Davey M Smith,Jolie R Schafer,Brian Tullius et al.
Davey M Smith et al.
Natural killer (NK) cell-based immunotherapy is being explored for treating infectious diseases, including viral infections. Here, we discuss evidence of NK cell responses to different viruses, ongoing clinical efforts to treat such infecti...
Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation [0.03%]
降低的五羟色胺转运蛋白活性在二尖瓣处导致退行性二尖瓣反流的发展
Estibaliz Castillero,Emmett Fitzpatrick,Samuel J Keeney et al.
Estibaliz Castillero et al.
Degenerative mitral valve (MV) regurgitation (MR) is a highly prevalent heart disease that requires surgery in severe cases. Here, we show that a decrease in the activity of the serotonin transporter (SERT) accelerates MV remodeling and pro...
Bifunctional cancer cell-based vaccine concomitantly drives direct tumor killing and antitumor immunity [0.03%]
双功能癌症细胞疫苗可同时驱动直接的肿瘤杀伤和抗肿瘤免疫反应
Kok-Siong Chen,Clemens Reinshagen,Thijs A Van Schaik et al.
Kok-Siong Chen et al.
The administration of inactivated tumor cells is known to induce a potent antitumor immune response; however, the efficacy of such an approach is limited by its inability to kill tumor cells before inducing the immune responses. Unlike inac...
Activation of MAP2K signaling by genetic engineering or HF-rTMS promotes corticospinal axon sprouting and functional regeneration [0.03%]
通过基因工程或HF-rTMS激活MAP2K信号促进皮质脊髓轴突的萌发和功能性再生
Francesco Boato,Xiaofei Guan,Yanjie Zhu et al.
Francesco Boato et al.
Facilitating axon regeneration in the injured central nervous system remains a challenging task. RAF-MAP2K signaling plays a key role in axon elongation during nervous system development. Here, we show that conditional expression of a const...
Assessment of systemic AAV-microdystrophin gene therapy in the GRMD model of Duchenne muscular dystrophy [0.03%]
GRMD模型中系统性AAV-微小营养不良基因治疗的评估
Sharla M Birch,Michael W Lawlor,Thomas J Conlon et al.
Sharla M Birch et al.
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease caused by the absence of dystrophin, a membrane-stabilizing protein encoded by the DMD gene. Although mouse models of DMD provide insight into the potential of a corr...
Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis [0.03%]
ALDH1A2基因变异揭示维甲酸的抗炎作用及骨关节炎一类新的疾病改善药物
Linyi Zhu,Pragash Kamalathevan,Lada A Koneva et al.
Linyi Zhu et al.
More than 40% of individuals will develop osteoarthritis (OA) during their lifetime, yet there are currently no licensed disease-modifying treatments for this disabling condition. Common polymorphic variants in ALDH1A2, which encodes the ke...
Mark E Peeples
Mark E Peeples
In clinical trials, RSV prefusion F protein induced higher neutralizing antibodies and more activated memory B cells than postfusion F protein (Chang et al.).
Persistent post-COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium [0.03%]
持续的新冠嗅觉丧失与嗅粘膜免疫细胞浸润和基因表达改变相关
John B Finlay,David H Brann,Ralph Abi Hachem et al.
John B Finlay et al.
SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. Although animal and ...
Mitochondrial augmentation of hematopoietic stem cells in children with single large-scale mitochondrial DNA deletion syndromes [0.03%]
线粒体DNA大片段缺失综合征儿童的造血干细胞的线粒体增强效应
Elad Jacoby,Omer Bar-Yosef,Noah Gruber et al.
Elad Jacoby et al.
Patients with single large-scale mitochondrial DNA (mtDNA) deletion syndromes (SLSMDs) usually present with multisystemic disease, either as Pearson syndrome in early childhood or as Kearns-Sayre syndrome later in life. No disease-modifying...
A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine [0.03%]
前融合稳定型RSV F亚单元疫苗诱导的B细胞反应比后融合F疫苗具有更广和更强的反应
Lauren A Chang,Emily Phung,Michelle C Crank et al.
Lauren A Chang et al.
There is currently no licensed vaccine for respiratory syncytial virus (RSV). Here, we assess the effect of RSV fusion protein (F) conformation on B cell responses in a post hoc comparison of samples from the DS-Cav1 [prefusion (pre-F)] and...