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Identification and Characterization of the Structure and Size of Aβ42 Oligomers Targeting the Receptor FcγRIIb

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Kam and colleagues discovered that FcγRIIb can specifically bind to Aβ42 oligomers (AβOs). The N-terminal residues F4 and D7 of Aβ42, as well as the W115 residue in domain D2 of FcγRIIb, are involved in this binding. However, the specificity of the FcγRI... ...