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Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system: from basic to translational research

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Proopiomelanocortin (POMC)-derived peptides such as melanocortins and β-endorphin (β-ED) exert their pleiotropic effects via binding to melanocortin receptors (MCR) and opioid receptors (OR). There is now compelling evidence for the existence of a functional... ...