Bramanandam Manavathi,Oindrilla Dey,Vijay Narsihma Reddy Gajulapalli et al.
Bramanandam Manavathi et al.
Estrogen or 17β-estradiol, a steroid hormone, plays a critical role in the development of mammary gland via acting through specific receptors. In particular, estrogen receptor-α (ERα) acts as a transcription factor and/or a signal transd...
Imaging of β-cell mass and insulitis in insulin-dependent (Type 1) diabetes mellitus [0.03%]
胰岛素依赖型（1型）糖尿病的β细胞质量及 insulitis 的影像学研究
Valentina Di Gialleonardo,Erik F J de Vries,Marco Di Girolamo et al.
Valentina Di Gialleonardo et al.
Insulin-dependent (type 1) diabetes mellitus is a metabolic disease with a complex multifactorial etiology and a poorly understood pathogenesis. Genetic and environmental factors cause an autoimmune reaction against pancreatic β-cells, cal...
Harpal S Randeva,Bee K Tan,Martin O Weickert et al.
Harpal S Randeva et al.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age and is associated with various metabolic perturbations, in addition to chronic anovulation and factors related to androgen excess. In g...
Lisa K Chopin,Inge Seim,Carina M Walpole et al.
Lisa K Chopin et al.
Ghrelin, the endogenous ligand for the GH secretagogue receptor (GHSR), is a peptide hormone with diverse physiological roles. Ghrelin regulates GH release, appetite and feeding, gut motility, and energy balance and also has roles in the ca...
GnRH receptors in cancer: from cell biology to novel targeted therapeutic strategies [0.03%]
促性腺激素释放激素受体在癌症中的作用：从细胞生物学至新型靶向治疗策略
Patrizia Limonta,Marina Montagnani Marelli,Stefania Mai et al.
Patrizia Limonta et al.
The crucial role of pituitary GnRH receptors (GnRH-R) in the control of reproductive functions is well established. These receptors are the target of GnRH agonists (through receptor desensitization) and antagonists (through receptor blockad...
Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors [0.03%]
阿尔茨海默病中的脂质代谢和神经炎症：肝脏X受体的作用
Jihong Kang,Serge Rivest
Jihong Kang
Liver X receptors (LXR) are nuclear receptors that have emerged as key regulators of lipid metabolism. In addition to their functions as cholesterol sensors, LXR have also been found to regulate inflammatory responses in macrophages. Alzhei...
Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system: from basic to translational research [0.03%]
促黑素细胞皮质激素原衍肽及其受体在骨关节系统中的作用：从基础到转化研究
Markus Böhm,Susanne Grässel
Markus Böhm
Proopiomelanocortin (POMC)-derived peptides such as melanocortins and β-endorphin (β-ED) exert their pleiotropic effects via binding to melanocortin receptors (MCR) and opioid receptors (OR). There is now compelling evidence for the exist...
Hua Zhu Ke,William G Richards,Xiaodong Li et al.
Hua Zhu Ke et al.
The processes of bone growth, modeling, and remodeling determine the structure, mass, and biomechanical properties of the skeleton. Dysregulated bone resorption or bone formation may lead to metabolic bone diseases. The Wnt pathway plays an...
Cardiovascular phenotype in Turner syndrome--integrating cardiology, genetics, and endocrinology [0.03%]
Turner综合征的心血管表型-整合心脏病学、遗传学和内分泌学
Kristian H Mortensen,Niels H Andersen,Claus H Gravholt
Kristian H Mortensen
Cardiovascular disease is emerging as a cardinal trait of Turner syndrome, being responsible for half of the 3-fold excess mortality. Turner syndrome has been proposed as an independent risk marker for cardiovascular disease that manifests ...
The nonskeletal effects of vitamin D: an Endocrine Society scientific statement [0.03%]
维生素D的非骨骼效应：内分泌学会科学声明
Clifford J Rosen,John S Adams,Daniel D Bikle et al.
Clifford J Rosen et al.
Significant controversy has emerged over the last decade concerning the effects of vitamin D on skeletal and nonskeletal tissues. The demonstration that the vitamin D receptor is expressed in virtually all cells of the body and the growing ...