Intra-amniotic antisense oligonucleotide treatment improves phenotypes in preclinical models of spinal muscular atrophy [0.03%]
宫内给予反义寡核苷酸治疗可改善脊髓性肌萎缩小鼠模型的表型
Beltran Borges,Stephen M Brown,Wan-Jin Chen et al.
Beltran Borges et al.
Neurological disorders with onset before or at birth are a leading cause of morbidity and mortality in infants and children. Prenatal treatment has the potential to reduce or prevent irreversible neuronal loss and facilitate normal neurodev...
Objective autonomic signatures of tinnitus and sound sensitivity disorders [0.03%]
耳鸣和声音过敏症的客观自主神经特征
Samuel S Smith,Kelly N Jahn,Jenna A Sugai et al.
Samuel S Smith et al.
Hypersensitivity, phantom percepts, and sensory reactivity are core features of many neurological disorders. Direct, objective measurements of these features have proven difficult to identify, leaving subjective questionnaires as the primar...
A thin cryobiopsy device compatible with transnasal endoscopy for the gastrointestinal tract [0.03%]
一种适用于胃肠内镜经鼻检查的薄型冷冻活检装置
David O Otuya,Hamid Farrokhi,Yogesh Verma et al.
David O Otuya et al.
Luminal organ biopsies are critical for disease diagnosis and are obtained using single-bite forceps inserted through the working channel of large endoscopes. Procedures using these endoscopes frequently require patient sedation or anesthes...
Somatic mosaicism in the buccal mucosa reflects lifestyle and germline risk factors for esophageal squamous cell carcinoma [0.03%]
口腔黏膜体细胞嵌合体现生活方式和食管鳞状细胞癌易感性的遗传因素关系研究
Akira Yokoyama,Koichi Watanabe,Yoshikage Inoue et al.
Akira Yokoyama et al.
Clones harboring cancer driver mutations can expand in normal tissues, known as somatic mosaicism, and can be influenced by age and environmental and germline factors. Somatic mosaicism in the blood predicts the risk of hematological malign...
Hypoglycemia promotes inner blood-retinal barrier breakdown and retinal vascular leakage in diabetic mice [0.03%]
低血糖可促进糖尿病小鼠视网膜血管渗漏及血视网膜内屏障破坏
Chuanyu Guo,Yueqi Niu,Xuemei Pan et al.
Chuanyu Guo et al.
The blood-retinal barrier (BRB) serves as a physiological boundary regulating the passage of nutrients, waste, ions, proteins, and water to and from the retina. In patients with diabetic retinopathy, breakdown of the inner BRB (iBRB) result...
Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders [0.03%]
无须预处理的脑内巨噬细胞替换改善神经退行性疾病小鼠模型表型研究
Dadian Chen,Chen Wang,Xi Chen et al.
Dadian Chen et al.
Growing genetic and pathological evidence has identified microglial dysfunction as a key contributor to the pathogenesis and progression of various neurological disorders, positioning microglia replacement as a promising therapeutic strateg...
Hypoxia-inducible factors link poor glycemic controlto diabetic retinopathy [0.03%]
低氧诱导因子将糖化血红蛋白与糖尿病视网膜病变相连
Yusuke Ichiyama,Przemyslaw Sapieha
Yusuke Ichiyama
Hypoglycemic episodes exacerbate diabetic eye disease, which is targetable by dual-HIF inhibition (Guo et al., this issue).
Inclusion of a retroviral protease enhances the immunogenicity of VLP-forming mRNA vaccines against HIV-1 or SARS-CoV-2 in mice [0.03%]
在小鼠中，包含逆转录病毒蛋白酶可增强基于mRNA的病毒样颗粒疫苗（HIV-1或SARS-CoV-2）免疫原性
Peng Zhang,Mamta Singh,Vada A Becker et al.
Peng Zhang et al.
Messenger RNA (mRNA) has emerged as a highly effective and versatile platform for vaccine delivery. We previously designed a virus-like particle (VLP)-forming env-gag mRNA vaccine against human immunodeficiency virus-1 (HIV-1) that elicited...
FcγR binding differentially contributes to protection by two human monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein [0.03%]
FcγR结合方式的不同决定了两种人源单克隆抗体通过靶向Plasmodium falciparum配子体表抗原发挥保护作用的差异性
Neville K Kisalu,Lais D Silva Pereira,Jonathan D Herman et al.
Neville K Kisalu et al.
Antibodies mediate protection against a wide range of pathogens through binding and neutralizing the pathogen or through Fc-mediated effector functions. Human monoclonal antibodies (mAbs) CIS43LS and L9LS show high-affinity binding targetin...