FXR adapts hepatic mitochondrial function to increased substrate oxidation in patients with obesity [0.03%]
法尼醇X受体通过增加底物氧化适应肥胖患者肝脏线粒体功能
Katrin Panzitt,Emilian Jungwirth,Lena E Vosko et al.
Katrin Panzitt et al.
Metabolic pressure shifts signaling pathways of nuclear receptors, including the bile acid receptor FXR, which are sensitive to nutritional inputs. We performed an FXR ChIP-seq-centered multiomic analysis of liver biopsy samples from indivi...
Engraftment and persistence of HBB base-edited hematopoietic stem cells in nonhuman primates [0.03%]
人源非人灵长类动物模型中经HBB位点碱基编辑的造血干细胞的植入和长期存活功能评估
Stefan Radtke,Emily Fields,Kyle Swing et al.
Stefan Radtke et al.
Sickle cell disease (SCD) is caused by a single nucleotide change in the β-globin gene that adenine base editors can convert to the nonpathogenic Makassar β-globin variant. Here, we evaluated the long-term efficiency and off-target editin...
Atherosclerotic disease activity is associated with glycolytic enzyme expression across multiple cell types and is trackable by FDG-PET [0.03%]
动脉粥样硬化性疾病活性与多种细胞类型中的糖酵解酶表达相关，并可通过FDG-PET进行追踪
Paula Nogales,Carlos Velasco,Leticia González-Cintado et al.
Paula Nogales et al.
Positron emission tomography (PET) imaging with the radiolabeled glucose analog fluorodeoxyglucose (18FDG) is used to monitor atherosclerosis in clinical trials, but there is uncertainty regarding the plaque cell types that accumulate FDG a...
An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo [0.03%]
受ISG15缺陷启发的一种基于mRNA的广谱抗病毒药物可体内和体外抵抗病毒感染
Yemsratch T Akalu,Roosheel S Patel,Justin Taft et al.
Yemsratch T Akalu et al.
Type I interferons (IFN-Is) are cytokines with potent antiviral and inflammatory capacities. IFN-I signaling drives the expression of thousands of IFN-I-stimulated genes (ISGs), whose aggregate function results in the control of viral infec...
PIEZO1-activated donor lymphatic remodeling integrates with autologous lymphangiogenesis to enhance vein graft patency in mice [0.03%]
PIEZO1激活的供体淋巴管重塑与自体淋巴管生成整合可增强小鼠移植静脉的通畅性
Kai Chen,Rong Mou,Ziyin Guan et al.
Kai Chen et al.
The great saphenous vein is the most commonly used conduit in coronary artery bypass grafting; however, the high vein graft failure rates remain an unresolved issue. Here, we compared different harvesting techniques for mouse vein grafts an...
Proviruses in CD4+ T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia [0.03%]
CD4+T细胞中的同种抗原反应型前病毒导致HIV-1非抑制性血症
Fengting Wu,Milica Moskovljevic,Filippo Dragoni et al.
Fengting Wu et al.
Antiretroviral therapy (ART) halts human immunodeficiency virus-1 (HIV-1) replication, reducing plasma virus concentrations to below the limit of detection, but it is not curative because of a reservoir of latently infected CD4+ T cells. In...
Sequential treatment with PARPi and WEE1i enhances antitumor immune responses in preclinical models of ovarian cancer [0.03%]
PARP抑制剂和WEE1抑制剂序贯治疗在卵巢癌的临床前模型中增强抗肿瘤免疫反应
Xiaofei Jiao,Jiahao Liu,Yijie Wu et al.
Xiaofei Jiao et al.
The antitumor activity demonstrated by DNA damage response inhibitors (DDRis) can be partially attributed to their capacity to enhance immune responses. However, the toxicity of DDRis to lymphocytes, particularly when a DDRi is combined wit...
An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer [0.03%]
一种口服的血红素氧合酶抑制剂在癌症的临床前模型中靶向免疫抑制性血管周巨噬细胞
Meriem Bahri,Taha Al-Adhami,Emre Demirel et al.
Meriem Bahri et al.
A subset of perivascular tumor-associated macrophages (PvTAMs) expressing lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) relies on heme oxygenase-1 (HO-1) activity to maintain an immunologically cold tumor microenvironment, whi...
Nasal and systemic immune responses correlate with viral shedding after influenza challenge in people with complex preexisting immunity [0.03%]
复杂的既往免疫力人群在流感攻击后的鼻腔和全身免疫反应与病毒脱落相关性研究
Kathie-Anne Walters,Charles A Blatti rd,Ruoqing Zhu et al.
Kathie-Anne Walters et al.
Each year in the United States, ~50% of adults ≥18 years old are vaccinated against influenza viruses, with protective efficacy averaging 40.5% over the past 20 years. To model annual seasonal influenza, a cohort of 74 adults, who were uns...
Circulating epigenetic signatures classifying brain insulin resistance in humans [0.03%]
循环表观遗传特征可对人类脑胰岛素抵抗进行分类
Stephanie Kullmann,Amandeep Singh,Ratika Sehgal et al.
Stephanie Kullmann et al.
Brain insulin action plays an important role in metabolic and cognitive health, but there is no biomarker available to assess brain insulin resistance in humans. Here, we developed a machine learning framework based on blood DNA methylation...