The IL-33 and IL-4Rα blocking antibodies itepekimab and dupilumab modulate both distinct and common inflammatory mediators in asthma [0.03%]
IL-33和IL-4Rα阻断抗体它利培玛布和杜普利尤单抗调节哮喘中不同的和共同的炎症介质
Seblewongel Asrat,Wei Keat Lim,Subhashini Srivatsan et al.
Seblewongel Asrat et al.
Biologics targeting interleukin-4 receptor subunit α (IL-4Rα) and interleukin-33 (IL-33) have demonstrated clinical efficacy in asthma, highlighting the importance of IL-4, IL-13, and IL-33 in respiratory diseases. Despite this, few studi...
Leucine-rich α-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice [0.03%]
白蛋白家族成员Leucine-rich α-2-糖蛋白1诱导糖尿病小鼠视网膜病变发生
Giulia De Rossi,Ao-Wang Qiu,Maxime Berg et al.
Giulia De Rossi et al.
Diabetic retinopathy (DR) is a common complication of diabetes mellitus and a leading cause of visual impairment and blindness in the working-age population. The early stage of the disease is characterized by retinal capillary dysfunction, ...
HIVEP1 aggravates NASH by reprogramming polyamine metabolism in TH17 cells [0.03%]
HIVEP1通过重新编程TH17细胞的多胺代谢来加重NASH
Yidan Ren,Xiaoyan Liu,Maoxiao Feng et al.
Yidan Ren et al.
Nonalcoholic steatohepatitis (NASH) is a chronic, inflammatory form of nonalcoholic fatty liver disease (NAFLD) that frequently progresses to cirrhosis and hepatocellular carcinoma (HCC). However, the role of various immune cells in switchi...
Conversion of pathogenic T cells into functionally stabilized Treg cells for antigen-specific immunosuppression in pemphigus vulgaris [0.03%]
皮质类固醇诱导的调节性T细胞抑制天疱疮中的致病T细胞
Miho Mukai,Hayato Takahashi,Yoko Kubo et al.
Miho Mukai et al.
Antigen-specific immunotherapy represents one candidate strategy for treating autoimmune diseases such as pemphigus vulgaris, a skin autoimmune disorder mediated by anti-desmoglein 3 (Dsg3) autoantibodies. We developed a therapeutic strateg...
Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases [0.03%]
生成具有功能性稳定和抗原特异性的调节性T细胞用于炎症疾病的细胞治疗
Norihisa Mikami,Ryoji Kawakami,Atsushi Sugimoto et al.
Norihisa Mikami et al.
One strategy for antigen-specific immunosuppression is to convert antigen-specific conventional T (Tconv) cells into Foxp3+ regulatory T (Treg) cells that are as stably suppressive as naturally occurring Treg (nTreg) cells. To achieve the c...
LRRC8A constitutively inhibits pain hypersensitivity in rodent models by restraining NMDA receptor activity at spinal cord synapses [0.03%]
LRRC8A通过限制脊髓突触处NMDA受体活性在啮齿类动物模型中持续抑制疼痛过敏反应
Meichun Deng,Shao-Rui Chen,Meng-Hua Zhou et al.
Meichun Deng et al.
Amplification of nociceptive transmission due to aberrant N-methyl-d-aspartate receptor (NMDAR) hyperactivity in the spinal cord is a key characteristic of neuropathic pain. However, under normal conditions, both presynaptic and postsynapti...
Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice [0.03%]
计算设计的mrna启动蛋白质纳米颗粒免疫原可诱导小鼠产生保护性抗体和t细胞反应
Grace G Hendricks,Lilit Grigoryan,Mary Jane Navarro et al.
Grace G Hendricks et al.
Messenger RNA (mRNA) vaccines and computationally designed protein nanoparticle vaccines were both clinically derisked and licensed for the first time during the coronavirus disease 2019 (COVID-19) pandemic. These vaccine modalities have co...
Low-dose glucocorticoids attenuate crescentic glomerulonephritis by inhibiting the local differentiation of proinflammatory neutrophils [0.03%]
小剂量糖皮质激素通过抑制促炎性中性粒细胞的局部分化治疗新月体性肾小球肾炎
Junping Yin,Melanie Eichler,Darius P Schaub et al.
Junping Yin et al.
Glucocorticoids are widely used to treat autoimmune diseases like crescentic glomerulonephritis (cGN), but their immunosuppressive functions are not fully understood. Here, we generated a single immune cell sequencing atlas at different sta...
Biselective remodeling of the melanoma tumor microenvironment prevents metastasis and enhances immune activation in mouse models [0.03%]
在小鼠模型中，双选择性重塑黑色素瘤肿瘤微环境可防止转移并增强免疫活化
Nikolaos A Afratis,Shivang Parikh,Idan Adir et al.
Nikolaos A Afratis et al.
The extracellular matrix (ECM) plays a crucial role in supporting metastasis in solid malignancies, yet effective ECM-targeted therapies remain scarce. Here, we introduce a dual-targeting strategy to combat melanoma by leveraging bispecific...
Deletion of the X-chromosomal gene Kdm6a in microglia of female mice ameliorates neuroinflammation and restores translatome profiles [0.03%]
小鼠小胶质细胞中删除X染色体上的Kdm6a基因可减轻神经炎症并恢复翻译组学谱型
Yuichiro Itoh,Noriko Itoh,Sophia Wendin et al.
Yuichiro Itoh et al.
Women are more susceptible to multiple sclerosis (MS) than men, with a reported incidence ratio of ~3:1. Kdm6a is an X-chromosomal gene that escapes X inactivation, leading to higher expression of the histone demethylase KDM6A in females co...