Selection of DNA Aptamers That Promote Neurite Outgrowth in Human iPSC-Derived Sensory Neuron Organoid Cultures [0.03%]
从人类iPSC衍生的感官神经器官培养物中促进神经生长的DNA适体的选择
Brandon Wilbanks,Jenelle Rolli,Keenan Pearson et al.
Brandon Wilbanks et al.
Sensory neurons in the dorsal root ganglia transmit sensory signals from the periphery to the central nervous system. Induced pluripotent stem cell derived models of sensory neurons and dorsal root ganglia are among the most advanced availa...
Snake Venom-Inspired Novel Peptides Protect Caenorhabditis elegans against Paraquat-Induced Parkinson's Pathology [0.03%]
受蛇毒启发的新多肽可保护秀丽隐杆线虫免受百草枯诱导的帕金森病理损伤
Dev Madhubala,Rosy Mahato,Kangkon Saikia et al.
Dev Madhubala et al.
The in vivo protective mechanisms of two low-molecular-mass (∼1.4 kDa) novel custom peptides (CPs) against paraquat-induced neurodegenerative dysfunction in the Caenorhabditis elegans model were deciphered. CPs prevented the paraquat from ...
Identification and Characterization of the Structure and Size of Aβ42 Oligomers Targeting the Receptor FcγRIIb [0.03%]
Aβ42寡聚体识别和特征分析及其与受体FcγRIIb相互作用的结构和大小研究
Mengke Jia,Chuanbo Wang,Jinfei Mei et al.
Mengke Jia et al.
Kam and colleagues discovered that FcγRIIb can specifically bind to Aβ42 oligomers (AβOs). The N-terminal residues F4 and D7 of Aβ42, as well as the W115 residue in domain D2 of FcγRIIb, are involved in this binding. However, the speci...
Exploring Human Brain Metabolism via Genome-Scale Metabolic Modeling with Highlights on Multiple Sclerosis [0.03%]
通过基因组规模代谢建模探索人体大脑代谢以及对多发性硬化症的研究Highlights on Multiple Sclerosis应翻译为“重点关注多发性硬化症”，但根据上下文，更合适的翻译可能是“以多发性硬化症为例”。因此，完整的翻译可以是：“通过基因组规模代谢建模探索人体大脑代谢并以多发性硬化症为例”为了简洁明了，建议最终标题如下：“基因组尺度代谢模型在人类脑代谢中的应用及其在多发性硬化症研究中的作用”
Mustafa Sertbas,Kutlu O Ulgen
Mustafa Sertbas
Cerebral dysfunctions give rise to a wide range of neurological diseases due to the structural and functional complexity of the human brain stemming from the interactive cellular metabolism of its specific cells, including neurons and glial...
Shengneng Chen,Ding Luo,Weiwei Xue
Shengneng Chen
Computational drug design is a rapidly evolving field, especially the latest breakthroughs in generative artificial intelligence (GenAI) to create new compounds. However, the potential of GenAI to address the challenges in designing central...
Evidence of α-Synuclein/Glucocerebrosidase Dual Targeting by Iminosugar Derivatives [0.03%]
羟基糖衍生物对α-突触核蛋白/葡糖脑苷脂酶双重靶点的证据研究
Giuseppe Tagliaferro,Maria Giulia Davighi,Francesca Clemente et al.
Giuseppe Tagliaferro et al.
Intrinsically disordered proteins (IDPs) are highly flexible molecules often linked to the onset of incurable diseases. Despite their great therapeutic potential, IDPs are often considered as undruggable because they lack defined binding po...
Comparative Radiotracing Quantifies Brain Cellular Uptake and Catabolism of Bispecific Antibodies Targeting Transferrin Receptor and CD98hc [0.03%]
比较放射追踪定量分析双特异性抗体靶向转铁蛋白受体和CD98hc的脑细胞摄取和代谢过程
Jacob L Veire,Michael J Lucas,Layne G Bond et al.
Jacob L Veire et al.
Bispecific antibodies (bAbs) that engage cerebrovascular targets, induce transport across the blood-brain barrier (BBB), and redistribute to secondary targets within the brain parenchyma have the potential to transform the diagnosis and tre...
A Brain-Penetrating Foldamer Rescues Aβ Aggregation-Associated Alzheimer's Disease Phenotypes in In Vivo Models [0.03%]
穿透脑部的折叠聚合物挽救了活体模型中与Aβ聚集相关的阿尔茨海默氏症表型
Charles Zuwu Baysah,Ryan A Dohoney,L Palanikumar et al.
Charles Zuwu Baysah et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is the leading cause of dementia, affecting nearly 55 million people across the world. One of the central pathological factors associated with AD is the aggregation o...
Neurochemical Assessment of Tissue Levels of Neurotransmitters for Approximating Neurotransmitter System Connectivity [0.03%]
通过测定组织中神经递质的水平来近似评估神经递传系统连接性
Jasmine Jade Butler,Chloé Aman,Marion Rivalan et al.
Jasmine Jade Butler et al.
The post-mortem measurement of tissue neurotransmitters is an interesting technique to address the gross biochemical activity. Its primary limitation is a lack of temporal resolution, although this is mitigated by enhanced spatial resolutio...
Exploring the Potential of Indole-3-acetic Acid Arylhydrazone Hybrids for Parkinson's Disease Treatment: A Comprehensive Evaluation of Neuroprotective, MAOB Inhibitory, and Antioxidant Properties [0.03%]
吲哚-3-乙酸芳基腙类似物在帕金森病治疗中的潜力探索：神经保护、单胺氧化酶B抑制和抗氧化特性的综合评估
Neda Anastassova,Magdalena Kondeva-Burdina,Nadya Hristova-Avakumova et al.
Neda Anastassova et al.
In the current study, a small series of five indole-3-acetic acid-derived arylhydrazone hybrids were synthesized and subjected to comprehensive evaluation of their neuropharmacological and radical-scavenging properties. Minimal neurotoxic e...