Efficient epistasis inference via higher-order covariance matrix factorization [0.03%]
高效通过高阶协方差矩阵分解进行上位性推理
Kai S Shimagaki,John P Barton
Kai S Shimagaki
Epistasis can profoundly influence evolutionary dynamics. Temporal genetic data, consisting of sequences sampled repeatedly from a population over time, provides a unique resource to understand how epistasis shapes evolution. However, detec...
Sharri S Cyrus,Sònia Medina Giró,Tianshun Lian et al.
Sharri S Cyrus et al.
The Polycomb Repressive Complex 2 is an epigenetic reader/writer that methylates histone H3K27. Rare germline partial loss of function (pLoF) variants in core members of the complex (EZH2, EED, SUZ12) cause overgrowth and intellectual disab...
Combining ability of banana triploid hybrid progenitors and genomic prediction of cross performance for agro-morphological traits [0.03%]
三倍体香蕉亲本杂种优势及其农艺性状组合预测能力评估研究
Lucile Toniutti,Simon Rio,Camille Madec et al.
Lucile Toniutti et al.
Breeding disease-resistant cultivars that meet commercial criteria is essential to sustain banana production threatened by major diseases. Edible bananas are seedless triploid hybrids which represent end-breeding products. Hence, the crucia...
Trans-regulatory loci shape natural variation of gene expression plasticity in Arabidopsis [0.03%]
跨越调节位点影响拟南芥基因表达可塑性的自然变异
Mariele Lensink,Grey Monroe,Dan Kliebenstein
Mariele Lensink
Organisms regulate gene expression in response to environmental cues, a process known as plasticity, to adjust to changing environments. Research into natural variation and the evolution of plasticity frequently studies cis-regulatory eleme...
Augustin Clessin,Julien Joseph,Nicolas Lartillot
Augustin Clessin
GC-biased gene conversion (gBGC) is a recombination-associated evolutionary process that biases the segregation ratio of AT:GC polymorphisms in the gametes of heterozygotes, in favour of GC alleles. This process is the major determinant of ...
Antoine Aragon,Amaury Lambert,Thierry Mora et al.
Antoine Aragon et al.
Cellular diversification in processes from development to cancer progression and affinity maturation is often linked to the appearance of new mutations, generating genetic heterogeneity. Describing the underlying coupled genetic and growth ...
Towards more sustainable research: reducing the environmental impact when working with Drosophila [0.03%]
迈向更可持续的研究：在使用果蝇进行研究时减少对环境的影响
Milo Challiner,Saroj Saurya,Sanjai Patel et al.
Milo Challiner et al.
The ever-increasing amounts of plastic waste and greenhouse gas emissions worldwide threaten our environment. Biomedical laboratories across the world generate serious amounts of plastic waste often disposed of via high-emission strategies....
Adaptive gene expression parallelism in the male reproductive tract of two Drosophila species [0.03%]
两种果蝇物种适应性基因表达平行性的雄性生殖道研究
Tiezheng Fan,Julie M Cridland,David J Begun
Tiezheng Fan
While stabilizing selection is likely an important process leading to conserved phylogenetic patterns of gene expression, the role of selection in driving expression divergence amongst populations and species is much less clear. One approac...
Analysis of Combinatorial Cohesin Subunit Gene Deletions in Budding Yeast [0.03%]
酵母菌中组合型染色体凝聚素亚基基因缺失的分析研究
Grace Duke,Robert V Skibbens
Grace Duke
Throughout the cell cycle, DNA molecules convert between hierarchical intramolecular (cis) and intermolecular (trans) associations. Cohesin ATPase complexes produce both types of DNA associations which collectively are required for sister c...
The regulatory architecture of gene expression variation in C. elegans revealed by multi-strain allele-specific analysis [0.03%]
多株系allel特异性分析揭示的秀丽隐杆线虫基因表达变异的调控架构
Avery Davis Bell,Francisco Valencia,Annalise B Paaby
Avery Davis Bell
An outstanding question in the evolution of gene expression is the composition of the underlying regulatory architecture and the processes that shape it. Mutations affecting a gene's expression may reside locally in cis or distally in trans...