A species-specific nuclear receptor was integrated into a developmental polyphenism pathway [0.03%]
一种物种特异性的核受体整合进了发育多分型途径中
Eleni Katsougia,Samantha J Connors,Erik J Ragsdale
Eleni Katsougia
Polyphenism, the ability of an organism to develop discrete, alternative forms of a trait in response to environmental signals, relies on molecular switches to guide developmental trajectories. In the nematode Pristionchus pacificus, such a...
PhaseGen: Exact Solutions for Time-Inhomogeneous Multivariate Coalescent Distributions under Diverse Demographies [0.03%]
PhaseGen：多元非均匀合并分布的精确解及其在各种人口遗传学中的应用
Janek Sendrowski,Asger Hobolth
Janek Sendrowski
Phase-type theory is emerging as a powerful framework for modeling coalescent processes, allowing for the exact computation of quantities of interest. This includes moments of tree height, total branch length, the site-frequency spectrum (S...
Quantile-specific confounding: correction for subtle population stratification via quantile regression [0.03%]
分位数特异性混杂因素：通过分位数回归校正细微的群体分层问题
Chen Wang,Marco Masala,Edoardo Fiorillo et al.
Chen Wang et al.
Subtle population structure remains a significant concern in genome-wide association studies. Using human height as an example, we show how quantile regression, a natural extension of linear regression, can better correct for subtle populat...
Global epistasis in budding yeast driven by many natural variants whose effects scale with fitness [0.03%]
受众多自然变异影响的芽殖酵母全局性上位效应及其与适应性的关系
Ilan Goldstein,Joseph J Hale,Ian M Ehrenreich
Ilan Goldstein
Global epistasis is a phenomenon in which the effects of genetic perturbations depend on the fitness of the individuals in which they occur. In populations with natural genetic variation, global epistasis arises from interactions between pe...
Translation regulation promotes stress adaptation in the human fungal pathogen Candida glabrata [0.03%]
翻译调控促进人形念珠菌应激适应
Aishwarya Rana,Anil Thakur
Aishwarya Rana
Invasive candidiasis presents a significant healthcare challenge. The Human opportunistic fungal pathogen Candida glabrata, a cause of mucosal and deep-seated infections, resists key antifungal drugs and rapidly proliferates within host mac...
Effects of inbreeding on balancing selection: Insights from Fisher's geometric model [0.03%]
近亲繁殖对平衡选择的影响——来自费希尔几何模型的启示
Colin Olito,Tim Connallon
Colin Olito
Balancing selection is a potentially important factor in the maintenance of genetic variation for fitness and, alongside recessive deleterious mutations, the genetic basis of inbreeding depression. Classic population genetics theory predict...
Vasilisa Sidarava,Sarah Mearns,David Lydall
Vasilisa Sidarava
The ends of linear eukaryotic chromosomes are protected from being recognized as DNA double-strand breaks by telomeres, containing repetitive DNA sequences which bind specific proteins. In humans, mutations in telomere regulatory genes lead...
Excretory gland cell and NSPC genes in C. elegans: Investigating their physiological roles [0.03%]
线虫排泄细胞和神经干细胞基因的生理功能研究
Zuzanna Mackiewicz,Vladyslava Liudkovska,Andrzej Dziembowski
Zuzanna Mackiewicz
The nematode Caenorhabditis elegans is one of the best-studied model organisms in molecular biology; however, many aspects of its physiology and the functions of many genes remain poorly understood. In this study, we investigated the role o...
The genetic architecture of quantitative variation in the self-incompatibility response within Phlox drummondii (Polemoniaceae) [0.03%]
报春花科 Drummond 飞燕草(PHOX DRUMMONDII) 自交不亲和反应的数量变异的遗传构成
Grace A Burgin,Federico Roda,Matthew Farnitano et al.
Grace A Burgin et al.
Flowering plants display extensive variation in selfing rate, a trait with significant ecological and evolutionary consequences. Many species use genetic mechanisms to recognize and reject self-pollen (termed self-incompatibility or SI), an...
Analysis of a BCOR internal tandem duplication in mouse embryonic stem cell to neuronal precursor differentiation [0.03%]
分析BCOR内含子串联重复小鼠胚胎干细胞向神经前体细胞分化中的作用
Zuzer Dhoondia,Hyuckjoon Kang,Kwangwoon Lee et al.
Zuzer Dhoondia et al.
BCOR (BCL-6 corepressor) is a component of variant Polycomb Repressive Complex 1.1 (vPRC1.1), one of several vPRC1 complexes that catalyze histone H2A ubiquitination thought to play an important role in PRC2 binding and the deposition of H3...