Gertjan Bisschop,Konrad Lohse,Derek Setter
Gertjan Bisschop
Current methods of identifying positively selected regions in the genome are limited in two key ways: the underlying models cannot account for the timing of adaptive events and the comparison between models of selective sweeps and sequence ...
Chaozhi Zheng,Rodrigo R Amadeu,Patricio R Munoz et al.
Chaozhi Zheng et al.
In diploid species, many multiparental populations have been developed to increase genetic diversity and quantitative trait loci (QTL) mapping resolution. In these populations, haplotype reconstruction has been used as a standard practice t...
Genetic analysis argues for a coactivator function for the Saccharomyces cerevisiae Tup1 corepressor [0.03%]
遗传分析支持酿酒酵母Tup1共抑制物的共激活功能
Emily J Parnell,Timothy J Parnell,David J Stillman
Emily J Parnell
The Tup1-Cyc8 corepressor complex of Saccharomyces cerevisiae is recruited to promoters by DNA-binding proteins to repress transcription of genes, including the a-specific mating-type genes. We report here a tup1(S649F) mutant that displays...
Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1 [0.03%]
肌肉盲剪接因子的丢失通过降低p38MAPK/PMK-1和转录因子ATF-7与Nrf/SKN-1的活性来缩短秀丽隐杆线虫的寿命
Olli Matilainen,Ana R S Ribeiro,Jens Verbeeren et al.
Olli Matilainen et al.
Muscleblind-like splicing regulators (MBNLs) are RNA-binding factors that have an important role in developmental processes. Dysfunction of these factors is a key contributor of different neuromuscular degenerative disorders, including Myot...
Precise measurement of the fitness effects of spontaneous mutations by droplet digital PCR in Burkholderia cenocepacia [0.03%]
通过液滴数字PCR精确测量Burkholderia cenocepacia中自发突变的健康效应
Anita Rana,David Patton,Nathan T Turner et al.
Anita Rana et al.
Understanding how mutations affect survivability is a key component to knowing how organisms and complex traits evolve. However, most mutations have a minor effect on fitness and these effects are difficult to resolve using traditional mole...
Transposable element profiles reveal cell line identity and loss of heterozygosity in Drosophila cell culture [0.03%]
可转换元件概况揭示了果蝇细胞培养中的细胞系身份和杂合性丢失
Shunhua Han,Preston J Basting,Guilherme B Dias et al.
Shunhua Han et al.
Cell culture systems allow key insights into biological mechanisms yet suffer from irreproducible outcomes in part because of cross-contamination or mislabeling of cell lines. Cell line misidentification can be mitigated by the use of genot...
Regulation of Msh4-Msh5 association with meiotic chromosomes in budding yeast [0.03%]
出芽酵母中Msh4-Msh5与减数分裂染色体相互作用的调控机制
Krishnaprasad G Nandanan,Sagar Salim,Ajith V Pankajam et al.
Krishnaprasad G Nandanan et al.
In the baker's yeast Saccharomyces cerevisiae, most of the meiotic crossovers are generated through a pathway involving the highly conserved mismatch repair related Msh4-Msh5 complex. To understand the role of Msh4-Msh5 in meiotic crossing ...
Functional characterization of the developmental genes asm2, asm3, and spt3 required for fruiting body formation in the filamentous ascomycete Sordaria macrospora [0.03%]
发育基因asm2、asm3和spt3的功能特性分析，这些基因是丝状子囊菌Sordaria macrospora形成果实体所需的关键基因
Ramona Lütkenhaus,Jan Breuer,Minou Nowrousian
Ramona Lütkenhaus
The formation of fruiting bodies is one of the most complex developmental processes in filamentous ascomycetes. It requires the development of sexual structures that give rise to meiosporangia (asci) and meiotic spores (ascospores) as well ...
A role for the Erk MAPK pathway in modulating SAX-7/L1CAM-dependent locomotion in Caenorhabditis elegans [0.03%]
在Caenorhabditis elegans中Erk MAPK通路在调节SAX-7/L1CAM依赖型运动中的作用
Melinda Moseley-Alldredge,Seema Sheoran,Hayoung Yoo et al.
Melinda Moseley-Alldredge et al.
L1CAMs are immunoglobulin cell adhesion molecules that function in nervous system development and function. Besides being associated with autism and schizophrenia spectrum disorders, impaired L1CAM function also underlies the X-linked L1 sy...
Single-nucleus transcriptomes reveal evolutionary and functional properties of cell types in the Drosophila accessory gland [0.03%]
单核转录本揭示了果蝇副腺中细胞类型的进化和功能特性
Alex C Majane,Julie M Cridland,David J Begun
Alex C Majane
Many traits responsible for male reproduction evolve quickly, including gene expression phenotypes in germline and somatic male reproductive tissues. Rapid male evolution in polyandrous species is thought to be driven by competition among m...