Safety and Efficacy of Allogeneic Integrin α10β1-Selected Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis: A First-In-Human Phase I/IIa Dose Escalation Study [0.03%]
人脐带间充质干细胞整合素α10β1分选治疗膝关节骨关节炎的I/IIa期剂量递增研究：安全性和有效性
Lucienne A Vonk,Camilla Wennersten,Kristina Uvebrant et al.
Lucienne A Vonk et al.
PurposeSafety and efficacy of allogeneic integrin α10β1-selected MSCs (integrin α10-MSCs) have been shown in two post-traumatic osteoarthritis (OA) equine models. The aim of this study is to evaluate safety, tolerability and preliminary ...
Distinct Reparative and Immunomodulatory Signatures of Extracellular Vesicles From Human Cartilage-Derived Chondroprogenitors, Chondrocytes, and Bone Marrow Mesenchymal Stem Cells in a Rat Osteoarthritis Model [0.03%]
人软骨谱系细胞来源的外泌体在膝关节炎模型中发挥不同的修复和免疫调节作用
Elizabeth Vinod,Ganesh Parasuraman,Abel Livingston et al.
Elizabeth Vinod et al.
BackgroundExtracellular vesicles (EVs) mediate many of the reparative effects of cell-based therapies for osteoarthritis; however, the influence of EV source on cartilage repair and systemic immune responses remains unclear. Cartilage-resid...
Effects of Compression on Extracellular Matrix Synthesis by Chondrocytes and Chondrosarcoma Cells [0.03%]
压缩对软骨细胞和软骨肉瘤细胞合成细胞外基质的影响
Carlo Alberto Paggi,Isa Porsul,Séverine Le Gac et al.
Carlo Alberto Paggi et al.
ObjectiveMechanical loading is critical for chondrocyte function and cartilage matrix production, yet its effects on clustered chondrocytes in end-stage osteoarthritis and on chondrosarcoma cells remain poorly understood. This study investi...
Sex and Age Affect Progression to Total Knee Arthroplasty After Cartilage Surgery: A UK Biobank Cohort Study [0.03%]
性别和年龄影响软骨手术后全膝关节置换术的发展：一项英国生物银行队列研究
Nicola J Kuiper,Charlotte H Hulme,Martyn Snow et al.
Nicola J Kuiper et al.
ObjectiveEvaluate the association of sex and age at surgery with time to total knee arthroplasty (TKA) following knee cartilage surgery in UK Biobank (UKB) participants.DesignParticipants with a history of knee cartilage surgery were classi...
In Vitro Cytotoxicity and Inflammatory Response of Local Anaesthetics and Corticosteroids in Canine Fibroblast-Like Synoviocytes [0.03%]
局部麻醉药和皮质类固醇犬滑膜样成纤维细胞的体外细胞毒性和炎症反应
Catarina Sousa,Ana Lima,Adriana Belas et al.
Catarina Sousa et al.
ObjectiveThis study investigated the dose-dependent cytotoxicity and immunomodulatory effects of intra-articular local anaesthetics (lidocaine, mepivacaine, levobupivacaine) and corticosteroids (dexamethasone, methylprednisolone, methylpred...
Exosomal LINC01106 From PRP-Treated ADSCs Alleviates Chondrocyte Inflammatory Injury by Sponging miR-34a-5p to Upregulate SIRT1 Expression [0.03%]
富血小板血浆处理的间充质干细胞源外泌体通过海绵吸附miR-34a-5p上调SIRT1表达来缓解软骨细胞炎症损伤
Xuan Zhang,Wentao Liu,Jinke Ren et al.
Xuan Zhang et al.
ObjectiveOsteoarthritis (OA) is characterized by progressive cartilage degeneration driven by inflammation-induced chondrocyte injury, while effective disease-modifying therapies are still lacking. Exosome-based cell-free approaches are eme...
Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection [0.03%]
基于纤连蛋白的选择后的人诱导软骨细胞（hiCHO）和人原代关节软骨细胞（hAC）的软骨质量比较评估
Giorgia Mazzini,Margo Tuerlings,Vicki van der Stap et al.
Giorgia Mazzini et al.
BackgroundCell-based cartilage repair is limited by loss of chondrogenic potential during in vitro expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on ...
Return to Work after Surgical Treatment of Osteochondral Defects of the Talus: A Systematic Review and Meta-Analysis [0.03%]
距骨骨软骨缺损手术治疗后重返工作岗位的系统评价和 meta 分析
Kaj S Emanuel,Sophia van Beelen,Jari Dahmen et al.
Kaj S Emanuel et al.
IntroductionReturn to work (RTW) is a key goal for patients treated for osteochondral lesions of the talus (OLT).AimThe primary objective of this review is to determine the RTW after surgical treatment of an OLT.MethodsAfter preregistration...
Hyperbaric Oxygen Therapy Improves Subchondral Perfusion and Cartilage Integrity in Established Osteoarthritis: A Pharmacokinetic DCE-MRI and T2* Quantification Study [0.03%]
有关于高压氧治疗改善软骨下血管生成和软骨完整性的研究：采用药代动力学DCE-MRI和T2 *定量研究成熟期骨关节炎模型中的渗透压及含水量变化
Guo-Shu Huang,Shih-Wei Chiang,Chiao-Chi Chen et al.
Guo-Shu Huang et al.
ObjectiveThis study investigated whether hyperbaric oxygen (HBO) therapy, initiated after disease establishment, exerts disease-modifying effects in a rat model of anterior cruciate ligament transection (ACLT)-induced post-traumatic osteoar...
Proteomics Analysis Reveals Serum Biomarkers Reflecting Joint Pain and Physical Limitations in Knee Osteoarthritis Before and After Joint Replacement Surgery [0.03%]
蛋白质组分析揭示了膝关节骨关节炎患者术前术后反映关节疼痛和身体机能限制的血清生物标志物
Anne-Mari Mustonen,Janne Tampio,Kristiina M Huttunen et al.
Anne-Mari Mustonen et al.
ObjectiveOsteoarthritis (OA) is an age-related musculoskeletal disorder lacking effective disease-modifying therapies and early diagnostic biomarkers. This study aimed to identify serum proteins that could indicate the occurrence of knee OA...