Disordered Proteins: Integrating Autoencoder and Molecular Simulations [0.03%]
无序蛋白构象探索新进展：自编码器与分子模拟的融合
Jiyuan Zeng,Zhongyuan Yang,Yiming Tang et al.
Jiyuan Zeng et al.
Intrinsically disordered proteins (IDPs) are closely associated with a number of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Due to the highly dynamic nature of IDPs, their structural determination and c...
Deciphering the Monomeric and Dimeric Conformational Landscapes of the Full-Length TDP-43 and the Impact of the C-Terminal Domain [0.03%]
全长TDP-43单体和二聚体构象景观的解密及其C末端结构域的影响
Vaishnavi Tammara,Abhilasha A Doke,Santosh Kumar Jha et al.
Vaishnavi Tammara et al.
The aberrant aggregation of TAR DNA-binding protein 43 kDa (TDP-43) in cells leads to the pathogenesis of multiple fatal neurodegenerative diseases. Decoding the proposed initial transition between its functional dimeric and aggregation-pro...
Discovery of the First-in-Class Dual TSPO/Carbonic Anhydrase Modulators with Promising Neurotrophic Activity [0.03%]
一类双重TSPO/碳酸酐酶调节剂的发现及其潜在的神经保护活性
Valeria Poggetti,Elisa Angeloni,Lorenzo Germelli et al.
Valeria Poggetti et al.
In searching for putative new therapeutic strategies to treat neurodegenerative diseases, the mitochondrial 18 kDa translocator protein (TSPO) and cerebral isoforms of carbonic anhydrase (CA) were exploited as potential targets. Based on th...
Rimota-Gd: Paramagnetic Probe for In Vivo MRI Studies of the Cannabinoid 1 Receptor Distribution in the Mouse Brain [0.03%]
脑磁共振成像小鼠脑内源性大麻素受体1分布的顺磁性探针Rimowa-Gd的研究
Qi Ouyang,Fei Zhao,Jingjing Ye et al.
Qi Ouyang et al.
The cannabinoid 1 receptor (CB1) is highly expressed in the central nervous system, where its physiological functions include the regulation of energy balance, pain, and addiction. Herein, we develop and validate a technique to use magnetic...