Growth Hormone Action as a Target in Cancer: Significance, Mechanisms and Possible Therapies [0.03%]
生长激素在癌症治疗中的作用：意义、机制和可能的治疗方法
Reetobrata Basu,Cesar L Boguszewski,John J Kopchick
Reetobrata Basu
Growth hormone (GH) is a pituitary derived endocrine hormone required for normal post-natal growth and development. Hypo or hypersecretion of endocrine GH results in two pathologic conditions, namely GH deficiency (GHD) and acromegaly. Addi...
Exogenous Opioids and the Human Endocrine System: An Endocrine Society Scientific Statement [0.03%]
外源性阿片类与人类内分泌系统：内分泌协会科学声明
Niki Karavitaki,Jeffrey J Bettinger,Nienke Biermasz et al.
Niki Karavitaki et al.
The use and misuse of opioids are a growing global problem. Although the effects of these drugs on the human endocrine system have been studied for decades, attention on their related clinical consequences, particularly on the hypothalamic-...
Cheryl A Conover,Claus Oxvig
Cheryl A Conover
There is strong evidence that insulin-like growth factor (IGF) signaling is involved in fundamental aspects of the aging process. However, the extracellular part of the IGF system is complex with various receptors, ligand effectors, high af...
Ruth Prieto,Tareq A Juratli,Evan D Bander et al.
Ruth Prieto et al.
Papillary craniopharyngioma (PCP) is a rare type of tumor, comprising ∼20% of all craniopharyngioma (CP) cases. It is now recognized as a separate pathological entity from the adamantinomatous type. PCPs are benign tumors, classified as WH...
Robert Krysiak,Hedi L Claahsen-van der Grinten,Nicole Reisch et al.
Robert Krysiak et al.
Treatment of classic congenital adrenal hyperplasia (CAH) is directed at replacing deficient hormones and reducing androgen excess. However, even in the era of early diagnosis and lifelong hormonal substitution, the presence of CAH is still...
Postbiotic impact on host metabolism and immunity provides therapeutic potential in metabolic disease [0.03%]
后生元对宿主代谢和免疫的影响及其在代谢性疾病治疗中的潜力
Han Fang,Rodrigo Rodrigues E-Lacerda,Nicole G Barra et al.
Han Fang et al.
The gut microbiota influences aspects of metabolic disease, including tissue inflammation, adiposity, blood glucose, insulin, and endocrine control of metabolism. Prebiotics or probiotics are often sought to combat metabolic disease. Howeve...
Tobias Stalder,Henrik Oster,James L Abelson et al.
Tobias Stalder et al.
In healthy individuals, the majority of cortisol secretion occurs within several hours surrounding morning awakening. A highly studied component of this secretory period is the cortisol awakening response (CAR), the rapid increase in cortis...
Structure and Function of Somatostatin and its Receptors in Endocrinology [0.03%]
生长抑素及其受体在内分泌学中的结构与功能
Bo Zhang,Li Xue,Zhe Bao Wu
Bo Zhang
Somatostatin analogs, such as octreotide (OCT), lanreotide, and pasireotide, which function as somatostatin receptor ligands (SRLs), are the main drugs used for the treatment of acromegaly. These ligands are also used as important molecules...
Ioanna Gianopoulos,Christos S Mantzoros,Stella S Daskalopoulou
Ioanna Gianopoulos
Adiponectin is an abundantly secreted hormone that communicates information between the adipose tissue, and the immune and cardiovascular systems. In metabolically healthy individuals, adiponectin is usually found at high levels and helps i...
Molecular Developments in Parasellar Tumors and Potential Therapeutic Implications [0.03%]
鞍区肿瘤的分子进展及其潜在治疗意义
Paraskevi Xekouki,Vasiliki Venetsanaki,Georgios Kyriakopoulos et al.
Paraskevi Xekouki et al.
The parasellar region is the anatomical area around the sella turcica that represents a crucial crossroad for important adjacent structures. Several distinct tumors can primarily originate from this area, the most common being meningiomas, ...