Safeguarding the development of offspring: the role of genetic integrity of the maternal germline [0.03%]
保障子代的正常发育——母系生殖细胞遗传完整性的作用
Xuebi Cai,Karla J Hutt,Amy L Winship et al.
Xuebi Cai et al.
Human development begins with the fusion of sperm and oocyte, yet the maternal genome plays a far more active and essential role than traditionally appreciated. This review critically examines the influence of maternal genetic integrity on ...
Yan Wang,Junxue Wang,Sijia Dan et al.
Yan Wang et al.
Immune checkpoint molecules (ICMs) are a class of surface proteins predominantly expressed on immune cells that play a key role in maintaining immune homeostasis by regulating the functions of T cells and other immune cells. Beyond their es...
Single-Cell Landscapes of Adipose-Derived Mesenchymal Stem Cells: From Homeostatic Regulators to Obesity-Driven Central Hubs [0.03%]
单细胞景观下的脂肪源间充质干细胞：从稳态调节器到肥胖驱动的中心节点
Andreas Ritter,Nina-Naomi Kreis,Frank Louwen et al.
Andreas Ritter et al.
The prevalence of obesity is steadily increasing worldwide. Obesity profoundly alters the composition, structure, and function of adipose tissue (AT), the largest endocrine organ in the body. Adipose-derived mesenchymal stem cells (ASCs) ar...
Angeliki M Angelidi,Chrysoula Boutari,Michail Kokkorakis et al.
Angeliki M Angelidi et al.
Obesity is an alarmingly growing global epidemic strongly associated with type 2 diabetes, cardiovascular disease, metabolic syndrome, and chronic kidney disease. Metabolic dysfunction-associated steatotic liver disease (MASLD) is considere...
Genetic and environmental drivers of craniofacial, brain, and pituitary disorders [0.03%]
颅面、脑和垂体疾病的遗传和环境驱动因素
Sally A Camper,Julian Martinez-Mayer,Shalini Guha et al.
Sally A Camper et al.
Congenital pituitary hormone deficiency (CH) is a rare disorder that usually involves deficient production of growth hormone (GH) and other pituitary hormones. Many cases are syndromic, affecting other aspects of craniofacial development an...
Stanniocalcin 1 at the nexus of calcium homeostasis, IGF signaling, and cancer immunity [0.03%]
钙稳态、胰岛素样生长因子信号传导和癌症免疫的交汇点——钙调蛋白1
Cunming Duan
Cunming Duan
The textbook view of the regulation of calcium homeostasis centers on parathyroid hormone, calcitriol, and calcitonin. While this paradigm has long dominated the field, it represents only part of a broader evolutionary and physiological lan...
Newer and novel antidiabetic drug classes across the cardiovascular-kidney-metabolic continuum [0.03%]
心血管-肾脏-代谢连续体上新出现的和新颖的抗糖尿病药物类别
Konstantinos Stefanakis,Paschalis Karakasis,Dimitra Vasdeki et al.
Konstantinos Stefanakis et al.
Cardiovascular-kidney-metabolic (CKM) syndrome represents an intricate and interdependent nexus among metabolic risk factors, such as diabetes and obesity, chronic kidney disease (CKD), and cardiovascular disease (CVD), collectively exertin...
Olivia Sherwin,Kaitlin J Basham,Cynthia L Andoniadou
Olivia Sherwin
Endocrine tissues must continuously adjust their structure and function in response to circadian cues, metabolic state, and physiological stress. Within these dynamic systems, stem cells contribute not only to tissue maintenance and repair ...
Sex Hormones & Exercise in the Musculoskeletal System: From Signaling to Structure and Function [0.03%]
性激素与运动对肌肉骨骼系统的影响：从信号到结构和功能
Caitlin J Colicchio,Paula A Hernandez,Jennifer L Robinson et al.
Caitlin J Colicchio et al.
Sex steroid hormones, such as estrogen, progesterone, and testosterone, are primarily known as critical regulators of reproductive function in both males and females. However, increasing evidence indicates that fluctuating levels of sex hor...
DAX-1 in sex determination and gonadal development: revisiting the anti-testis hypothesis [0.03%]
DAX-1在性别决定和性腺发育中的作用：重温抗睾丸假说
Barbara Bardoni,Enzo Lalli
Barbara Bardoni
DAX-1 (NR0B1) is a pivotal regulator of mammalian reproductive and endocrine development. Discovered as a gene whose dosage imbalance can reverse sex in XY individuals, DAX-1 is now recognized as a key component of the network controlling g...