Endometriosis-associated Pain: Mechanism, Neuroimmune Signature, and Translational Precision Strategies [0.03%]
子宫内膜异位症相关痛经的机制、神经免疫特征及转化精准治疗策略
Harriet J Omenge,Paulina A Kempa,Jae-Wook Jeong et al.
Harriet J Omenge et al.
Endometriosis affects approximately 10% of reproductive-aged women worldwide and is a leading cause of chronic pelvic pain. Despite its high prevalence and substantial socioeconomic burden, the mechanisms underlying endometriosis-associated...
Matyas Jelinek,Karolien De Bosscher,Claude Libert et al.
Matyas Jelinek et al.
Sepsis, a life-threatening syndrome caused by dysregulated host responses to infection, remains a major global health challenge with high mortality and no specific therapy. Profound disturbances in immune and metabolic homeostasis, two tigh...
Beyond aldosterone and renin: emerging biomarkers for diagnosing and subtyping primary aldosteronism [0.03%]
超越醛固酮和肾素：诊断特发性醛固酮增多症及其分型的新生物标志物
Renata Libianto,Charlotte L Uniacke,Peter J Fuller et al.
Renata Libianto et al.
Primary aldosteronism (PA) is the most common endocrine cause of high blood pressure, affecting more than 1 in 10 people with hypertension. Once considered rare, it has become a public health priority because undiagnosed PA confers signific...
Yoshi Tan,Michael J Stark,Vicki L Clifton et al.
Yoshi Tan et al.
The prepartum surge in plasma glucocorticoids is a critical signal for fetal organ maturation, facilitating the transition from fetal reliance on the placenta for functions including respiration, nutrition, and waste removal to newborn use ...
Insulin/IGF signaling in islet biology and its therapeutic implications [0.03%]
胰岛素/IGF信号在胰岛生物学及其治疗中的作用
Hyunki Kim,Rohit N Kulkarni
Hyunki Kim
The islet of Langerhans (or pancreatic islet) is a unique endocrine organ that secretes multiple hormones that in turn orchestrate energy metabolism in humans. As in other metabolic organs, growth factor(s) regulate functional islet mass to...
Epigenetics and Childhood Obesity: DNA Methylation Coordinates Environment and Gene Regulation [0.03%]
表观遗传学与儿童肥胖：DNA甲基化协调环境和基因调控
Suneesh Kaimala,Melvin Khee-Shing Leow,Suraiya Anjum Ansari et al.
Suneesh Kaimala et al.
Childhood obesity is a complex disorder which results from the combined contribution of genetics, the environment, and development, which is programmed and coordinated by epigenetic mechanisms. Of them, DNA methylation has emerged as an imp...
Regulatory Cycles of Orexin and Glucagon-Like Peptide-1 in Post-Viral Syndromes [0.03%]
与后病毒综合征相关的食欲素和GLP-1的调节周期
Jana Ruhrländer,Elisabeth Schieffer,Bernhard Schieffer
Jana Ruhrländer
Post-viral syndromes are heterogeneous multisystem diseases without a uniform etiology that occur as a result of acute viral infections. During the COVID-19 pandemic, the number of patients increased dramatically due to infections with seve...
Diverse SOX3 genetic variants and their associated phenotypic spectrum in human disease [0.03%]
人类疾病中SOX3基因组变异及其表型谱系的多样性
Chiara De Dominicis,Maria Francesca Birtolo,Andrea G Lania et al.
Chiara De Dominicis et al.
SOX3 is a single-exon gene located on the X chromosome (Xq27.1), encoding a transcription factor critical for early central nervous system and pituitary development, as well as gonadal function. A growing body of literature reports a divers...
Acromegaly and Cardiovascular Disease: Mechanisms, Clinical Impact, and Evolving Management [0.03%]
肢端肥大症和心血管疾病：机制、临床影响及治疗进展
Marta Araujo-Castro,Pedro Marques,Luis Miguel Cardoso et al.
Marta Araujo-Castro et al.
Cardiovascular disease is one of the most common and serious complications of acromegaly and a leading contributor to reduced life expectancy in affected individuals. This review examines the prevalence, mechanisms, diagnosis, and managemen...
Michelle Toth Castillo,Shauntina Drayton Powell,Amy Biermann et al.
Michelle Toth Castillo et al.
Gestational diabetes mellitus (GDM), defined as glucose intolerance that starts during pregnancy, represents a major public health challenge because it is a major cause of adverse maternal and fetal outcomes and presents a significant high ...