Neuronal KGB-1 JNK MAPK signaling regulates the dauer developmental decision in response to environmental stress in Caenorhabditis elegans [0.03%]
神经元中的KGB-1 JNK MAPK信号通过响应环境压力调控秀丽隐杆线虫的发育决定 dauers发育决定过程
Deepshikha Dogra,Warakorn Kulalert,Frank C Schroeder et al.
Deepshikha Dogra et al.
In response to stressful growth conditions of high population density, food scarcity, and elevated temperature, young larvae of nematode Caenorhabditis elegans can enter a developmentally arrested stage called dauer that is characterized by...
Unraveling the Gordian knot: genetics and the troubled road to effective therapeutics for Alzheimer's disease [0.03%]
解开戈迪安结：阿尔茨海默病的有效治疗之路的遗传学研究与挑战
Linda L Restifo
Linda L Restifo
In the late 20th century, identification of the major protein components of amyloid plaques and neurofibrillary tangles provided a window into the molecular pathology of Alzheimer's disease, ushering in an era of optimism that targeted ther...
A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary [0.03%]
研究果蝇卵巢转座子控制的遗传工具箱
Mostafa F ElMaghraby,Laszlo Tirian,Kirsten-André Senti et al.
Mostafa F ElMaghraby et al.
Argonaute proteins of the PIWI clade complexed with PIWI-interacting RNAs (piRNAs) protect the animal germline genome by silencing transposable elements. One of the leading experimental systems for studying piRNA biology is the Drosophila m...
Dynamic sampling bias and overdispersion induced by skewed offspring distributions [0.03%]
由偏态后代分布引起的动态抽样偏差和过离散现象
Takashi Okada,Oskar Hallatschek
Takashi Okada
Natural populations often show enhanced genetic drift consistent with a strong skew in their offspring number distribution. The skew arises because the variability of family sizes is either inherently strong or amplified by population expan...
Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin [0.03%]
人类病原体烟曲霉对抗真菌药卡泊芬净的转录反应异质性
Ana Cristina Colabardini,Fang Wang,Zhiqiang Dong et al.
Ana Cristina Colabardini et al.
Aspergillus fumigatus is the main causative agent of invasive pulmonary aspergillosis (IPA), a severe disease that affects immunosuppressed patients worldwide. The fungistatic drug caspofungin (CSP) is the second line of therapy against IPA...
The correlation of substitution effects across populations and generations in the presence of nonadditive functional gene action [0.03%]
在基因功能非加性作用存在的情况下，不同种群和世代替代效应的相关性
Andres Legarra,Carolina A Garcia-Baccino,Yvonne C J Wientjes et al.
Andres Legarra et al.
Allele substitution effects at quantitative trait loci (QTL) are part of the basis of quantitative genetics theory and applications such as association analysis and genomic prediction. In the presence of nonadditive functional gene action, ...
Isoform-specific roles of the Drosophila filamin-type protein Jitterbug (Jbug) during development [0.03%]
果蝇filamin型蛋白Jitterbug(Jbug)的异构体在发育过程中的特异性作用
SeYeon Chung,Thao Phuong Le,Vishakha Vishwakarma et al.
SeYeon Chung et al.
Filamins are highly conserved actin-crosslinking proteins that regulate organization of the actin cytoskeleton. As key components of versatile signaling scaffolds, filamins are implicated in developmental anomalies and cancer. Multiple isof...
Quantitative trait loci controlling agronomic and biochemical traits in Cannabis sativa [0.03%]
大麻（Cannabis sativa）农艺和生化性状的定量性状位点分析
Patrick Woods,Brian J Campbell,Timothy J Nicodemus et al.
Patrick Woods et al.
Understanding the genetic basis of complex traits is a fundamental goal of evolutionary genetics. Yet, the genetics controlling complex traits in many important species such as hemp (Cannabis sativa) remain poorly investigated. Because hemp...
Erratum to: The genetic architecture of human complex phenotypes is modulated by linkage disequilibrium and heterozygosity [0.03%]
遗传多态性影响基因型-表型关系的遗传结构的证据修正版：人类复杂表型的遗传构成受到链锁不平衡和杂合性的影响
Dominic Holland,Oleksandr Frei,Rahul Desikan et al.
Dominic Holland et al.
Published Erratum
Genetics. 2021 Jun 24;218(2):iyab064. DOI:10.1093/genetics/iyab064 2021
Methods for analyzing neuronal structure and activity in Caenorhabditis elegans [0.03%]
用于分析秀丽隐杆线虫神经元结构和活动的方法
Scott W Emmons,Eviatar Yemini,Manuel Zimmer
Scott W Emmons
The model research animal Caenorhabditis elegans has unique properties making it particularly advantageous for studies of the nervous system. The nervous system is composed of a stereotyped complement of neurons connected in a consistent ma...