Evidence for a continuum of genetic, phenotypic, and biochemical abnormalities in children with growth hormone insensitivity [0.03%]
生长激素不敏感儿童遗传、表型和生化异常连续性的证据
Alessia David,Vivian Hwa,Louise A Metherell et al.
Alessia David et al.
GH insensitivity (GHI) presents in childhood as growth failure and in its severe form is associated with dysmorphic and metabolic abnormalities. GHI may be caused by genetic defects in the GH-IGF-I axis or by acquired states such as chronic...
Pituitary stem cell update and potential implications for treating hypopituitarism [0.03%]
垂体干细胞研究新进展及其在治疗垂体功能减退症中的潜在应用价值
Frederic Castinetti,Shannon W Davis,Thierry Brue et al.
Frederic Castinetti et al.
Stem cells have been identified in organs with both low and high cell turnover rates. They are characterized by the expression of key marker genes for undifferentiated cells, the ability to self-renew, and the ability to regenerate tissue a...
Julian C Lui,Jeffrey Baron
Julian C Lui
Recent studies have begun to provide insight into a long-standing mystery in biology-why body growth in animals is rapid in early life but then progressively slows, thus imposing a limit on adult body size. This growth deceleration in mamma...
Fu-Jung Lin,Jun Qin,Ke Tang et al.
Fu-Jung Lin et al.
Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) belong to the steroid/thyroid hormone receptor superfamily. Cloning of their cDNAs demonstrated the existence of two distinct but related genes: COUP-TFI (EAR-3, NR2F1) an...
Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure [0.03%]
转化生长因子-β超家族在调节肥胖和能量消耗中的新兴作用
Nader Zamani,Chester W Brown
Nader Zamani
Members of the TGF-β superfamily regulate many aspects of development, including adipogenesis. Studies in cells and animal models have characterized the effects of superfamily signaling on adipocyte development, adiposity, and energy expen...
Annamaria Colao,Renata S Auriemma,Gaetano Lombardi et al.
Annamaria Colao et al.
Somatostatin analogs (SA) are widely used in acromegaly, either as first-line or adjuvant treatment after surgery. First-line treatment with these drugs is generally used in the patients with macroadenomas or in those with clinical conditio...
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse [0.03%]
生长激素受体基因敲除(GHR-/-)小鼠的内分泌参数和表型特征分析
Edward O List,Lucila Sackmann-Sala,Darlene E Berryman et al.
Edward O List et al.
Disruption of the GH receptor (GHR) gene eliminates GH-induced intracellular signaling and, thus, its biological actions. Therefore, the GHR gene disrupted mouse (GHR-/-) has been and is a valuable tool for helping to define various paramet...
Developmental programming of energy balance and its hypothalamic regulation [0.03%]
能量平衡及其下丘脑调节的发育编程作用
Floor Remmers,Henriette A Delemarre-van de Waal
Floor Remmers
Developmental programming is an important physiological process that allows different phenotypes to originate from a single genotype. Through plasticity in early life, the developing organism can adopt a phenotype (within the limits of its ...
Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit [0.03%]
人类胎儿肾上腺皮质的发育和功能：胎盘单位的一个关键组成部分
Hitoshi Ishimoto,Robert B Jaffe
Hitoshi Ishimoto
Continuous efforts have been devoted to unraveling the biophysiology and development of the human fetal adrenal cortex, which is structurally and functionally unique from other species. It plays a pivotal role, mainly through steroidogenesi...
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders [0.03%]
人类类固醇生成的分子生物学、生化和生理及其紊乱
Walter L Miller,Richard J Auchus
Walter L Miller
Steroidogenesis entails processes by which cholesterol is converted to biologically active steroid hormones. Whereas most endocrine texts discuss adrenal, ovarian, testicular, placental, and other steroidogenic processes in a gland-specific...